Fc mediated activity of antibodies : structural and functional diversity /

Fc mediated activity of antibodies : structural and functional diversity /

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Bibliographic Details
Imprint:	Cham : Springer, 2019.
Description:	1 online resource (155 pages)
Language:	English
Series:	Current topics in microbiology and immunology, 2196-9965 ; v. 423 Current topics in microbiology and immunology ; 423.
Subject:	Fc receptors. Immunoglobulins. Autoimmune diseases. Autoimmune diseases. Fc receptors. Immunoglobulins. Electronic books.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11956193

Hidden Bibliographic Details
Other authors / contributors:	Ravetch, J. V. (Jeffrey V.), 1951- Nimmerjahn, Falk.
ISBN:	9783030310530 3030310531
Digital file characteristics:	text file PDF
Notes:	Includes bibliographical references. Online resource; title from PDF title page (SpringerLink, viewed September 20, 2019).
Summary:	This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
Other form:	Print version: Ravetch, Jeffrey V. Fc Mediated Activity of Antibodies : Structural and Functional Diversity. Cham : Springer, ©2019 9783030310523
Standard no.:	10.1007/978-3-030-31 10.1007/978-3-030-31053-0

Table of Contents:

IgG Fc receptors: evolutionary considerations
Role of FcgRs in Antibody Based Cancer Therapy
Anti-inflammatory Activity of IgG-Fc
IgG Fc glycosylation in human immunity
IgE Glycosylation in Health and Disease
Immune Complex Vaccination
Fc receptors in anti-microbial protection.