Chemical and biochemical approaches for the study of anesthetic function. Part B /
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| Edition: | First edition. |
|---|---|
| Imprint: | Cambridge, MA : Academic Press, an imprint of Elsevier, 2018. |
| Description: | 1 online resource |
| Language: | English |
| Series: | Methods in enzymology ; volume 603 Methods in enzymology ; v. 603. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12379108 |
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| 245 | 0 | 0 | |a Chemical and biochemical approaches for the study of anesthetic function. |p Part B / |c edited by Roderic G. Eckenhoff, Ivan J. Dmochowski. |
| 250 | |a First edition. | ||
| 264 | 1 | |a Cambridge, MA : |b Academic Press, an imprint of Elsevier, |c 2018. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent |0 http://id.loc.gov/vocabulary/contentTypes/txt | ||
| 337 | |a computer |b c |2 rdamedia |0 http://id.loc.gov/vocabulary/mediaTypes/c | ||
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| 490 | 1 | |a Methods in enzymology ; |v volume 603 | |
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed April 24, 2018). | |
| 504 | |a Includes bibliographical references. | ||
| 505 | 0 | |a Intro; Title page; Table of Contents; Copyright; Contributors; Preface; Section I: Structural Approaches; Chapter One: Structural Analysis of Anesthetics in Complex with Soluble Proteins; Abstract; 1 Introduction; 2 Crystallographic Issues Relevant to Analysis of Anesthetic Binding; 3 Crystallizing Apoferritin with Isoflurane and Propofol; 4 Protocol; 5 Analysis of the Structure; 6 Summary; Acknowledgment; Chapter Two: X-Ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels; Abstract; 1 Introduction. | |
| 505 | 8 | |a 2 Production of Monodisperse pLGICs with High Purity3 Crystallization of pLGICs in the Absence and Presence of General Anesthetics; 4 Functional Validation of the Bound Anesthetics; 5 Case Studies; Acknowledgments; Chapter Three: Solution NMR Studies of Anesthetic Interactions with Ion Channels; Abstract; 1 Introduction; 2 Preparation of Ion Channels for Solution NMR; 3 NMR Methods to Identify Anesthetics Binding Sites and Detect Anesthetic-Induced Dynamics Changes; 4 Case Studies; Acknowledgments. | |
| 505 | 8 | |a Chapter Four: Time-Resolved Neutron Interferometry and the Mechanism of Electromechanical Coupling in Voltage-Gated Ion ChannelsAbstract; 1 Introduction; 2 Methods; 3 Results; 4 Discussion; 5 Conclusions and Future Prospects; Acknowledgments; Section II: Evolving Biophysical Technologies; Chapter Five: Fluorescent Anesthetics; Abstract; 1 Introduction; 2 Value of 1-AMA for Studying General Anesthetic Mechanisms; 3 Value of 1-AZA for Studying General Anesthetic Mechanisms; 4 Experiments; Chapter Six: Investigation of Anesthetic-Protein Interactions by a Thermodynamic Approach; Abstract. | |
| 505 | 8 | |a 1 Introduction2 ITC Measurements; 3 Conclusion; Chapter Seven: Electron Spin Resonance (EPR) in Drosophila and General Anesthesia; Abstract; 1 Introduction; 2 Electron Spin Resonance Primer; 3 Quantitation; 4 Sample Preparation; 5 Measurements; 6 Origin of the Spin Signal in Drosophila; 7 Conclusions; Chapter Eight: Giant Plasma Membrane Vesicles: An Experimental Tool for Probing the Effects of Drugs and Other Conditions on Membrane Domain Stability; Abstract; 1 Introduction; 2 GPMV Formation; 3 Measuring GPMV Miscibility Transition Temperatures; 4 Summary and Conclusion; Acknowledgments. | |
| 505 | 8 | |a Section III: In vivo Technologies Established and Evolving; Chapter Nine: Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs; Abstract; 1 Introduction; 2 Etomidate Analog Design Strategies; 3 Testing Novel Etomidate Analogs for Hypnotic Activity Using Loss of Righting Reflexes Assays; 4 Testing Novel Etomidate Analogs for Adrenocortical Inhibitory Activity; 5 Summary and Conclusion; Acknowledgments; Chapter Ten: Optoanesthesia: Use of Anesthetic Photolabels In Vivo; Abstract; 1 Introduction; 2 Anesthetic Photolabel Availability. | |
| 650 | 0 | |a Anesthetics |x Mechanism of action. | |
| 650 | 0 | |a Anesthetics |x Physiological effect. |0 http://id.loc.gov/authorities/subjects/sh85004979 | |
| 650 | 7 | |a MEDICAL |x Surgery |x General. |2 bisacsh | |
| 650 | 7 | |a Anesthetics |x Mechanism of action. |2 fast |0 (OCoLC)fst00808705 | |
| 650 | 7 | |a Anesthetics |x Physiological effect. |2 fast |0 (OCoLC)fst00808707 | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Eckenhoff, Roderic G., |e editor. |0 http://id.loc.gov/authorities/names/no2018073243 |1 http://viaf.org/viaf/291833427 | |
| 700 | 1 | |a Dmochowski, Ivan J., |e editor. |0 http://id.loc.gov/authorities/names/no2018073302 |1 http://viaf.org/viaf/862152636136120050423 | |
| 776 | 0 | 8 | |i Print version: |t Chemical and biochemical approaches for the study of anesthetic function. Part B. |b First edition. |d Cambridge, MA : Academic Press, an imprint of Elsevier, 2018 |z 0128145749 |z 9780128145746 |w (OCoLC)1007038716 |
| 830 | 0 | |a Methods in enzymology ; |v v. 603. |0 http://id.loc.gov/authorities/names/n42016419 | |
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