WNT signaling in health and disease /
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| Edition: | First edition. |
|---|---|
| Imprint: | London, United Kingdom : Academic Press, 2018. |
| Description: | 1 online resource : color illustrations. |
| Language: | English |
| Series: | Progress in molecular biology and translational science ; volume 153 Progress in molecular biology and translational science ; v. 153. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12379043 |
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| 245 | 0 | 0 | |a WNT signaling in health and disease / |c edited by Juan Larraín, Gonzalo Olivares. |
| 250 | |a First edition. | ||
| 264 | 1 | |a London, United Kingdom : |b Academic Press, |c 2018. | |
| 300 | |a 1 online resource : |b color illustrations. | ||
| 336 | |a text |b txt |2 rdacontent |0 http://id.loc.gov/vocabulary/contentTypes/txt | ||
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| 490 | 1 | |a Progress in molecular biology and translational science ; |v volume 153 | |
| 588 | 0 | |a Vendor-supplied metadata. | |
| 505 | 0 | 0 | |6 880-01 |t Wnt Ligands as a Part of the Stem Cell Niche in the Intestine and the Liver / |r Bahar Degirmenci, George Hausmann, Tomas Valenta, Konrad Basler -- |t Wnt Signaling in Adult Epithelial Stem Cells and Cancer / |r Si Hui Tan, Nick Barker -- |t Wnt Signaling in the Central Nervous System: New Insights in Health and Disease / |r Carolina A. Oliva, Carla Montecinos-Oliva, Nibaldo C. Inestrosa -- |t Of Wnts and Ribosomes / |r Astrid S. Pfister, Michael Kühl -- |t Wnt Signaling in Skeletal Muscle Development and Regeneration / |r Francesco Girardi, Fabien Le Grand -- |t Wnt Signaling in Kidney Development and Disease / |r Yongping Wang, Chengji J. Zhou, Youhua Liu -- |t Wnt Signaling in Stem Cells and Cancer Stem Cells: A Tale of Two Coactivators / |r Michael Kahn -- |t Chemical Modulation of WNT Signaling in Cancer / |r Li-shu Zhang, Lawrence Lum -- |t The Wnt Signaling Landscape of Mammary Stem Cells and Breast Tumors / |r Caroline M. Alexander -- |t The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy / |r Elizabeth Vincan, Renate H.M. Schwab, Dustin J. Flanagan, Jean M. Moselen, Bang Manh Tran, Nick Barker, Toby J. Phesse -- |t Wnt Signaling in Hematological Malignancies / |r Stephanie Grainger, David Traver, Karl Willert. |
| 520 | |a WNT Signaling, Volume 153, the latest release in the Progress in Molecular Biology and Translational Science series, seeks to provide the most topical, informative, and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series provides readers with in-depth knowledge of important molecular biological aspects of organismal physiology and function, along with insights into how this knowledge may be applied to understand and ameliorate human disease. Each volume is edited by an internationally recognized expert who selects contributors at the forefront of a field. | ||
| 650 | 0 | |a Cellular signal transduction. |0 http://id.loc.gov/authorities/subjects/sh89002397 | |
| 650 | 0 | |a Wnt proteins. |0 http://id.loc.gov/authorities/subjects/sh2003001148 | |
| 650 | 0 | |a Wnt genes. |0 http://id.loc.gov/authorities/subjects/sh2003001478 | |
| 650 | 0 | |a Molecular biology. |0 http://id.loc.gov/authorities/subjects/sh85086577 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Cellular signal transduction. |2 fast |0 (OCoLC)fst00850288 | |
| 650 | 7 | |a Molecular biology. |2 fast |0 (OCoLC)fst01024734 | |
| 650 | 7 | |a Wnt genes. |2 fast |0 (OCoLC)fst01176457 | |
| 650 | 7 | |a Wnt proteins. |2 fast |0 (OCoLC)fst01176458 | |
| 650 | 2 | |a Wnt Signaling Pathway. | |
| 650 | 2 | |a Wnt Proteins. | |
| 650 | 2 | |a Receptors, Wnt. | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Larraín, Juan, |e editor. |1 http://viaf.org/viaf/6833155286654287180006 | |
| 700 | 1 | |a Olivares, Gonzalo, |e editor. | |
| 830 | 0 | |a Progress in molecular biology and translational science ; |v v. 153. |0 http://id.loc.gov/authorities/names/no2009049039 | |
