Risk assessment for human metal exposures : mode of action and kinetic approaches /

Risk assessment for human metal exposures : mode of action and kinetic approaches /

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Bibliographic Details
Author / Creator:Nordberg, Gunnar, author.
Imprint:London : Academic Press, 2018.
Description:1 online resource
Language:English
Subject:
Metals -- Toxicology.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11690398
Hidden Bibliographic Details
Other authors / contributors:Fowler, Bruce A., author.
ISBN:9780128042687
0128042680
9780128042274
0128042273
Notes:Online resource; title from PDF title page (EBSCO, viewed August 24, 2018)
Summary:Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA -TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication-the classic risk assessment paradigm-with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.
Other form:Original 9780128042274 0128042273
Table of Contents:
  • Front Cover; RISK ASSESSMENT FOR HUMAN METAL EXPOSURES; RISK ASSESSMENT FOR HUMAN METAL EXPOSURES: Mode of Action and Kinetic Approaches; Copyright; DEDICATION; CONTENTS; AUTHOR BIOGRAPHIES; PREFACE; One
  • Metal Exposures and Human Health-Historical Development, Current Importance, and Toxicological Concepts for P ...; 1.1 INTRODUCTION; 1.2 WIDESPREAD EXPOSURE TO METALS CONTRIBUTES TO GLOBAL BURDEN OF DISEASE; 1.3 METAL POISONING-CLINICAL SYMPTOMS AND SIGNS IN OCCUPATIONAL AND ENVIRONMENTAL SETTINGS
  • 1.4 DETAILED INVESTIGATION IS REQUIRED FOR IDENTIFICATION OF ADVERSE EFFECTS AT LOW-LEVEL METAL EXPOSURES1.5 PERSPECTIVES ON HISTORICAL DEVELOPMENT OF CONCEPTS USED IN RISK ASSESSMENT OF METAL EXPOSURES-ROLE OF THE SCIENTIFIC COMMIT ...; 1.6 CURRENT LONG-TERM LOW-LEVEL EXPOSURES AND RELATED HEALTH EFFECTS; 1.6.1 Neurotoxicology of Metals; 1.6.2 Cardiovascular Disease Related to Metals; 1.6.3 Kidney Effects of Exposure to Metals; 1.6.4 Cancer Induced by Metal Exposures; 1.6.5 Reproductive and Developmental Effects of Metal Exposures
  • 1.7 ISSUES OF CURRENT CONCERN FOR HAZARD ASSESSMENT, RISK ASSESSMENT, AND PREVENTION1.7.1 Expanding Global Industrial Use of Metals; 1.7.2 Toxicity of Metallic Nanoparticles; 1.7.3 Environmental Mobilization Processes; 1.7.4 Toxic Metals in Food and Oral Intake; Other Intake Routes; 1.7.5 Metal Exposure by Release From Implanted Medical Devices; 1.7.6 Toxicokinetics and Dosimetry; 1.7.7 Essential Metals: Deficiency and Toxicity; 1.7.8 Biological Monitoring; 1.7.9 Interactions Among Metals and Gene-Environment Interactions
  • 1.7.10 Application of MOA TKTD Models, AOPs, or Other Systems Toxicology Approaches to Risk and Hazard Assessment of Metal Exposures1.7.11 Applied Hazard- and Risk Assessment-Preventive Action and Management; REFERENCES; Two
  • Exposure, Internal Dose, and Toxicokinetics (TK); 2.1 INTRODUCTION; TERMINOLOGY; 2.2 EXPOSURE; 2.2.1 General Considerations; 2.2.2 Exposure Through Food and Drinking Water; 2.2.3 Exposure by Inhalation; 2.3 DEPOSITION AND ABSORPTION; 2.3.1 General Considerations Including an Introduction to Skin Deposition; 2.3.2 Deposition and Absorption After Ingestion
  • 2.3.3 Deposition and Absorption After Inhalation2.3.3.1 Deposition and Absorption of Gases and Vapors; 2.3.3.2 Deposition of Particles; 2.3.3.3 Clearance of Particles From the Respiratory System; 2.3.3.3.1 Tracheobronchial Clearance; 2.3.3.3.2 Peripheral Lung Clearance and Translocation From the Respiratory Tract; 2.3.4 Total Absorption; 2.4 TRANSPORT, BIOTRANSFORMATION, AND DISTRIBUTION; 2.5 EXCRETION; 2.5.1 Gastrointestinal Excretion; 2.5.2 Excretion Through the Kidneys; 2.5.3 Excretion Rate: Biological Half-Life (Half-Time); 2.6 TOXICOKINETIC MODELS; 2.6.1 One-Compartment Model

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