Development of antibody-based therapeutics : translational considerations & challenges /

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Bibliographic Details
Edition:	Second edition.
Imprint:	Singapore : Adis, [2018]
Description:	1 online resource
Language:	English
Subject:	Monoclonal antibodies -- Therapeutic use. Antibodies, Monoclonal -- pharmacology. Antibodies, Monoclonal -- therapeutic use. Antigens -- immunology. Drug Discovery. Translational Medical Research. Monoclonal antibodies -- Therapeutic use.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11706035

Hidden Bibliographic Details
Other authors / contributors:	Tabrizi, Mohammad A., editor. Bornstein, Gadi G., editor. Klakamp, Scott L., editor.
ISBN:	9789811304965 9811304963 9789811304958 9811304955
Notes:	Includes bibliographical references. Online resource; title from PDF title page (EBSCO, viewed September 20, 2018).
Summary:	This book examines vital considerations in designing effective translational strategies in the development of antibody-based therapeutics, including the relationship between the 'unit dose' and 'unit effect' with respect to beneficial and deleterious effects.
Other form:	Print version: Development of antibody-based therapeutics. Second edition. Singapore : Adis, [2018] 9811304955 9789811304958

Table of Contents:

Introduction
Translational considerations and challenges : an overview
Considerations for construct and affinity design goals
Epitope characterization and isotype selection
Biophysical considerations for development of antibody-based therapeutics
Novel technologies for generation of bispecific constructs
Stimulus-response mechanisms : an overview
Evaluation of tumor growth inhibition in preclinical tumor models : a quantitative approach
Application of proof-of-mechanism biomarkers (POM) in design and development of biologics modalities
Antibody drug conjugates : translational considerations
Application of PK-PD modeling and simulation approaches for immuno-oncology drugs
Translational biomarkers : application in the clinical development of combination therapies
Correction to : considerations for construct and affinity design goals.

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