Reviews on new drug targets in age-related disorders /

Reviews on new drug targets in age-related disorders /

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Bibliographic Details
Imprint:Cham : Springer, 2020.
Description:1 online resource (343 p.).
Language:English
Series:Advances in experimental medicine and biology, oteomics, metabolomics, interactomics and systems biology
Advances in experimental medicine and biology. Proteomics, metabolomics, interactomics and systems biology.
Subject:
Drug targeting.
Biochemistry.
Drug Delivery Systems.
Aged.
Humans.
Drug targeting.
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/12605028
Hidden Bibliographic Details
Other authors / contributors:Guest, Paul C.
ISBN:9783030426675
303042667X
9783030426668
3030426661
Notes:Description based upon print version of record.
6.1 Sarcopenia and Costs Associated with Hospitalization
Includes index.
Summary:Aging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies.
Other form:Print version: Guest, Paul C. Reviews on New Drug Targets in Age-Related Disorders Cham : Springer International Publishing AG,c2020 9783030426668
Standard no.:10.1007/978-3-030-42
Table of Contents:
  • Intro
  • Preface
  • Contents
  • Chapter 1: Targeting ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Cancer
  • 1 Introduction
  • 2 The Function of ROS in Cancer Development and Treatment
  • 3 ROS-Mediated Cancer Cell Autophagy
  • 4 ROS-Mediated Cancer Cell Apoptosis
  • 5 ROS-Mediated Complex Interplay Between Autophagy and Apoptosis in Cancer Cells
  • 6 Conclusions
  • References
  • Chapter 2: Micronutrients that Affect Immunosenescence
  • 1 Introduction
  • 2 The Immune System in Aging
  • 3 Intake of Micronutrients in the Elderly
  • 9 Cancer and Auto-immune Diseases Are Two Sides of the Same Coin
  • 10 Ion Channels and Bioactive Lipids
  • 11 Connecting the Cell Membrane to the Nucleus
  • 12 Polyunsaturated Fatty Acids and Bioactive Lipids Are Involved in Mitochondrial Processes
  • 13 Bioactive Lipids Modulate G-Protein-Mediated Signals
  • 14 Age-Related Disorders Are Inflammatory Conditions and Can Be Modulated by Bioactive Lipids
  • 15 Conclusions and Future Perspectives
  • References
  • Chapter 4: Effect of Short Chain Fatty Acids on Age-Related Disorders
  • 1 Introduction
  • 2 SCFAs and Metabolic Diseases
  • 3 SCFAs and Hypertension and CVDs
  • 4 SCFAs and Neurodegenerative Disease
  • 5 SCFAs and Cancer
  • 6 Conclusions
  • References
  • Chapter 5: The Effects of Parabiosis on Aging and Age-Related Diseases
  • 1 Introduction
  • 2 Organ and Tissue Rejuvenation via Heterochronic Parabiosis
  • 2.1 Liver
  • 2.2 Skeletal Muscle
  • 2.3 Nervous System
  • 2.4 Endocrine Pancreas
  • 2.5 Heart
  • 2.6 Bone
  • 3 Looking for a "Silver Bullet"
  • 3.1 GDF11: A Controversial Hero
  • 3.2 Other Contenders
  • 4 Conclusions
  • References
  • Chapter 6: Skeletal Muscle Aging Atrophy: Assessment and Exercise-Based Treatment
  • 1 Introduction
  • 2 Skeletal Muscle Aging Atrophy
  • 3 Basic and Instrumental Activities of Daily Living Assessment
  • 3.1 Barthel Index
  • 3.2 Katz Index
  • 3.3 Lawton and Brody Scale
  • 4 Physical Performance Assessment
  • 4.1 Grip Strength Test
  • 4.2 Gait Speed Test
  • 4.3 Timed Up and Go Test
  • 4.4 Unipedal Stance Test
  • 4.5 Tinetti Scale
  • 4.6 Short Physical Performance Battery
  • 4.7 Senior Fitness Test
  • 5 Cognitive Assessment
  • 5.1 Mini Mental State Examination
  • 5.2 Pfeffer Scale
  • 5.3 Geriatric Depression Scale
  • 6 Skeletal Muscle Atrophy: Aging and Hospitalization Combined

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