HIV-1 latency /
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| Imprint: | Cham, Switzerland : Springer, [2018] |
|---|---|
| Description: | 1 online resource |
| Language: | English |
| Series: | Current topics in microbiology and immunology, 0070-217X ; volume 417 Current topics in microbiology and immunology ; 417. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11718264 |
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| 245 | 0 | 0 | |a HIV-1 latency / |c Guido Silvestri, Mathias Lichterfeld, editors. |
| 264 | 1 | |a Cham, Switzerland : |b Springer, |c [2018] | |
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| 490 | 1 | |a Current topics in microbiology and immunology, |x 0070-217X ; |v volume 417 | |
| 588 | 0 | |a Online resource; title from PDF title page (SpringerLink, viewed October 18, 2018). | |
| 505 | 0 | |a Intro; Preface; Contents; 74 Molecular Control of HIV and SIV Latency; Abstract; 1 Introduction; 2 The HIV-1 and SIVmac Promoters; 3 Regulation of HIV-1/SIV Transcription; 3.1 Nuclear Topography; 3.2 Viral Integration Site; 3.3 Epigenetic Modifications of HIV-1/SIV Promoter; 3.4 Regulation of HIV-1 Transcription by Tat/P-TEFb; 3.5 The Role of Cellular Transcription Factors; 4 Post-transcriptional Regulation of HIV-1 Expression; 4.1 HIV-1 mRNA Processing and Latency; 4.2 Noncoding mRNAs and HIV-1 Latency; 5 Concluding Remarks; References | |
| 505 | 8 | |a 75 Assays to Measure Latency, Reservoirs, and ReactivationAbstract; 1 Introduction; 2 Definitions; 3 The Viral Outgrowth Assay; 3.1 Assay Design and Rationale; 3.2 Recent Improvements and Potential Problems with the QVOA; 4 The Proviral Landscape: Defective and Non-induced Proviruses; 5 Other Reservoir Assays; 5.1 PCR and Hybridization-Based Assays; 5.2 Induction Assays; 6 Other Approaches to Reservoir Measurement; 6.1 Residual Viremia; 6.2 Biomarkers; 6.3 Time to Rebound; 7 Conclusions; Acknowledgements; References; 72 The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir | |
| 505 | 8 | |a Abstract1 Introduction; 2 Innate Immune Response; 2.1 Type I Interferon and Restriction Factors; 2.2 Natural Killer Cells; 3 Adaptive Immune Response: Humoral Immunity; 3.1 HIV-1-Specific Antibodies; 3.2 The Development of Broadly Neutralizing Abs; 3.3 Abs as a Preventative or Therapeutic Treatment; 3.4 Bispecific Abs; 4 Adaptive Immune Response: Cellular Immunity; 4.1 HIV-1-Specific CD8+T Cells; 4.2 CD8+T Cell Responses in Patients with Natural Control of HIV-1 Infection; 4.3 CD8+T Cell Based Vaccines; 4.4 CD8+T Cell Based "Shock and Kill" Therapy; 5 Conclusions; References | |
| 505 | 8 | |a 73 Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral TherapyAbstract; 1 Introduction; 2 NHP/AIDS Models; 2.1 HIV-1 Infection of Nonhuman Primates; 2.2 Discovery of Simian Immunodeficiency Virus (SIV) and Simian AIDS; 2.3 SIV Infection in Different NHP Species; 3 Advantages of NHP Models for HIV/AIDS Cure Research; 4 Challenges for Using NHP/AIDS Models for HIV Cure Research; 4.1 Logistical Challenges; 4.2 Challenges in cART Administration to AIDS Virus Infected NHP; 5 Administration of Antiretroviral Drugs to NHPs | |
| 505 | 8 | |a 5.1 Antiretroviral Drugs That Have Been Utilized in NHPs5.2 Future cART Regimen Development for NHPs; 6 Alternative Models; 6.1 Chinese-Origin Rhesus Macaques; 6.2 RT-SHIV Infections; 6.3 SIVagm.sab Infections; 6.4 CNS Infection Models; 6.5 Envelope SHIVs; 7 Virologic Assays; 7.1 PCR and RT-PCR-Based Assays; 7.2 In Situ Approaches; 7.3 Other Virologic Assessments; 8 Concluding Remarks; Financial Support; References; 89 SIV Latency in Macrophages in the CNS; Abstract; 1 Introduction; 2 HIV Infection and SIV Infection in the CNS; 3 New Insights on Macrophage Origin and Phenotypes | |
| 520 | |a This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public. | ||
| 650 | 0 | |a HIV infections. |0 http://id.loc.gov/authorities/subjects/sh91004036 | |
| 650 | 0 | |a HIV (Viruses) |0 http://id.loc.gov/authorities/subjects/sh86004391 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Medical microbiology & virology. |2 bicssc | |
| 650 | 7 | |a Pathology. |2 bicssc | |
| 650 | 7 | |a Epidemiology & medical statistics. |2 bicssc | |
| 650 | 7 | |a Immunology. |2 bicssc | |
| 650 | 7 | |a HIV infections. |2 fast |0 (OCoLC)fst00949871 | |
| 650 | 7 | |a HIV (Viruses) |2 fast |0 (OCoLC)fst00949837 | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Silvestri, Guido |c (Professor of pathology and laboratory medicine), |e editor. |0 http://id.loc.gov/authorities/names/n2012182602 | |
| 700 | 1 | |a Lichterfeld, Mathias, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t HIV-1 latency. |d Cham, Switzerland : Springer, [2018] |z 3030028151 |z 9783030028152 |w (OCoLC)1054365701 |
| 830 | 0 | |a Current topics in microbiology and immunology ; |v 417. |0 http://id.loc.gov/authorities/names/n42036058 | |
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