HIV/AIDS-associated viral oncogenesis /
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Edition: | Second edition. |
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Imprint: | Cham, Switzerland : Springer, [2019] |
Description: | 1 online resource |
Language: | English |
Series: | Cancer treatment and research ; volume 177 Cancer treatment and research ; v. 177. |
Subject: | |
Format: | E-Resource Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11761355 |
Table of Contents:
- Intro; Contents; Overview; 1 AIDS-Associated Malignancies; Abstract; 1.1 Introduction; 1.2 Gammaherpesvirus-Associated Malignancies; 1.3 Human Papillomavirus-Associated Malignancies; 1.4 Conclusion; References; 2 Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis; Abstract; 2.1 Introduction; 2.2 KSHV Primary Infection; 2.2.1 Attachment, Entry, and Cellular Receptors; 2.2.2 Internalization and Intracellular Trafficking; 2.2.3 Regulation of Cellular Signaling Pathways During Primary Infection
- 2.2.4 Viral Gene Expression During Primary Infection and the Establishment of Viral Latency2.3 KSHV Life Cycle; 2.3.1 The Latency Locus; 2.3.2 KSHV Latency and Latent Nuclear Antigen (LNA) or Latency-Associated Nuclear Antigen (LANA); 2.3.3 Epigenetic Silencing and Regulation of KSHV Latency; 2.3.4 Reactivation of KSHV from Latency; 2.3.5 Viral Genes Required for Reactivation; 2.3.6 Factors Involved in KSHV Reactivation; 2.4 KSHV and Immunity; 2.4.1 KSHV and Innate Immunity; 2.4.2 KSHV and Adaptive Immunity; 2.5 KSHV and Tumorigenesis
- 2.5.1 Models of KSHV-Induced Cellular Transformation and Tumorigenesis2.5.2 KSHV Viral Genes and Tumorigenesis; 2.5.3 Cellular Genes/Pathways in KSHV-Associated Malignancies; 2.6 KSHV and Inflammation; 2.6.1 Kaposi's Sarcoma: A Tumor Associated with Inflammation; 2.6.2 Latent Viral Factors Involved in Inflammation; 2.6.3 Viral Lytic Genes Involved in Inflammation; 2.7 KSHV and Metabolism; 2.7.1 KSHV Reprograms Glucose Metabolism; 2.7.2 KSHV Reprogramming of Glutamine Metabolism for Host Cell Proliferation and Survival; 2.7.3 KSHV Infection Induces Lipogenesis
- 2.7.4 KSHV Depends on Glycolysis, Glutaminolysis, and FAS for Lytic Replication2.8 Conclusion and Perspectives; References; 3 Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Associated Disease in the AIDS Patient: An Update; Abstract; 3.1 Introduction; 3.2 KSHV and the Development of KS; 3.3 KSHV and the Development of Lymphomas; 3.4 Prevalence of Viral Infection; 3.5 The KSHV Genome; 3.6 Molecular Biology of KSHV-Associated Disease; 3.7 Therapies to Treat KS, PEL, and MCD; 3.8 Conclusions; Acknowledgements; References
- 4 Molecular Biology of EBV in Relationship to HIV/AIDS-Associated OncogenesisAbstract; 4.1 Introduction; 4.2 The Host Pathways Affected by EBV in Oncogenesis; 4.2.1 Resistance to Cell Apoptosis; 4.2.2 Cell Cycle and Proliferation; 4.2.3 Promotion of Cell Metabolism; 4.2.4 Evasion from Immune Surveillance; 4.2.5 Epigenetic Regulation Due to EBV Infection; 4.3 The Functions of EBV Proteins During Oncogenesis; 4.4 HIV-Associated Lymphoma in HIV/AIDS Patients; 4.5 Conclusions; References; 5 Human Papillomavirus Infection and Cervical Cancer in HIV+ Women; Abstract