Hiv-1 Envelope Glycoproteins : Folding, Function and Vaccin Design.
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| Author / Creator: | Sanderson, Ian, author. |
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| Imprint: | Leiden University Press [Imprint] March 2004 Amsterdam : Amsterdam University Press. |
| Description: | 1 online resource. |
| Language: | English |
| Series: | UvA Proefschriften Ser. UvA Proefschriften Ser. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12449954 |
| Summary: | The need for a vaccine against HIV is obvious, but the development of an effective vaccine has met with frustrations. The HIV envelope glycoproteins, residing in the viral membrane, are the sole viral proteins exposed on the outside of virus particles and are therefore major targets for vaccine design. The first part of this thesis describes research aimed at understanding the folding and function of the HIV-1 envelope glycoproteins and their properties underlying the effective viral immune evasion. The second part of the thesis describes the design of modifications of the envelope glycoproteins that should improve their properties as vaccine antigens. |
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| Physical Description: | 1 online resource. |
| ISBN: | 9789053566671 9053566678 |