Nonviral vectors for gene therapy lipid- and polymer-based gene transfer /
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| Imprint: | Amsterdam : Elsevier/Academic Press, 2014. |
|---|---|
| Description: | 1 online resource (xiii, 409 pages) : illustrations (some colour). |
| Language: | English |
| Series: | Advances in genetics ; v. 88 Advances in genetics ; v. 88. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12588229 |
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| 245 | 0 | 0 | |a Nonviral vectors for gene therapy lipid- and polymer-based gene transfer / |c edited by Leaf Huang, Dexi Liu and Ernst Wagner. |
| 264 | 1 | |a Amsterdam : |b Elsevier/Academic Press, |c 2014. | |
| 300 | |a 1 online resource (xiii, 409 pages) : |b illustrations (some colour). | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Advances in genetics ; |v v. 88 | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover; Advances in Genetics Nonviral Vectors for Gene Therapy; Copyright; DEDICATION; CONTENTS; CONTRIBUTORS; Chapter 1 -- Nonviral Vectors: We Have Come a Long Way; 1. INTRODUCTION; 2. CHEMICAL METHODS; 3. PHYSICAL METHODS; 4. PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; Chapter 2 -- Lipid Nanoparticles for Gene Delivery; 1. INTRODUCTION; 2. RATIONAL DESIGNS TO OVERCOME EXTRACELLULAR AND INTRACELLULAR BARRIERS; 3. CURRENT LIPIDIC VECTORS FOR GENE DELIVERY; 4. GENE THERAPY APPLICATIONS; 5. PHARMACOKINETICS, BIODISTRIBUTION AND TOXICITY OF LNPS; 6. CLINICAL TRIALS; 7. CONCLUSIONS. | |
| 505 | 8 | |a ACKNOWLEDGMENTSREFERENCES; Chapter 3 -- Nanotechnology for In vivo Targeted siRNA Delivery; 1. RNA POTENTLY MODIFIES GENE EXPRESSION; 2. TARGETING STRATEGIES; 3. TARGETING THE LIVER; 4. TARGETING PRIMARY TUMORS AND METASTASIS; 5. ENDOTHELIAL CELL TARGETING; 6. FUTURE PERSPECTIVES; REFERENCES; Chapter 4 -- Lipid Nanoparticles for Short Interfering RNA Delivery; 1. INTRODUCTION; 2. CHALLENGES AND STRATEGIES FOR DELIVERY OF SIRNA; 3. LIPID-BASED DELIVERY SYSTEMS; 4. LNP-SIRNA FORMULATIONS IN CLINICAL TRIALS; 5. FUTURE PROSPECTS; REFERENCES; Chapter 5 -- Composite Nanoparticles for Gene Delivery. | |
| 505 | 8 | |a 1. NANOMEDICINE AND GENE THERAPY2. COMPOSITE NANOPARTICLES; 3. FABRICATION METHODS OF COMPOSITE NANOPARTICLES; 4. COMPOSITE NANOPARTICLES FOR TARGETED GENE DELIVERY; 5. CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 6 -- Multifunctional Enveloped Nanodevices (MENDs); 1. INTRODUCTION; 2. R8-MEND; 3. KALA-MEND; 4. MITO-PORTER; 5. YSK-MEND; 6. SS-CLEAVABLE PROTON-ACTIVATED LIPID-LIKE MATERIAL (SSPALM); 7. PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; Chapter 7 -- Lipid-Coated Calcium Phosphate Nanoparticles for Nonviral Gene Therapy. | |
| 505 | 8 | |a 1. RECENT PROGRESS OF NONVIRAL GENE THERAPY AND IN VITRO/IN VIVO DELIVERY SYSTEMS2. LCP NANOPARTICLES AS A MULTIFUNCTIONAL PLATFORM FOR GENE DELIVERY; 3. POTENTIAL THERAPEUTIC APPLICATIONS OF LCP: CANCER, CHRONIC LIVER DISEASE, AND GENE THERAPY; 4. LCP NANOPARTICLES: CONCLUSIONS; REFERENCES; Chapter 8 -- Polymers for Nucleic Acid Transfer-An Overview; 1. FIVE DECADES IN POLYPLEXES: CHALLENGES AND BREAKTHROUGHS; 2. OPTIMIZING THE CORE: BIODEGRADABLE AND BIOCOMPATIBLE POLYMERS; 3. OPTIMIZING THE SHELL: BIOINSPIRED SMART POLYPLEXES; 4. NEXT STEPS: MULTIFUNCTIONAL AND SEQUENCE-DEFINED POLYMERS. | |
| 505 | 8 | |a 5. PERSPECTIVESREFERENCES; Chapter 9 -- Recent Developments in Nucleic Acid Delivery with Polyethylenimines; 1. INTRODUCTION; 2. MECHANISM OF PEI-MEDIATED DNA TRANSFECTION; 3. PROTON SPONGE: MYTH OR REALITY?; 4. PEI FOR GENE DELIVERY; 5. PEI DERIVATIVES FOR THE DELIVERY OF EXON SKIPPING OLIGONUCLEOTIDES; 6. PEIS FOR SIRNA DELIVERY; 7. CONCLUSION; REFERENCES; Chapter 10 -- Bioresponsive Polymer-Based Nucleic Acid Carriers; 1. INTRODUCTION; 2. POLYMER SELF-ASSEMBLIES FOR NUCLEIC ACID DELIVERY; 3. REDUCTIVE ENVIRONMENT-RESPONSIVE NUCLEIC ACID DELIVERY. | |
| 520 | |a The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. <i>Advances in Genetics</i> continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. <br><br><ul><li>Includes methods for testing with ethical, legal, and social implications</li><li>Critically analyzes future directions</li><li>Written and edited by recognized leaders in the field</li></ul> | ||
| 650 | 0 | |a Genetic vectors. |0 http://id.loc.gov/authorities/subjects/sh85053875 | |
| 650 | 0 | |a Gene therapy. |0 http://id.loc.gov/authorities/subjects/sh85053738 | |
| 650 | 7 | |a Gene therapy. |2 fast |0 (OCoLC)fst00939638 | |
| 650 | 7 | |a Genetic vectors. |2 fast |0 (OCoLC)fst00940107 | |
| 650 | 7 | |a SCIENCE |x Chemistry |x Industrial & Technical. |2 bisacsh | |
| 650 | 7 | |a TECHNOLOGY & ENGINEERING |x Chemical & Biochemical. |2 bisacsh | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Huang, Leaf, |e editor. |0 http://id.loc.gov/authorities/names/nb99048144 | |
| 700 | 1 | |a Liu, Dexi, |e editor. |0 http://id.loc.gov/authorities/names/nr95037479 | |
| 700 | 1 | |a Wagner, Ernst, |d 1960- |e editor. |0 http://id.loc.gov/authorities/names/nb91094891 | |
| 830 | 0 | |a Advances in genetics ; |v v. 88. |0 http://id.loc.gov/authorities/names/no98109310 | |
| 903 | |a HeVa | ||
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| 928 | |t Library of Congress classification |a QH442.2 |l Online |c UC-FullText |u https://www.sciencedirect.com/science/bookseries/00652660/88 |z Elsevier |g ebooks |i 12579723 | ||