Diffuse gastric cancer /

Diffuse gastric cancer /

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Bibliographic Details
Imprint:Cham, Switzerland : Springer, 2018.
Description:1 online resource
Language:English
Subject:
Stomach -- Cancer.
Stomach -- Cancer.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11705960
Hidden Bibliographic Details
Other authors / contributors:Castria, Tiago Biachi de, editor.
Guindalini, Rogo Santa Cruz, editor.
ISBN:9783319952345
331995234X
9783319952352
3319952358
9783319952338
3319952331
Digital file characteristics:text file PDF
Notes:Includes index.
Online resource; title from PDF title page (SpringerLink, viewed September 18, 2018).
Summary:We live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible. Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.
Other form:Print version: Diffuse gastric cancer. Cham, Switzerland : Springer, 2018 3319952331 9783319952338
Standard no.:10.1007/978-3-319-95234-5
Table of Contents:
  • Intro; Acknowledgments; Contents; Contributors; Chapter 1: Introduction; References; Chapter 2: Epidemiology; Incidence andMortality; Diffuse-Type Gastric Carcinoma; Risk Factors; Environmental Factors; Helicobacter pylori; Smoking; Dietary Habits andNitroso Compounds; Obesity; Epstein-Barr Virus; Host Factors; Blood Group; CDH1 Gene; Differences Between Intestinal andDiffuse Subtypes; Age ofOccurrence; Location ofTumors; H. pylori Infection; Stomach Microbiome; Interfering withtheDiffuse-Type Gastric Cancer Burden; References; Chapter 3: The Role ofEndoscopy; Preneoplastic Changes
  • DiagnosisEndoscopic Classifications; Biopsy; Endoscopic Ultrasonography Staging; Treatment; Early Gastric Cancer; Advanced Gastric Cancer; Hereditary Screening; References; Chapter 4: Pathology andMolecular Biology; Molecular Biology ofGastric Cancer; Genomic Alterations; Epigenetics; DNA Methylation; Histone Alterations; MicroRNA; Gene andProtein Expression; Pathways; E-Cadherin andCell Adhesion; E-Cadherin andtheWnt/Beta-Catenin Signaling Pathway; E-Cadherin andEpithelial-to-Mesenchymal Transition; E-Cadherin Expression andFunction; Germline andSomatic Mutations inCDH1 Gene
  • Transcriptional Regulation ofE-Cadherin ExpressionPosttranslational Regulation ofE-Cadherin Expression; RHOA Pathway; Survival According toMolecular Subtypes; References; Chapter 5: Genetic Predisposition andHereditary Syndromes; Introduction; Genetic Counseling andMutation Analysis; Screening andSurveillance; Endoscopic Screening forGastric Cancer; Breast Cancer Surveillance; Gastrectomy andMastectomy; Prophylactic Gastrectomy: Indications forandTiming ofSurgery; Prophylactic Mastectomy; References; Chapter 6: The Role ofSurgery; Management of Primary Tumor Site; Lymphadenectomy
  • Surgical AccessLaparoscopy; Prophylactic Gastrectomy inHereditary Diffuse Gastric Cancer; Diffuse Gastric Cancer inYoung Patients; Diffuse Gastric Cancer andPrognosis; Conclusions; References; Chapter 7: The Role ofRadiation Therapy; INT 0116; ARTIST Trial; SEER Data; Meta-analysis; Patterns ofRelapse; Ongoing Trials; Radiation Therapy Recommendations; References; Chapter 8: The Role ofChemotherapy; Introduction; Curative Chemotherapy forDiffuse Gastric Cancer; Clinical Trials ofCurative Chemotherapy andDiffuse Gastric Cancer; Palliative Chemotherapy forDiffuse Gastric Cancer
  • Retrospective AnalysesRandomized Clinical Trials; Second-Line Systemic Treatment; Target Therapy; Chemotherapy andMolecular Profile ofDiffuse Gastric Cancer; Imunotherapy; Conclusion; References; Index

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