GABAb receptor pharmacology : a tribute to Norman Bowery /
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| Edition: | 1st ed. |
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| Imprint: | Amsterdam ; Boston : Elsevier, 2010. |
| Description: | 1 online resource (521 pages) |
| Language: | English |
| Series: | Advances in pharmacology, 1054-3589 |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12379738 |
| Related Items: | Main series:
Advances in pharmacology |
| Summary: | <p>This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptorin the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse. <p>The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular. <br>Articles written by leading investigators in the fieldInforms and updates on all the latest developments" |
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| Item Description: | V. GAT1 Activity and GABABR Activation |
| Physical Description: | 1 online resource (521 pages) |
| Bibliography: | ReferencesGABAB Receptor Coupling to G-proteins and Ion Channels; Abstract; I. Introduction; II. GABAB Receptor Structure; III. GABAB Receptor Protein Expression; Iv. GABAB Receptor Effectors; V. Formation of a Macromolecular Signaling Heterocomplex; VI. GABAB Receptor-Dependent Desensitization; VII. Conclusion; Abbreviations; References; GABAB Receptor-Mediated Modulation of Metabotropic Glutamate Signaling and Synaptic Plasticity in Central Neurons; Abstract; I. Introduction; II. Synaptic Organization Around Cerebellar Purkinje Cells Includes bibliographical references and index. |
| ISBN: | 1282770039 9781282770034 9786612770036 6612770031 0123786487 9780123786487 9780123786470 |
| ISSN: | 1054-3589 |