Advances in organic synthesis. Volume 7 /
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| Imprint: | Sharjah, U.A.E : Bentham Science Publishers, 2017. ©2017 |
|---|---|
| Description: | 1 online resource (ii, 272 pages) |
| Language: | English |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11759581 |
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| 245 | 0 | 0 | |a Advances in organic synthesis. |n Volume 7 / |c edited by Atta-ur-Rahman. |
| 264 | 1 | |a Sharjah, U.A.E : |b Bentham Science Publishers, |c 2017. | |
| 264 | 4 | |c ©2017 | |
| 300 | |a 1 online resource (ii, 272 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 500 | |a Title from PDF title page (viewed May 1, 2013). | ||
| 588 | 0 | |a Online resource; title from digital title page (viewed on May 04, 2018). | |
| 505 | 0 | |a Intro -- CONTENTS -- PREFACE -- List of Contributors -- Small Molecules that Ameliorate Protein Mis-folding -- Paolo Ruzza* -- INTRODUCTION -- Protein Folding -- SMALL MOLECULES -- Small Molecules that Act as Pharmacological Chaperones -- Lipid Storage Disorders -- Amyloid Related Diseases -- Cystic Fibrosis -- Small Molecules that Act as Osmolytes -- Trehalose -- Trimethylamine N-Oxide -- EVALUATION OF SMALL MOLECULES EFFECTS ON PROTEIN FOLDING -- Circular Dichroism (CD) Spectroscopy -- Nuclear Magnetic Resonance (NMR) Spectroscopy -- OUTLOOK -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Recent Advances in the Synthesis of Peptides and Proteins -- Riaz A. Khan1,2,*, Mamuna Naz1, Minhajul Arfeen1 and Nahid Abbas1 -- INTRODUCTION: THE BACKGROUND, SIGNIFICANCE & PROSPECTS -- PEPTIDES & PROTEINS: THE CHEMICAL CORE, BONDING & STRUCTURE -- INTRICACIES IN THE FORMATION OF AN AMIDE BOND -- COUPLING REAGENTS: ADVANCES & CONCURRENT APPROACHES -- REACTION MEDIUM: THE ROLE IN COUPLING -- ACTIVATION OF COUPLING REAGENTS -- COUPLING REACTIONS -- MONITORING OF COUPLING, AND DEBLOCKING -- DETERMINATION OF LOAD -- DETERMINATION OF THE EXTENT OF CLEAVAGE -- PROTECTION STRATEGIES: PROTECTING GROUP (PG) AS THE BEGINNING OF SYNTHESIS -- CHEMICAL SYNTHESIS OF PEPTIDES & PROTEINS: THE MAJOR STRATEGIES -- SOLUTION PHASE SYNTHESIS (SPS): THE CLASSICAL WET CHEMISTRY -- SOLID PHASE PEPTIDE SYNTHESIS: THE TURNING POINT & CONCURRENT ADVANCES -- SPPS: THE COMPONENTS OF THE OPERATION & SOLID SUPPORTS' REQUIRED CHARACTERISTICS -- CLEAVAGE FROM THE SOLID SUPPORT: THE ROLE OF LINKER -- SYNTHESIS & USE OF A VIABLE LINKER: SPPS OF A BACTERIAL ORIGIN OCTAPEPTIDE SEQUENCE -- APPROACHES FOR SPPS: ASPECTS OF EXPERIMENTAL METHODOLOGIES SEQUENTIAL SYNTHESIS -- CONVERGENT SYNTHESIS -- SYNTHETIC MODIFICATIONS OF PEPTIDES: THE STRUCTURAL DIVERSIFICATION. | |
| 505 | 8 | |a MODIFIED PEPTIDES: PHARMACEUTICALLY ACTIVE PEPTIDIC ENTITIES -- SYNTHESIS OF LONG-CHAIN PEPTIDES: EXAMPLES, ACCOMPLISHMENTS & CHALLENGES -- USE OF MICROWAVE IRRADIATION IN PEPTIDE SYNTHESIS -- THE LIGATION OF PEPTIDES: DEVELOPMENT OF NEW TECHNIQUES -- CHEMICAL LIGATION: PROTOTYPICAL PROCESS & EXPANSION OF APPROACH -- PREPARATION OF PEPTIDE C-TERMINAL THIOESTER BY BOC-SPPS METHOD -- PREPARATION OF PEPTIDE C-TERMINAL THIOESTERS BY FMOC-SPPS METHOD -- THE NATIVE CHEMICAL LIGATION (NCL) OR, TRANS-THIOESTERIFICATION -- CYSTEINE BASED STRATEGIES FOR NCL: PREPARATION OF NON-THIOL PEPTIDES -- APPROACH TO CYSTEINE SURROGATE: AUXILIARIES, SOLVENT, DETERGENT & SOLUBILIZING TAGS -- PEPTIDE LIGATION WITH SULFUR: PRIOR THIOL CAPTURE FOR 'NCL' -- ACYL-INITIATED CAPTURE: MAINTAINING 'CYS' AT LIGATION JUNCTION -- SERINE AND THREONINE BASED LIGATIONS -- APPROACHES WITH SELENIUM -- CONFORMATIONALLY ASSISTED LIGATION -- THE KAHA METHOD -- THE STAUDINGER LIGATION -- ONE-POT STRATEGIES FOR ASSEMBLING PEPTIDE FRAGMENTS -- MULTIPLE SEGMENT LIGATION STRATEGIES -- CONVENTIONAL & NON-CONVENTIONAL APPROACHES TO INVERSE SYNTHESIS: C-TO-N DIRECTION APPROACH -- N-TO-C DIRECTION APPROACH -- SYNTHESIS OF ACTIVATED PEPTIDES: OMER (O-MERCAPTOARYL ESTER REARRANGEMENT) APPROACH -- PREPARATION OF THIOPEPTIDES: INTRODUCTION OF DISULFIDE LINKAGES -- THE CYSTEINE-KNOT PEPTIDE SYNTHESIS -- SYNTHESIS OF CYCLIC PEPTIDES -- EXPRESSED PROTEIN LIGATION: THE BIOSYNTHESIS OF PEPTIDE FRAGMENT -- POST-TRANSLATIONALLY MODIFIED PROTEINS -- SYNTHESIS OF TRANSMEMBRANE (TM) PEPTIDES & PROTEINS SPECIFIC PROTOCOLS & TECHNIQUES: USE OF N-BACKBONE MODIFICATIONS -- ADDITION OF O-ACYL ISOPEPTIDE UNIT -- LIGATION STRATEGIES -- SITE-SPECIFIC MANIPULATION -- SYNTHESIS OF ISOTOPE-LABELED MEMBRANE PROTEINS -- CHEMICAL SYNTHESIS OF PROTEINS: RECENT EXAMPLES OF BIOACTIVE SEQUENCES ERYTHROPOIETIN. | |
