Proteomic and ionomic study for identification of biomarkers in biological fluid samples of patients with psychiatric disorders and healthy individuals /

Proteomic and ionomic study for identification of biomarkers in biological fluid samples of patients with psychiatric disorders and healthy individuals /

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Bibliographic Details
Author / Creator:Romário de Jesus, Jemmyson, author.
Imprint:Cham : Springer, [2019]
©2019
Description:1 online resource
Language:English
Series:Springer theses, 2190-5053
Springer theses.
Subject:
Biochemical markers.
Proteomics.
Mental illness.
Biochemical markers.
Mental illness.
Proteomics.
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11981913
Hidden Bibliographic Details
ISBN:9783030294731
3030294730
9783030294724
3030294722
9783030294724
9783030294748
3030294749
9783030294755
3030294757
Digital file characteristics:text file PDF
Notes:"Doctoral thesis accepted by the University of Campinas, Campinas, Brazil."
Includes bibliographical references.
Online resource; title from PDF title page (SpringerLink, viewed October 31, 2019).
Summary:This book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD. Bipolar disorder is a psychiatric condition that affects thousands of people worldwide. The absence of biomarkers for BD has resulted in misdiagnosis and ineffective treatment in some patients, causing additional health problems and high costs for health systems. As such, this book evaluates various strategies for sample preparation for proteomic and ionomic studies in order to simplify complex serum samples and allow the quantification of chemical species (proteins and metal ions), which are potential candidates for BD biomarkers. In addition, it describes the development of a new membrane-based methodology for extracting urine proteins to be used in biomarker discovery.
Other form:Printed edition: 9783030294724
Printed edition: 9783030294748
Printed edition: 9783030294755
Standard no.:10.1007/978-3-030-29473-1
Table of Contents:
  • Introduction
  • Application of a Proteomic Strategy for the Identification of Differential Proteins Candidates to Biomarkers of Bipolar Disorder
  • Application of the Ionomic Strategy to Evaluate Possible Differences in Metal Ion Concentration Between Patients with Bipolar Disorder and other Psychiatric Disorders
  • Development of a New Polymer Membrane Based Methodology for Characterization of the Urine Proteome
  • Final Conclusion.

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