Handbook of the biology of aging.
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| Edition: | Ninth edition / edited by Nicolas Musi, Peter Hornsby. |
|---|---|
| Imprint: | Amsterdam : Academic Press, 2021. |
| Description: | 1 online resource. |
| Language: | English |
| Series: | The handbooks of aging Handbooks of aging. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12519289 |
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| 245 | 0 | 0 | |a Handbook of the biology of aging. |
| 246 | 3 | 0 | |a Biology of aging |
| 250 | |a Ninth edition / |b edited by Nicolas Musi, Peter Hornsby. | ||
| 264 | 1 | |a Amsterdam : |b Academic Press, |c 2021. | |
| 300 | |a 1 online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a The handbooks of aging | |
| 505 | 0 | |a Front Cover -- Handbook of the Biology of Aging -- Copyright Page -- Dedication -- References -- Contents -- List of contributors -- About the editors -- Foreword -- Preface -- I. Basic mechanisms, underlying physiological changes, model organisms and interventions -- 1 Longevity as a complex genetic trait -- Introduction -- Defining the aging gene-space -- Direct screens for genetic longevity determinants -- RNA interference screens in nematodes -- Knockout screens in budding yeast -- Overexpression and knockout screens in fruit flies -- Leveraging genetic diversity to identify aging loci | |
| 505 | 8 | |a Mapping longevity genes in human populations -- Mapping longevity genes in mouse populations -- Mouse-human concordance -- Age-associated gene expression studies -- Nongenetic sources of complexity -- Tissue-specific aging -- Tissue-specific age-related DNA methylation -- Tissue-specific responses of aging pathways -- Gene-environment interaction -- Genetic response to dietary restriction -- Dietary restriction: quantity, composition, and timing -- Other environmental factors that influence aging -- Emerging tools for studying complex genetic traits | |
| 505 | 8 | |a High-throughput life span assays in yeast and worms -- Genome-scale mouse knockout collection -- Collaborative cross and diversity outbred mice -- Expression QTLs -- Aging biomarkers -- Conclusions -- References -- 2 DNA damage and repair in aging -- Introduction -- Overview of the DNA damage response -- Endogenous DNA damage -- DNA damage induced by environmental exposures -- Linkage of DNA repair mechanisms to aging -- Nucleotide excision repair -- Base excision repair -- DNA double-strand break repair -- DNA damage theory of aging -- Aging disorders associated with DNA damage | |
| 505 | 8 | |a Diseases stemming from mutations in RecQ helicases -- Werner syndrome -- RECQL4 and premature aging syndromes -- Progeroid and other disorders associated with defects in nucleotide excision repair -- Xeroderma pigmentosum -- Cockayne syndrome -- Trichothiodystrophy -- XFE progeroid syndrome -- MDPL syndrome -- Ruijs-Aalfs syndrome -- Conclusions and future perspectives -- Acknowledgments -- References -- 3 Mechanisms of cell senescence in aging -- What is senescence? Building blocks and feedback loops -- The building blocks of the senescent phenotype -- Telomeres and the DNA damage response | |
| 505 | 8 | |a Senescence-associated secretory phenotype -- Senescence-associated mitochondrial dysfunction -- Nutrient signaling -- Autophagy/mitophagy -- Epigenetic reprogramming -- Terminology -- Replicative versus stress-induced senescence -- Senescence-associated secretory phenotype -- Senescence during aging in vivo -- Senescence in postmitotic cells -- Senescent cell bystander effects -- Senolytics and senostatics as antiaging interventions -- Senolytics -- Senostatics -- Conclusions -- References -- 4 The nature of aging and the geroscience hypothesis -- Aging and the geroscience hypothesis | |
| 650 | 0 | |a Aging |x Physiological aspects. | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Musi, Nicolas, |e editor. | |
| 700 | 1 | |a Hornsby, Peter, |e editor. | |
| 776 | 0 | 8 | |i ebook version : |z 9780128162835 |
| 776 | 0 | 8 | |c Original |z 9780128159620 |z 0128159626 |w (OCoLC)1222776311 |
| 830 | 0 | |a Handbooks of aging. |0 http://id.loc.gov/authorities/names/n84744657 | |
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| 928 | |t Library of Congress classification |a QP86 |l Online |c UC-FullText |u https://www.sciencedirect.com/science/book/9780128159620 |z Elsevier |g ebooks |i 12168484 | ||