Chaperokine activity of heat shock proteins /
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| Imprint: | Cham, Switzerland : Springer, 2019. |
|---|---|
| Description: | 1 online resource (ix, 320 pages) : illustrations (some color) |
| Language: | English |
| Series: | Heat shock proteins, 1877-1246 ; volume 16 Heat shock proteins (Series) ; v. 16. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11792348 |
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| 245 | 0 | 0 | |a Chaperokine activity of heat shock proteins / |c Alexzander A.A. Asea, Punit Kaur, editors. |
| 264 | 1 | |a Cham, Switzerland : |b Springer, |c 2019. | |
| 300 | |a 1 online resource (ix, 320 pages) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Heat shock proteins, |x 1877-1246 ; |v volume 16 | |
| 500 | |a Includes index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (SpringerLink, viewed February 7, 2019). | |
| 505 | 0 | |a Intro; Preface; Contents; Editors Biography; Part I: Immunological and Inflammatory Responses; Chapter 1: The Chaperokine Activity of Heat Shock Proteins; 1.1 Introduction; 1.1.1 Chaperokine-Induced Signal Transduction Pathways; 1.1.2 Biological Significance of Circulating Serum HAPA1A: Role in Host Physiology; 1.1.3 Application of Extracellular HSPA1A: HSPA12A-Based Immunotherapies; 1.1.4 Active Release Mechanism: Inflammation, Exercise, Psychological Stress, Brain and Cerebral Spinal Fluid (CSF); 1.1.5 Chaperokine-Mediated Inflammatory Responses; 1.1.6 Chaperokine Activity and Aging | |
| 505 | 8 | |a 3.3 Role of sHSP60 in Several Chronic Inflammatory Diseases3.3.1 Atherosclerosis; 3.3.2 Diabetes and Obesity; 3.3.3 Arthritis-Related Diseases; 3.4 Conclusions; References; Chapter 4: Heat Shock Protein 60: A Mediator of Atherosclerosis and Its Potential Therapeutic Role; 4.1 Introduction; 4.2 Heat Shock Proteins; 4.3 Heat Shock Protein 60 (HSP60); 4.4 Initiation of Immune Responses: The Chaperokine Activity of HSP60; 4.5 Early Atherosclerosis; 4.6 The "Autoimmune Concept of Atherosclerosis"; 4.7 HSP60 in Human Atherosclerosis; 4.8 HSP60-Induced Experimental Atherosclerosis | |
| 505 | 8 | |a 4.9 HSP60 Tolerization in Atherosclerosis4.10 HSP60 Tolerization in Other Autoimmune Diseases; 4.11 Conclusions; References; Chapter 5: Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases; 5.1 Introduction; 5.2 Rheumatoid Arthritis; 5.3 Systemic Lupus Erythematosus; 5.4 Idiopathic Inflammatory Myopathies; 5.5 Systemic Sclerosis; 5.6 Other Rheumatic Diseases; 5.7 Conclusions; References; Chapter 6: Upregulation of Cytoprotective Chaperones Mediate Better Tolerance to High Altitude; 6.1 Introduction; 6.1.1 High Altitude, Hypobaric Hypoxia and Oxidtive Stress | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a Chaperokine is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators such as cytokines, chemokines, nitric oxide, apotogenic mediators, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity. This edited book provides the most comprehensive review of contemporary knowledge of the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide an overview of novel mechanisms, signal transduction pathways and a concise understanding of how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present cutting-edge research activities and importantly, the future direction of chaperokine research. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychology, Human Physiology, Zoology, Botany, Biotechnology, Molecular Medicine, Infectious Disease, Pathology and Pharmaceutical Sciences, as well as for researchers involved in Drug Discovery. | ||
| 650 | 0 | |a Heat shock proteins. |0 http://id.loc.gov/authorities/subjects/sh85059812 | |
| 650 | 0 | |a Molecular chaperones. |0 http://id.loc.gov/authorities/subjects/sh95008221 | |
| 650 | 1 | 4 | |a Protein Science. |0 http://scigraph.springernature.com/things/product-market-codes/L14040 |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Heat shock proteins. |2 fast |0 (OCoLC)fst00953977 | |
| 650 | 7 | |a Molecular chaperones. |2 fast |0 (OCoLC)fst01024760 | |
| 655 | 0 | |a Electronic books. | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Asea, Alexzander A. A., |e editor. |0 http://id.loc.gov/authorities/names/nb2007018156 | |
| 700 | 1 | |a Kaur, Punit, |e editor. |0 http://id.loc.gov/authorities/names/n2015188829 | |
| 776 | 0 | 8 | |i Print version: |z 3030022536 |z 9783030022532 |w (OCoLC)1051676805 |
| 830 | 0 | |a Heat shock proteins (Series) ; |v v. 16. |x 1877-1246 |0 http://id.loc.gov/authorities/names/n2008180830 | |
| 880 | 8 | |6 505-00/(S |a 2.1.6 Extracellular Hsp70 Induces IFN-β in Brain Macrophages2.1.7 Exosomal Release of Hsp70 from Infected Cells; 2.1.8 Biological Implications of Hsp70 as a Virus-Induced Chaperokine; 2.2 Conclusions; References; Chapter 3: Biology of Extracellular HSP60; 3.1 Introduction; 3.2 Cellular HSP60 Activity; 3.2.1 Structure, Modifications and Chaperone Activity; 3.2.2 HSP60 in Apoptosis; 3.2.3 HSP60 Release in Extracellular Medium; 3.2.4 HSP60 in Innate Immune Response; 3.2.5 Action of HSP60 in Crosstalk Between Innate and Adaptive Immunity; 3.2.6 Receptor for sHSP60; 3.2.7 HSP60 and LPS | |
| 880 | 8 | |6 505-00/(S |a 1.1.7 HSP-Peptide Complexes (HSPPC) as Immunotherapy for Cancer1.2 Conclusions; References; Chapter 2: Extracellular HSP70, Neuroinflammation and Protection Against Viral Virulence; 2.1 Introduction; 2.1.1 Non-cytolytic Neuronal Infection by Measles Virus; 2.1.2 HSP70 Expression Levels and the Study of Neurovirulence; 2.1.3 HSP70 Supports Virus Gene Expression; 2.1.4 HSP70 Protects Against Measles Virus Neurovirulence in an IFN-β Dependent Manner; 2.1.5 HSP70 Protects Against Vesicular Stomatitis Virus Neurovirulence in an IFN-β Dependent Manner | |
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