| 505 | 8 | |a CHEMICAL SYNTHESIS OF INSULIN -- PROTEIN SYNTHESIS PROTOCOLS: EXPERIMENTAL AND PROCEDURAL ASPECTS -- FUNCTIONAL BIOCONJUGATES: JOINING PEPTIDES AND PROTEINS TOGETHER -- FOLDING OF SYNTHETIC POLYPEPTIDES: CONFORMATIONAL ASPECTS -- ANALYTICAL METHODS: THE CONFIRMATION OF SYNTHESIS & TERTIARY STRUCTURE -- BULK SYNTHESIS OF PEPTIDES & PROTEINS: THE SCALE-UP -- ENVIRONMENTAL IMPLICATIONS: THE FALL-OUT & NEEDED ADVANCEMENT(S) -- THE SCOPE & APPLICATIONS: PEPTIDES & PROTEINS IN MEDICINAL CHEMISTRY -- CURRENT ROLES & FUTURE PROSPECTS OF PROTEINS & PEPTIDES -- SUMMARY -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Bioorthogonal Coupling Strategies Used in Pretargeted Nuclear Imaging and Radiotherapy -- Justin J. Bailey1,*, Carmen Wängler2, Björn Wängler3 and Ralf Schirrmacher1 -- INTRODUCTION -- Non-Covalent Ligation Techniques -- Biotin/ (Strept) Avidin Coupling -- Bispecific Antibodies/Radiolabeled Haptens Coupling -- Chemical Ligation Techniques -- Staudinger Ligation -- Strain-Promoted Azide-Alkyne Cycloaddition -- Inverse Electron Demand Diels-Alder -- CONCLUSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Different Concepts of Catalysis in the Synthesis of Xanthenediones: A Brief Overview -- Milene Lopes da Silva1, Róbson Ricardo Teixeira1,* and Giovanni Wilson Amarante2 -- XANTHENEDIONES: IMPORTANCE AND SYNTHESIS -- CATALYSTS USED IN XANTHENEDIONE SYNTHESIS -- Lewis Acids -- Brønsted Acid -- Lewis and Brønsted acid -- Organocatalysts -- Ionic liquids -- Nanocatalysts -- CONCLUDING REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Heterogeneous Catalysts in Organic Synthesis: From Nanoscale to Single Atomic Level -- Min Li and Jingqi Guan* -- INTRODUCTION -- SYNTHESIS OF SINGLE ATOM CATALYST -- Atomic Layer Deposition -- Photochemical Technique -- Mass-Selected Soft-Landing Strategy. | |
| 505 | 8 | |a Chemical Reduction Method -- Co-precipitation Method -- Solid Melting Method -- Galvanic Replacement Reaction Method -- High Temperature Vapor Migration Approach -- Cyanide Leaching Method -- Impregnation Method -- Organometallic Complex Method -- Nitrogen Coordination Method -- Pyrolysis of MOFs -- Chemical Vapor Deposition -- PERFORMANCE OF SINGLE ATOM CATALYSTS -- High Activity -- Up to 100% Atomic Utilization -- Metal-Support Interaction -- Unsaturated Coordination Environment -- High Selectivity -- High Stability -- IDENTIFYING THE ACTIVE SITES -- APPLICATION OF SINGLE ATOM CATALYSTS -- CONCLUSIONS AND PERSPECTIVES -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- SUBJECT INDEX. | |
| 650 | 0 | |a Organic compounds |x Synthesis. |0 http://id.loc.gov/authorities/subjects/sh85023025 | |
| 650 | 7 | |a SCIENCE |x Chemistry |x Organic. |2 bisacsh | |
| 650 | 7 | |a Organic compounds |x Synthesis. |2 fast |0 (OCoLC)fst01047668 | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Rahman, Atta-ur-, |d 1942- |e editor. |0 http://id.loc.gov/authorities/names/n81151677 | |
| 776 | 0 | 8 | |i Print version: |a Atta-ur-Rahman. |t Advances in Organic Synthesis Volume 7. |d Sharjah : Bentham Science Publishers, ©2017 |z 9781681081588 |
| 903 | |a HeVa | ||
| 929 | |a oclccm | ||
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| 928 | |t Library of Congress classification |a QD262 .A38 2017 |l Online |c UC-FullText |u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=e000xna&AN=1621960 |z eBooks on EBSCOhost |g ebooks |i 12457442 | ||