| 880 | 0 | 0 | |6 505-01/(S |g Machine generated contents note: |g 1. |t Wnt Ligands as a Part of the Stem Cell Niche in the Intestine and the Liver / |r Konrad Basler -- |g 1. |t Introduction -- |g 2. |t Overview of Wnt Signaling -- |g 3. |t Intestine -- |g 4. |t Liver -- |g 5. |t Concluding Remarks -- |t References -- |g 2. |t Wnt Signaling in Adult Epithelial Stem Cells and Cancer / |r Nick Barker -- |g 1. |t Introduction -- |g 2. |t Gastrointestinal Stem Cells and Cancer -- |g 3. |t Skin Stem Cells and Cancer -- |g 4. |t Liver Stem Cells and Cancer -- |g 5. |t Concluding Remarks -- |t References -- |g 3. |t Wnt Signaling in the Central Nervous System: New Insights in Health and Disease / |r Nibaldo C. Inestrosa -- |g 1. |t Introduction -- |g 2. |t Wnt Expression in the Postnatal and Adult CNS -- |g 3. |t Wnt Function in the Developing and Mature CNS -- |g 4. |t Wnt Effect in Neuronal Processing -- |g 5. |t Wnt Signaling Dysfunction in Neurodegeneration and Mental Disorders -- |g 6. |t Concluding Remarks -- |t References -- |g 4. |t Of Wnts and Ribosomes / |r Michael Kuhl -- |g 1. |t Introduction -- |g 2. |t Target Genes of Wnt Signaling Involved in Ribosome Biogenesis -- |g 3. |t Regulators of Ribosome Biogenesis and Nucleolar Factors as Modifiers of Wnt Signaling -- |g 4. |t Noncanonical Wnt Signaling Regulates Nucleolar Size -- |g 5. |t Wnt Regulates Ribosome Composition -- |g 6. |t Closing Remarks -- |t References -- |g 5. |t Wnt Signaling in Skeletal Muscle Development and Regeneration / |r Fabien Le Grand -- |g 1. |t Wnt Signaling Pathways -- |g 2. |t Skeletal Muscle Development -- |g 3. |t Wnt Signaling in Skeletal Muscle Development -- |g 4. |t Skeletal Muscle Regeneration -- |g 5. |t Wnt Signaling in Skeletal Muscle Regeneration -- |g 6. |t Control of Myofiber Typing by Wnt Signaling -- |g 7. |t Crosstalk Between Wnt and TGFβ Signaling in Skeletal Muscle -- |g 8. |t Wnt Signaling Implications in Muscular Disease and Treatment -- |g 9. |t Concluding Remarks and Outstanding Questions -- |t Acknowledgments -- |t References -- |g 6. |t Wnt Signaling in Kidney Development and Disease / |r Youhua Liu -- |g 1. |t Introduction -- |g 2. |t Wnt Signaling: Components and Routes -- |g 3. |t Wnt Signaling and Kidney Development -- |g 4. |t Wnt Signaling and Kidney Diseases -- |g 5. |t Conclusions -- |t Acknowledgments -- |t References -- |g 7. |t Wnt Signaling in Stem Cells and Cancer Stem Cells: A Tale of Two Coactivators / |r Michael Kahn -- |g 1. |t Introduction -- |g 2. |t Wnt Signaling Pathways in Stem Cell Biology -- |g 3. |t Embryonic and Induced Pluripotent Stem Cells -- |g 4. |t Somatic Stem Cells (SSC) -- |g 5. |t Symmetric or Asymmetric Division: That is the Question -- |g 6. |t Cancer Stem Cells (CSC) -- |g 7. |t SSCs and CSCs; More Similarities than Differences -- |g 8. |t Extremely Critical Decision -- |g 9. |t Differential Coactivator Modulation -- |g 10. |t Pharmacologically Manipulating SSC and CSC -- |g 11. |t CBP/Catenin Antagonists in the Clinic -- |g 12. |t CBP/Catenin Antagonists: Targeting CSCs Achilles' Heel-- |g 13. |t Aging and Aging Stem Cells and Wnt Signaling -- |g 14. |t Kat3A/CBP and Kat3B/p300 Evolutionary Rationale -- |g 15. |t Conclusions and Future Prospects -- |t Acknowledgments -- |t References -- |g 8. |t Chemical Modulation of WNT Signaling in Cancer / |r Lawrence Lum -- |g 1. |t Introduction -- |g 2. |t Development of PORCN Inhibitors as WNT Signaling Antagonism -- |g 3. |t Normal Tissue Responses to Transient WNT Signaling Suppression -- |g 4. |t WNT Inhibitors and their Potential Utility in Solid Tumors -- |g 5. |t WNT Inhibitors and their Potential Utility in Liquid Tumors -- |g 6. |t WNT and Immunooncology -- |g 7. |t Looking Ahead -- |t Acknowledgments -- |t References -- |g 9. |t Wnt Signaling Landscape of Mammary Stem Cells and Breast Tumors / |r Caroline M. Alexander -- |g 1. |t Introduction -- |g 2. |t Wnt Landscape of Mammary Epithelial Cells -- |g 3. |t Wnt Signaling and Mammary Stem Cells -- |g 4. |t Wnt Signaling in Breast Cancer -- |g 5. |t Conclusions -- |t Acknowledgments -- |t References -- |g 10. |t Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy / |r Toby J. Phesse -- |g 1. |t Introduction -- |g 2. |t Wnt Signaling Pathway -- |g 3. |t Organoids Derived from Adult Epithelium -- |g 4. |t Organoids Derived from Patient Tumors -- |g 5. |t Modeling Dormant Tumor Cells: The Next Frontier for Tumor Organoids -- |g 6. |t Conclusions -- |t Acknowledgments -- |t References -- |g 11. |t Wnt Signaling in Hematological Malignancies / |r Karl Willert -- |g 1. |t Hematopoietic Stem Cell (HSC) Development -- |g 2. |t HSC Homeostasis -- |g 3. |t Wnt Signaling -- |g 4. |t Wnt in HSC Development and Homeostasis -- |g 5. |t Wnt Signaling in Leukemia -- |g 6. |t Wnt Signaling in Lymphoma -- |g 7. |t Wnt Signaling in Myeloma -- |g 8. |t Conclusions and Perspectives -- |t References. |
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