From Artemisia annua L. to Artemisinins : the discovery and development of artemisinins and antimalarial agents /

From Artemisia annua L. to Artemisinins : the discovery and development of artemisinins and antimalarial agents /

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Bibliographic Details
Author / Creator:Tu, Youyou, 1930- author.
Imprint:London ; San Diego : Chemical Industry Press : Academic Press, [2017]
Description:1 online resource
Language:English
Subject:
Artemisinin.
Antimalarials.
Artemisia annua.
Artemisinins.
Antimalarials.
Artemisia annua.
Artemisinin.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/12315416
Hidden Bibliographic Details
ISBN:9780128116562
0128116560
9780128116555
0128116552
Notes:Includes index.
Includes bibliographical references and index.
Summary:From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research.
Other form:Print version: 9780128116555 0128116552
Table of Contents:
  • Cover
  • Title Page
  • Copyright Page
  • Contents
  • About the Author
  • List of Contributors
  • Foreword
  • Preface
  • The Discovery History of Artemisinin
  • 1
  • Discovery of Antimalarial Effect of Artemisinin
  • 2
  • Structural Identification and Structure-Activity Relationship Research of Artemisinin and Derivatives
  • 3
  • Artemisinin-A Gift From Traditional Chinese Medicine to the World
  • Part 1
  • Artemisia annua L.
  • Chapter 1
  • Introduction
  • 1
  • The History of Artemisia annua L. and Its Antimalarial Efficacy
  • References
  • Further Reading
  • Chapter 2
  • Studies of the Certified and Confused Herba Artemisiae Annuae
  • 1
  • A Revision of the Chinese Name of the Sweet Wormwood Plant
  • 2
  • Market Research on the Commercial Herba Artemisiae Annuae
  • 3
  • Original Plants of Artemisia annua L. and Its Five Confused Congeners
  • 3.1
  • Artemisia annua L.
  • 3.2
  • Artemisia apiacea Hance
  • 3.3
  • Artemisia scoparia Waldst. et Kit.
  • 3.4
  • Artemisia capillaris Thunb
  • 3.5
  • Artemisia japonica Thunb
  • 3.6
  • Artemisia eriopoda Bunge
  • 4
  • Pharmacognostical and Physicochemical Studies of Artemisia annua L. and Its Five Confused Congeners
  • 4.1
  • Artemisia annua L.
  • 4.2
  • Artemisia apiacea Hance
  • 4.3
  • Artemisia scoparia Waldst. et Kit.
  • 4.4
  • Artemisia capillaris Thunb
  • 4.5
  • Artemisia eriopoda Bunge
  • 4.6
  • Artemisia japonica Thunb
  • 5
  • Thin-Layer Chromatography (TLC)
  • 6
  • Study of Chemical Constituents of A. annua L. and Its Confused Congeners
  • 7
  • Dynamic Research on Chemical Constituents of A. annua L.
  • References
  • Chapter 3
  • Research on Artemisia annua L. for the Treatment of Malaria
  • 1
  • Researches on Active Antimalarial Ingredients in Herbs
  • 1.1
  • Exploration and Identification
  • 1.2
  • Research on Pharmacodynamics of Active Neutral Moiety in Artemisia annua L.
  • 1.2.1
  • Plasmodium berghei.
  • 1.2.2
  • Plasmodium inui (Plasmodium cynomolgi)
  • 1.3
  • Researches on the Safety of Neutral Moiety in Artemisia annua L.
  • 1.3.1
  • Acute toxicity
  • 1.3.2
  • Effect on the heart
  • 1.3.3
  • Effect on the liver
  • 1.3.4
  • Effect on kidneys
  • 1.3.5
  • Pathological examination
  • 1.3.6
  • Human trials
  • 1.4
  • First Research on Clinical Efficacy of Active Neutral Moiety in Artemisia annua L.
  • 2
  • Separation and Purification of the Active Ingredient (Artemisinin) and Determination of Its Antimalarial Efficacy and Chemical Structure
  • 2.1
  • Discovery of Artemisinin
  • 2.2
  • Researches on Safety of Artemisinin and Determination of Clinical Antimalarial Effect
  • 2.2.1
  • Acute toxicity test
  • 2.2.2
  • Effect on heart
  • 2.2.3
  • Effect on liver
  • 2.2.4
  • Histopathological examination
  • 2.2.5
  • Observation of toxic and side effect in human trials
  • 2.3
  • Identification of the Chemical Structure of Artemisinin
  • 3
  • First Measurement of Absolute Configuration of Artemisinin With Anomalous Scattering of Oxygen Atom in China
  • 3.1
  • Experiment and Data Processing
  • 3.2
  • Determination of Structure
  • 3.3
  • Amendment of Structure
  • 3.4
  • Determination of Absolute Configuration
  • Chapter 4
  • Advancement in Researches on Chemical Ingredients in Artemisia annua L.
