Acute neuronal injury : the role of excitotoxic programmed cell death mechanisms /

Acute neuronal injury : the role of excitotoxic programmed cell death mechanisms /

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Bibliographic Details
Edition:	Second edition.
Imprint:	Cham, Switzerland : Springer, [2018] ©2018
Description:	1 online resource : illustrations
Language:	English
Subject:	Nervous system -- Diseases -- Cytopathology. Cell death. Nervous System Diseases -- physiopathology. Cell Death -- physiology. Nervous System Diseases -- etiology. Neurons -- cytology. Apoptosis -- physiology. Cell death.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11736844

Hidden Bibliographic Details
Other authors / contributors:	Fujikawa, Denson G., editor.
ISBN:	9783319774954 3319774956 9783319774961 3319774964 9783030084684 303008468X 9783319774947 3319774948
Digital file characteristics:	text file PDF
Notes:	Includes bibliographical references. Vendor-supplied metadata.
Summary:	This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal.
Other form:	Print version: Acute neuronal injury. Second edition. Cham, Switzerland : Springer, [2018] 3319774948 9783319774947
Standard no.:	10.1007/978-3-319-77495-4 10.1007/978-3-319-77

Description
Summary:	An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. <br> The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
Physical Description:	1 online resource : illustrations
Bibliography:	Includes bibliographical references.
ISBN:	9783319774954 3319774956 9783319774961 3319774964 9783030084684 303008468X 9783319774947 3319774948