Immunotherapy /

Immunotherapy /

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Bibliographic Details
Edition:3rd ed.
Imprint:Cham : Springer, 2020.
Description:1 online resource (342 p.).
Language:English
Series:Advances in Experimental Medicine and Biology ; v.1244
Advances in experimental medicine and biology ; v. 1244.
Subject:
Immunotherapy.
Immunotherapy.
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/12605051
Hidden Bibliographic Details
Other authors / contributors:Naing, Aung.
Hajjar, Joud.
ISBN:9783030410087
3030410080
9783030410070
Digital file characteristics:text file PDF
Notes:Description based upon print version of record.
Anal Cancer
Summary:Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book's chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.
Other form:Print version: Naing, Aung Immunotherapy Cham : Springer International Publishing AG,c2020 9783030410070
Standard no.:10.1007/978-3-030-41008-7
Table of Contents:
  • Intro
  • Contents
  • Contributors
  • 1: Overview of Basic Immunology and Clinical Application
  • Innate Immune System
  • Cellular Components of the Innate Immune System
  • Leukocytes
  • Neutrophils
  • Monocytes and Macrophages
  • Eosinophils
  • Basophils
  • Mast Cells
  • Dendritic Cells
  • Natural Killer Cells
  • Adaptive Immune System
  • Cellular Components of the Adaptive Immune System
  • T Lymphocytes
  • B Lymphocytes
  • Immunoglobulins
  • The Immune System in Action!
  • Summary of the Immune Responses against Tumor Cells
  • Cancer Immunotherapy
  • Translational Relevance
  • PD-L1 Expression
  • Tumor-Infiltrating Lymphocytes
  • Immunoscore
  • T-Cell Receptor Diversity
  • Mutation Load and Molecular Alterations
  • Immune Gene Signature
  • Cancer Immunogram
  • Serum Biomarkers
  • Circulating Biomarkers
  • Microbiome Assessment
  • Conclusion
  • References
  • 2: Advances in Diagnostic Procedures and Their Applications in the Era of Cancer Immunotherapy
  • Introduction
  • Immunohistochemistry
  • IHC Applications
  • Cancer Pathology Diagnostics
  • Predictive Biomarker Tests
  • Single-Marker Versus Multiplexed IHC
  • Next-Generation Sequencing
  • Flow Cytometry
  • Other Preclinical and Clinical Diagnostics Techniques in Immunotherapy Research
  • Preclinical Tumor Models in Immunotherapy Research
  • Immunodeficient and Immunocompetent Mouse Models, Nude Mouse
  • Xenograft Tumor Models
  • Common Translational Research Techniques and their Biospecimen Requirements
  • References
  • 3: Immunotherapy for Melanoma
  • Introduction
  • Short Overview of the History of Melanoma Treatment Options up to 2011
  • High-Dose Interleukin-2
  • Chemotherapy
  • Adoptive Cell Therapy (ACT)
  • Immune Checkpoint Inhibitors
  • Anti-CTLA-4: Ipilimumab
  • Anti-PD-1
  • Nivolumab
  • Pembrolizumab
  • Ipilimumab and Nivolumab in Combination
  • Ipilimumab and Pembrolizumab in Combination
  • Anti-PD-L1
  • Vaccination and Intratumoral Approaches
  • PV-10 (Rose Bengal)
  • T-VEC
  • Brain Metastases and Immunotherapy
  • Adjuvant Therapies
  • Adjuvant Therapy with Interferon
  • Adjuvant Biochemotherapy
  • CPIs in the Adjuvant Setting
  • The Future of Melanoma Treatment
  • Indoleamine Dioxygenase (IDO) Inhibitors
  • Lymphocyte-Activation Gene 3 (LAG-3)
  • T-Cell Immunoglobulin-3 (Tim-3)
  • OX40
  • 4-1BB
  • Toll-Like Receptors (TLRs)
  • Bempegaldesleukin (NKTR-214): A CD-122-Biased IL-2 Receptor
  • Melanoma Immunotherapy and the Gut Microbiome
  • Conclusion
  • References
  • 4: Immunotherapy in Lung Cancer: From a Minor God to the Olympus
  • Introduction
  • Early-Stage NSCLC and Locally Advanced NSCLC
  • First Line Metastatic NSCLC
  • Pre-treated NSCLC
  • ICIs and SCLC
  • Conclusions and Future Perspectives
  • References
  • 5: Immunotherapy in Gastrointestinal Malignancies
  • Introduction
  • Gastroesophageal Cancer
  • Current Evidence
  • Future Strategies
  • Colorectal Cancer
  • Current Evidence
  • Future Strategies

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