HIV-I : molecular biology and pathogenesis : clinical applications /
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| Edition: | 2nd ed. / edited by J. Thomas Aug., Ferid Murad and Kuan-Teh Jeang. |
|---|---|
| Imprint: | Amsterdam ; Boston : Elsevier/Academic Press, 2008. |
| Description: | 1 online resource (593 pages) |
| Language: | English |
| Series: | Advances in pharmacology ; vol. 56 Advances in pharmacology ; vol. 56. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12377427 |
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| 245 | 0 | 0 | |a HIV-I : molecular biology and pathogenesis : |b clinical applications / |c edited by Kuan-Teh Jeang. |
| 246 | 3 | |a Clinical applications | |
| 250 | |a 2nd ed. / |b edited by J. Thomas Aug., Ferid Murad and Kuan-Teh Jeang. | ||
| 260 | |a Amsterdam ; |a Boston : |b Elsevier/Academic Press, |c 2008. | ||
| 300 | |a 1 online resource (593 pages) | ||
| 336 | |a text |b txt |2 rdacontent |0 http://id.loc.gov/vocabulary/contentTypes/txt | ||
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| 490 | 1 | |a Advances in pharmacology ; |v vol. 56 | |
| 500 | |a Previous edition: 2000. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a Although it is one of the most-widely studied viruses, many mysteries still remain about HIV. Covering the latest advances and challenges associated with clinical application of new antiviral drugs and vaccines, this revised edition is a companion to Murad:HIV-1: Molecular Biology and Pathogenesis, 2E. Leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. * The latest developments in HIV-vaccine research * New concepts in the discovery and design of novel anti-HIV drugs. | ||
| 505 | 0 | |a Front Cover; HIV-1: Molecular Biology and Pathogenesis; Copyright Page; Contents; Contributors; Preface written by Robin A. Weiss; A. HIV Types (HIV-1 and HIV-2); B. Genotype Classification of HIV-1s; C. HIV-2: Genotype Classification and Geographic Distribution; A. Global HIV-1 Variability; B. HIV-1 Variants in Asia; C. Other HIV-1 Variants of Geographical Relevance; D. Emergence og HIV-1 Recombinants Worldwide; A. Phylogenetic Sequeuce Analysis; B. Alternative Methods (Heteroduplex Mobility Assay and Serotyping); VI. Origin of HIVs and Genesis of HIV-1 Pandemic. | |
| 505 | 8 | |a A. HIV/AIDS as a ""Zoonosis""B. Dating the Origin of Pandemic HIV-1 Strains; A. HIV-1 Subtypes and Disease Progression; B. HIV-1 Dual Infection, Superinfection, and Recombination; C. Biological Implications of Recombination; Acknowledgments; References; B. Nonnucleoside Reverse Transcriptase Inhibitors; C. Protease Inhibitors; A. Initiation of Therapy; B. Initial Regimen; C. Long-Term Management; D. Resistance; E. Drugs in Development; IV. Conclusion; References; A. Protective Role of HIV-1-Specific T-Cell Responses; B. Kinetics of HIV-1-Specific T-Cell Responses in Primary Infection. | |
| 505 | 8 | |a C. Phenotypic and Functional Profiles of HIV-1-Specific CD4 and CD8 T-Cell ResponsesD. Phenotype; E. Function; F. Specificity and Breadth of HIV-1-Specific T-Cell Responses; References; II. Background; III. Inhibition of Viral Attachment; A. gp120 Inhibitors; B. Targeting CD4; IV. Chemokine Receptors in HIV Infection; V. Targeting Coreceptor Binding; A. CXCR4 Inhibition; B. Targeting CCR5 for HIV Therapy; VI. Fusion Inhibitors; A. Targeting gp41; B. Inhibition of Membrane Fusion; VII. Resistance to Inhibitors of Viral Entry; VIII. Use Entry Inhibitors as Microbicides; References. | |
| 505 | 8 | |a B. Mechanism of HIV-1 RT DNA Polymerase ActivityA. Mechanisms of NRTI Inhibition; B. NRTI Approved for Clinical Use; C. Investigational NRTI; D. HIV-1 Resistance to NRTIs; V. Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs); A. Mechanisms of NNRTI Inhibition; B. NNRTI Approved for Clinical Use; C. Investigational NNRTI; D. HIV-1 Resistance to NNRTIs; E. Interactions Between NNRTI and NRTI Resistance Mutations; F. Use of NNRTI as Microbicides; VI. Other Inhibitors of HIV-1 RT; A. Inhibitors of HIV-1 RT RNH; B. Inhibitors of HIV-1 RT Dimerization. | |
| 505 | 8 | |a C. Inhibitors of the Initiation of Reverse TranscriptionD. RT-Directed Mutagenic Inducers; VII. Conclusion; Acknowledgments; References; A. Mechanism of Action of PIs; B. Protease Structures and Substrate-Based Inhibitors; C. Design of Symmetry-Based Inhibitors; D. Structure-Based PIs; A. Emergence of Drug Resistance to PIs; B. Primary and Secondary Mutations; C. Active site Mutants; D. Nonactive Site Mutants; E. Cleavage Site Mutants; F. Noncleavage Site Mutants; G. Insertions in Gag-Pol Polyproteins; VII. PIs with Activity Against Drug-Resistant HIV-1. | |
| 546 | |a Text in English. | ||
| 650 | 0 | |a HIV infections |x Molecular aspects. | |
| 650 | 0 | |a HIV infections |x Pathogenesis. | |
| 650 | 0 | |a HIV infections |x Treatment. | |
| 650 | 0 | |a AIDS vaccines. |0 http://id.loc.gov/authorities/subjects/sh88007929 | |
| 650 | 7 | |a MEDICAL |x AIDS & HIV. |2 bisacsh | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x AIDS & HIV. |2 bisacsh | |
| 650 | 7 | |a AIDS vaccines. |2 fast |0 (OCoLC)fst00794025 | |
| 650 | 7 | |a HIV infections |x Pathogenesis. |2 fast |0 (OCoLC)fst00949893 | |
| 650 | 7 | |a HIV infections |x Treatment. |2 fast |0 (OCoLC)fst00949907 | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a August, J. Thomas. |0 http://id.loc.gov/authorities/names/n82109264 |1 http://viaf.org/viaf/61635486 | |
| 700 | 1 | |a Murad, Ferid. |0 http://id.loc.gov/authorities/names/no96063323 |1 http://viaf.org/viaf/166185358 | |
| 700 | 1 | |a Jeang, Kuan-Teh. |0 http://id.loc.gov/authorities/names/n86822246 |1 http://viaf.org/viaf/53185299 | |
| 776 | 0 | 8 | |i Print version: |t HIV-I : molecular biology and pathogenesis. |b 2nd ed. |d Amsterdam ; Boston : Elsevier/Academic Press, 2008 |z 9780123736017 |z 0123736013 |w (OCoLC)174129525 |
| 830 | 0 | |a Advances in pharmacology ; |v vol. 56. | |
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| 928 | |t Library of Congress classification |a QR201.A37 H58 2008eb |l Online |c UC-FullText |u https://www.sciencedirect.com/science/bookseries/10543589/56 |z Elsevier |g ebooks |i 11977418 | ||