Proteostasis and disease : from basic mechanisms to clinics /
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| Imprint: | Cham : Springer, [2020] |
|---|---|
| Description: | 1 online resource (350 p.) |
| Language: | English |
| Series: | Advances in experimental medicine and biology ; v.1233 Advances in experimental medicine and biology ; v. 1233. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12604924 |
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| 245 | 0 | 0 | |a Proteostasis and disease : |b from basic mechanisms to clinics / |c Rosa Barrio, James D. Sutherland, Manuel S. Rodriguez, editors. |
| 260 | |a Cham : |b Springer, |c [2020] | ||
| 300 | |a 1 online resource (350 p.) | ||
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| 490 | 1 | |a Advances in experimental medicine and biology ; |v v.1233 | |
| 500 | |a Description based upon print version of record. | ||
| 505 | 0 | |a Intro -- Preface -- Acknowledgments -- Contents -- Part I: Cancer -- Chapter 1: Ubiquitin-Regulated Cell Proliferation and Cancer -- 1.1 Introduction to Cell Cycle Regulation -- 1.1.1 Regulation of CDK-Cyclin Activity by the UPS -- 1.1.2 SCF in Cell Cycle Control -- 1.1.3 SCF in DNA Damage -- 1.1.4 APC/C and the Regulation of Mitosis -- 1.2 Non-proteolytic Protein Ubiquitination in the Control of Cell Cycle Progression -- 1.2.1 Cell Signaling and Non-proteolytic Protein Ubiquitination in G1 -- 1.2.2 Non-proteolytic Protein Ubiquitination During G1/S to G2 Transition | |
| 505 | 8 | |a 2.4.1.1 Ubiquitin E1 Inhibitors -- 2.4.1.2 Nedd8 E1 Inhibitors -- 2.4.1.3 SUMO E1 Inhibitors -- 2.4.2 E2 Inhibitors -- 2.4.3 E3 Inhibitors -- 2.4.3.1 MDM2 Inhibitors -- 2.4.3.2 IAP Inhibitors -- 2.5 Conclusion -- References -- Chapter 3: The Proteasome System in Health and Disease -- 3.1 Introduction -- 3.2 20S Proteasomes: Structure and Regulation -- 3.2.1 Alternative Composition of the 20S Proteasome -- 3.2.2 Expression and Assembly of the 20S Proteasome -- 3.2.3 Activation of the 20S Proteasome -- 3.2.4 Posttranslational Modifications (PTMs) -- 3.2.5 Localization --3.4 Proteasomes in Diseased States. | |
| 520 | |a This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field. | ||
| 650 | 0 | |a Proteomics. |0 http://id.loc.gov/authorities/subjects/sh2002000814 | |
| 650 | 0 | |a Proteins |x Metabolism. |0 http://id.loc.gov/authorities/subjects/sh85107672 | |
| 650 | 0 | |a Ubiquitin. |0 http://id.loc.gov/authorities/subjects/sh88001325 | |
| 650 | 0 | |a Diseases |x Molecular aspects. | |
| 650 | 2 | |a Proteasome Endopeptidase Complex. |0 (DNLM)D046988 | |
| 650 | 2 | |a Proteostasis. |0 (DNLM)D000074702 | |
| 650 | 2 | |a Ubiquitin-Protein Ligases. |0 (DNLM)D044767 | |
| 650 | 7 | |a Ubiquitin. |2 fast |0 (OCoLC)fst01160282 | |
| 650 | 7 | |a Proteomics. |2 fast |0 (OCoLC)fst01079785 | |
| 650 | 7 | |a Proteins |x Metabolism. |2 fast |0 (OCoLC)fst01079741 | |
| 650 | 7 | |a Proteins. |2 fast |0 (OCoLC)fst01079711 | |
| 655 | 0 | |a Electronic books. | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Barrio, Rosa. | |
| 700 | 1 | |a Rodriguez, Manuel S. |0 http://id.loc.gov/authorities/names/nb2016020119 | |
| 700 | 1 | |a Sutherland, James D. | |
| 776 | 0 | 8 | |i Print version: |a Barrio, Rosa |t Proteostasis and Disease : From Basic Mechanisms to Clinics |d Cham : Springer,c2020 |z 9783030382650 |
| 830 | 0 | |a Advances in experimental medicine and biology ; |v v. 1233. |0 http://id.loc.gov/authorities/names/n42001229 | |
| 880 | 8 | |6 505-00/(S |a 3.3 Proteasome Regulators: Structure and Regulation -- 3.3.1 19S Regulator and Controlled Assembly of 26S Proteasomes -- 3.3.1.1 Subcellular Localization of 26S Proteasomes -- 3.3.1.2 Regulating Abundance of 26S Proteasomes -- 3.3.1.3 Assembly and Disassembly of 26S Proteasomes -- 3.3.1.4 Fine-Tuning Activity of 26S Proteasomes by Posttranslational Modifications -- 3.3.1.5 Regulation of 26S Proteasome by (Transiently) Associated Proteins -- ECM29 -- Ub-Ligases, DUBs Associated to the 26S Proteasome -- 3.3.2 PA28/REG -- 3.3.2.1 PA28αβ -- 3.3.2.2 PA28γ -- 3.3.3 PA200 -- 3.3.4 PI31 | |
| 880 | 8 | |6 505-00/(S |a 1.2.3 Non-proteolytic Ubiquitination in Mitosis -- 1.3 Deregulation of Ubiquitin-Mediated Proteolysis in Cancer -- 1.3.1 pRb Degradation and Cancer -- 1.3.2 SCFβ-TrCP, Mdm2, and DNA Damage -- 1.3.3 SCFβ-TrCP and Colorectal Cancer -- 1.3.4 SCFSkp2, Cell Cycle Progression, and Cancer -- 1.3.5 SCFFBXW7 and Cancer -- 1.3.6 SCFFBXW7, MCL-1, and Apoptosis -- 1.3.7 APC/C in Cancer -- 1.4 Targeted Therapy of the Ubiquitin-Proteasome System in Cancer -- References -- Chapter 2: Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer -- 2.1 Introduction | |
| 880 | 8 | |6 505-00/(S |a 2.2 Oncogenic and Tumor Suppressor Pathways Are Controlled by UbLs -- 2.2.1 The p53 Pathway -- 2.2.2 The NF-κB Pathway -- 2.2.3 The TGF-β Pathway -- 2.2.4 PML-RARα in Acute Promyelocytic Leukemias -- 2.3 Deregulations of UbL Pathways in Cancer -- 2.3.1 Many UbL Enzymes Are Dysregulated in Cancers -- 2.3.2 Dysregulation of the Ubiquitin Pathway Enzyme in Cancer -- 2.3.3 Overactivation of the Nedd8 Pathway in Cancer Is Often Associated with Bad Prognosis -- 2.3.4 Dysregulations of the SUMO Pathway in Cancer -- 2.4 Targeting UbLs: New Perspectives in Cancer Treatment -- 2.4.1 E1 Inhibitors | |
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