Hyperpolarized and inert gas MRI : from technology to application in research and medicine /
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| Imprint: | Amsterdam : Elsevier, [2017] ©2017 |
|---|---|
| Description: | 1 online resource |
| Language: | English |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11736249 |
Table of Contents:
- Front Cover; Hyperpolarized and Inert Gas MRI; Copyright Page; Dedication; Contents; List of Contributors; Preface; Introduction; The Promise of Hyperpolarized-Gas MR Studies; The Choice of 3He or 129Xe; The Invention of Hyperpolarized-Gas MRI; Anecdotal Prolegomena; Progress in the Field; References; 1 MRI Acquisition Techniques; Nonequilibrium Magnetization; High Diffusivity; Signal Loss From Diffusion; Diffusion-Weighted Imaging; Relaxation Times and Partial Pressure of Oxygen; Design Considerations for GRE Imaging; Flip Angles and Phase-Encoding Order for Spoiled-GRE Pulse Sequences.
- Slice Profile and Slice OrderBalanced Steady-State Free Precession; 129Xe Gas Exchange and Uptake; Dissolved 129Xe in the Lung; Excitation Considerations; Taking Advantage of Chemical Shift; Closing Remarks; References; 2 The Physics of Hyperpolarized Gas MRI; Introduction; HP Gases: Properties and Considerations; General Properties; Spin Relaxation Mechanisms of HP Gases; Storage and Delivery Considerations for HP Gases; Pulse Sequence Considerations; Methods for Generating HP Gases; Dynamic Nuclear Polarization; Spin-Exchange Optical Pumping; SEOP History and Theoretical Background.
- SEOP InstrumentationStopped-Flow Polarizers; Continuous-Flow Polarizers; SEOP Gas Mixes and Operating Regimes; SEOP Characterization; Applications of SEOP-Prepared HP Gases; Metastability Exchange Optical Pumping; MEOP History and Theoretical Background; MEOP Laser Technology; MEOP Compressor Technology; MRI Applications of MEOP-Polarized Gases; Parahydrogen-Induced Polarization; Principles; PHIP Instrumentation; Potential for Biomedical Applications of HP Propane; HP Gases: Summary and Outlook; References; 3 Dynamic Imaging of Lung Ventilation and Gas Flow With Hyperpolarized Gas MRI.
- IntroductionMRI Methodology; Sequence Design and k-Space Sampling; 2D Single-Shot Sequences; 2D Multishot Sequences; 3D Dynamic Imaging; Physical Considerations for Dynamic Imaging; Spin Polarization; Breathing Factors; Local Static Magnetic Field Homogeneity; Localized Diffusion; Clinical and Physiological Applications of Dynamic HP Gas MRI; Quantification of Dynamic Data; Airway Caliber Measurement; Lung Motion; Flow Imaging; Time-Resolved Breath-Hold Imaging; Time-Resolved Multibreath Imaging; References; 4 Persistence of Ventilation Defects in Asthmatics; HP Gas MRI of the Normal Lung.
- HP Gas MRI in AsthmaVariable Versus Persistent Ventilation Defects; Appearance of Ventilation Defects Over Time; Effect of Bronchoconstricting Agent; Effect of Bronchodilators; Summary; References; 5 Hyperpolarized 3He Gas MRI Studies of Pulmonary Disease; Introduction; Emphysema; What Is It?; Hyperpolarized Noble Gas Diffusion-Weighted MRI; 3He MRI ADC: Anatomical and Technique Validation; 3He MRI ADC: Early Work; Airway Disease; What Is It?; Hyperpolarized 3He MRI Static Ventilation Imaging; 3He MRI Ventilation Defects: Anatomic and Technique Validation.