  • 1
  • Terpenoids
  • 1.1
  • Sesquiterpenes-Like Compounds
  • 1.2
  • Other Terpenoids
  • 2
  • Other Compounds
  • 2.1
  • Coumarins
  • 2.2
  • Flavonoids
  • 2.3
  • Aliphatic and Enyne Compounds
  • 2.4
  • Others
  • 3
  • Gas Chromatography Analysis of Volatile Oils
  • References
  • Chapter 5
  • Studies on Quality Control of Qinghao
  • 1
  • Artemisinin
  • 1.1
  • Identification of Artemisinin in Qinghao by TLC
  • 1.2
  • Determination of Artemisinin in Qinghao (Aerial Part of Artemisia annua L.)
  • 1.2.1
  • Chemicals, reagents, and materials
  • 1.2.2
  • Apparatus and chromatographic conditions.
  • 1.2.3
  • Reference solution and calibration curve
  • 1.2.4
  • Test solution
  • 1.2.5
  • Precision
  • 1.2.6
  • Stability
  • 1.2.7
  • Repeatability
  • 1.2.8
  • Recovery
  • 1.2.9
  • Quantitative determination of artemisinin in Qinghao
  • 2
  • Scopoletin
  • 2.1
  • Identification of Scopoletin in Qinghao by TLC
  • 2.2
  • Determination of Scopoletin in Qinghao (Aerial Part of Artemisia annua L.)
  • 2.2.1
  • Chemicals, reagents, and materials
  • 2.2.2
  • Apparatus and chromatographic conditions
  • 2.2.3
  • Reference solution and calibration curve
  • 2.2.4
  • Test solution
  • 2.2.5
  • Precision
  • 2.2.6
  • Repeatability and stability
  • 2.2.7
  • Recovery
  • 2.2.8
  • Quantitative determination of scopoletin in Qinghao
  • Reference
  • Chapter 6
  • Studies on Pharmacological Actions of Artemisia annua
  • 1
  • Studies on Antipyretic, Heat-Resistant, Antiinflammatory, Analgesic, and Antimicrobial Actions of Artemisia annua
  • 1.1
  • Water-Extracted Portion
  • 1.1.1
  • Fever reduction test
  • 1.1.2
  • High temperature resistance test
  • 1.1.3
  • Antiinflammation test
  • 1.1.4
  • Pain relief test
  • 1.2
  • Solvent-Extracted Portion
  • 1.2.1
  • Fever reduction test
  • 1.2.2
  • High temperature resistance test
  • 1.2.3
  • Antiinflammation test
  • 1.3
  • Antiinflammation Test of Scopoletin
  • 1.4
  • Antimicrobial Tests
  • 1.4.1
  • Methods
  • 1.4.2
  • Results
  • 1.5
  • Acute Toxicity Test
  • 2
  • Studies on Pharmacological Actions of Volatile Oils of Artemisia annua
  • 2.1
  • Studies on Expectorant, Antitussive, and Antiasthmatic Actions
  • 2.2
  • Toxicity Tests of Volatile Oils of Artemisia annua
  • 2.2.1
  • Acute toxicity test
  • 2.2.2
  • Subacute toxicity test
  • 2.2.3
  • Effect of volatile oils of Artemisia annua on serum alanine transaminase level
  • 2.2.4
  • Conclusions
  • 2.3
  • Formulation Studies
  • 2.3.1
  • Formula
  • 2.3.2
  • Preparation
  • 2.4
  • Clinical Studies.
  • 3
  • Progress in Pharmacological Action Studies and Clinical Application of Artemisia annua
  • 3.1
  • Immunomodulation Function
  • 3.2
  • Antischistosoma Activity
  • 3.3
  • Antiviral Action
  • 3.4
  • Antimicrobial Action
  • 3.5
  • Antiendotoxin Action
  • 3.6
  • Pharmacological Action of Artemisia annua Prescriptions
  • 3.7
  • Antifeedant Activity Against Pests
  • 3.8
  • Other Biological Activities and Clinical Application
  • References
  • Chapter 7
  • Studies on the Cultivation and Breeding of Artemisia annua L.
