Cullin-RING ligases and protein neddylation : biology and therapeutics /
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Imprint: | Singapore : Springer, 2020. |
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Description: | 1 online resource (372 pages) |
Language: | English |
Series: | Advances in Experimental Medicine and Biology ; v. 1217 Advances in experimental medicine and biology ; v. 1217. |
Subject: | |
Format: | E-Resource Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12603093 |
Table of Contents:
- Chapter 1 Introduction of Protein Ubiquitination and Cullin/RING Ubiquitin Ligases: introduce the protein ubiquitination system briefly; discuss the family of Cullin/RING Ubiquitin Ligases
- Chapter 2 Assembly and Regulation of CRL ubiquitin ligases: discuss the assembly process of CRL ubiquitin ligases by CAND1; elaborate the regulation of CRL ubiquitin ligases by neddylation
- Chapter 3 Protein structure of CRL and Neddylation complex
- Chapter 4 The roles of CRL ubiquitin ligases and neddylation in human diseases
- Chapter 5 The roles of CRL ubiquitin ligases in stem cell biology: Briefly introduce concept and potential application of stem cells; analyze a few example for CRL ubiquitin ligases to control stem cell biology
- Chapter 6 The biology of F-box proteins: introduce the history of SCF ubiquitin ligases; discuss the overall functions of F-box proteins (emphasize phospho-degron concept)
- Chapter 7 The roles of Fbxw7 in human diseases: discuss the roles of Fbw7 in cancer; elaborate the roles of Fbxw7 in other diseases
- Chapter 8 Mouse models of CRL1 components to study their biological function
- Chapter 9 Cullin2 and cancer: introduce Cullin2 ubiquitin ligases; discuss VHL ubiquitin ligase and its roles in cancer
- Chapter 10 Cullin3 and tumorigenesis: introduce Cullin3 ubiquitin ligases; discuss a few examples of Cullin3 ubiquitin ligases in control of tumorigenesis
- Chapter 11 Cullin4-DCAF proteins in tumorigenesis: Discovery of DCAF proteins; discuss a few examples of DCAF's biological functions
- Chapter 12 Cullin4 ubiquitin ligases in DNA damage responses: Introduce Cullin4 ubiquitin ligases; discuss the roles of Cullin4 ubiquitin ligases in DNA damage responses
- Chapter 13 Coordinating the roles of Cullin5 ubiquitin ligases by SAG and UBE2F: introduce Cullin5 ubiquitin ligases; discuss how SGA and UBE2F mediates the functions of Cullin5
- Chapter 14 Cullin5 in anti-virus infection: mechanism and drug target
- Chapter 15 The roles of Cul7 in cancer biology: introduce Cullin7 ubiquitin ligase7; discuss a few examples of Cullin7 ubiquitin ligases in cancer
- Chapter 16 Coordinating functions of p97 and CRL ubiquitin ligases in protein turnover: introduce the interactions between p97 and CRL ubiquitin ligases; discuss the coordinating roles between p97 and CRL ubiquitin ligases in protein turnover
- Chapter 17 Interaction between CRL ubiquitin ligases and COP9 Signalosome: introduce Cop9 signalosome; discuss how Cop9 signalosome regulates CRL ubiquitin ligases
- Chapter 18 Drug discovery effort to target Cullin-3 neddylation: discuss inhibitor of Cullin3 neddylation and its application
- Chapter 19 Targeting neddylation modification: Briefly introduce protein neddylation; discuss the roles of neddylation in cancer
- Chapter 20 Targeting CRL ubiquitin ligases: discuss current progress in targeting CRL ubiquitin ligases; discuss the application of CRL ubiquitin ligases in Protac drug development.