  • 1
  • Biological Characteristics of Artemisia annua and Its Progress
  • 1.1
  • Cultivation of Artemisia annua
  • 1.1.1
  • Harvest
  • 1.1.2
  • Postharvest handling
  • 1.2
  • Reproductive Physiology of Artemisia annua
  • 1.3
  • Physiology and Biochemistry of Artemisia annua
  • 1.4
  • Structural, Biochemical, and Physiological Functions of the Glandular Trichomes of Artemisia annua
  • 1.5
  • Genetic Improvement
  • 2
  • Tissue Culture of Artemisia annua L.
  • 2.1
  • Callus Induction and Plant Regeneration
  • 2.2
  • Determination of Artemisinin Content
  • 3
  • Hairy Root Cultures of Artemisia annua L.
  • 3.1
  • Hairy Root, Untransformed Root, and Callus Cultures of Artemisia annua
  • 3.2
  • Selection of Artemisinin High-Yielding Hairy Root Lines
  • 3.3
  • Dynamics of Growth and Artemisinin Biosynthesis of Hairy Root of Artemisia annua
  • 4
  • Induction of Shoot Clusters of Artemisia annua L.
  • 4.1
  • Factors Influencing the Induction of Artemisia annua Shoot Clusters
  • 4.1.1
  • Effects of medium components on the induction rate of shoot clusters
  • 4.1.2
  • Differences of shoot clusters induction rate in explants of different culture time and different genotypes
  • 4.1.3
  • Effects of light, temperature, and photoperiod on the induction of shoot clusters
  • 4.2
  • Regulation of Physicochemical Factors on the Growth of Shoot Clusters and Artemisinin Biosynthesis.
  • 4.2.1
  • Effect of constituents of culture medium on the growth of shoot clusters and artemisinin biosynthesis
  • 4.2.1.1
  • Inorganic constituents
  • 4.2.1.2
  • Other constituents
  • 4.2.2
  • Effects of light, temperature, and growth cycle on the growth of shoot clustersand artemisinin biosynthesis
  • 5
  • Artemisinin Production in Bioreactors
  • 6
  • Space Breeding of Artemisia annua L.
  • 6.1
  • Screening of Space-High-Yield Strain
  • 6.2
  • Field Cultivation of Space-High-Yield Strain SP-18
  • 6.3
  • Comparison of Artemisinin Content of SP-18 Planted in the South and in the North of China
  • Acknowledgments
  • References
  • Chapter 8
  • Metabolic Engineering of Artemisia annua L.
  • 1
  • Progress in the Molecular Regulation of Artemisinin Biosynthesis
  • 1.1
  • The Biosynthetic Pathway of Artemisinin
  • 1.1.1
  • From acetyl-CoA to farnesyl diphosphate (FPP)
  • 1.1.2
  • From farnesyl diphosphate to artemisinin
  • 1.2
  • Related Enzymes of Artemisinin Biosynthesis
  • 1.2.1
  • 3-Hydroxy-3-methylglutaryl CoA reductase (HMGR)
  • 1.2.2
  • Farnesyl diphosphate synthase (FPS)
  • 1.2.3
  • Sesquiterpene synthase (cyclase)
  • 1.2.3.1
  • Separation and purification of amorpha-4,11-diene synthase
  • 1.2.3.2
  • Gene cloning, function analysis, and heterologous expression of amorpha-4,11-diene synthase
  • 1.2.4
  • Amorpha-4,11-diene hydroxylase (cytochrome P450 monooxygenase)
  • 1.2.5
  • Artemisinic aldehyde ∆11(13) double bond reductase (DBR2)
  • 1.2.6
  • Aldehyde dehydrogenase (ALDH1)
  • 1.2.7
  • Alcohol dehydrogenase (ADH1)
  • 1.2.8
  • Dihydroartemisinic aldehyde reductase (Red1)
  • 1.2.9
  • Cinnamyl alcohol dehydrogenase (CAD)
  • 1.3
  • Gene Regulation of Artemisinin Biosynthesis
  • 2
  • Establishment of Genetic Transformation System of Artemisia annua
  • 2.1
  • Ri Plasmid-Mediated Genetic Transformation of Artemisia annua.
  • 2.1.1
  • Effects of different Agrobacterium rhizogenes on the morphology and induction rate of hairy roots.

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