Molecular mechanisms of retina pathology and ways of its correction /

Molecular mechanisms of retina pathology and ways of its correction /

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Bibliographic Details
Author / Creator:Trofimova, Svetlana.
Imprint:Cham : Springer, 2020.
Description:1 online resource
Language:English
Subject:
Retina -- Diseases -- Molecular aspects.
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/12606644
Hidden Bibliographic Details
ISBN:9783030501600
3030501604
3030501590
9783030501594
Notes:Includes bibliographical references.
Summary:This book discusses the pathology of the retina, and reviews current research on the use of cell replacement therapy and short peptides to restore functional activity in retinal neurons. As the book describes, pathologies of the retina, including age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, present a long-standing challenge in the practice of clinical ophthalmology. Modern treatment for these conditions, which lead to irreversible blindness, includes laser exposure, surgical intervention, and drugs. These treatments aim to reduce the risk of new complications in the eye; pathogenetic therapy of degenerative diseases of the retina is practically absent in current ophthalmic practice. The first section of the book reviews the molecular mechanisms of age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, and reports on methods of treatment. The second section presents the results of recent experimental studies of the effects of short peptides on pluripotent embryonic cells; on proliferative activity in retinal cells and pigment epithelium; on expression of markers of differentiation or retinal neurons and pigment epithelium; and on the course of hereditary retinal pigmentation in Campbell rats. The third section offers results of clinical studies on the effectiveness of short peptides in patients with macular degeneration, and in patients with retinitis pigmentosa. The author concludes that the regular use of peptides in the treatment of degenerative diseases of the retina can slow the progression of the pathological process and preserve the patients vision for some 10-15 years. In addition, in 80 percent of patients, it is possible to increase visual function by increasing visual acuity, improving the boundaries of the visual field and the fundus.
Other form:Original 3030501590 9783030501594
Standard no.:10.1007/978-3-030-50160-0
10.1007/978-3-030-50
Table of Contents:
  • Intro
  • Contents
  • Chapter 1: Literature Review
  • 1.1 Age-Related Characteristics of the Retina
  • 1.1.1 Molecular Mechanisms of Age-Related Macular Degeneration
  • 1.1.2 Molecular Mechanisms of Retinal Ischemia
  • 1.1.3 Molecular Mechanisms of Retinitis Pigmentosa
  • 1.1.4 Conclusion
  • 1.2 Current Trends in the Treatment of Retinal Diseases
  • 1.3 Results of Modern Scientific Research in the Field of Cell Replacement Therapy Using Neuronal Stem Cells
  • 1.4 Biological Effects of Peptide Bioregulators
  • References
  • Chapter 2: Results of Experimental Studies of Short Peptides (Cytogens) in Ophthalmology
  • 2.1 Results of a Study of the Induction Effects of Short Peptides on Pluripotent Embryonic Cells
  • 2.1.1 Methods of Morphological Assessment
  • 2.2 The Effect of Short Peptides on the Proliferative Activity of Retinal Cells and Pigment Epithelium
  • 2.2.1 Method of Preparation of Substrates for Cell Cultures
  • 2.2.2 Method of Obtaining Cell Cultures of the Retina and Pigment Epithelium of Rats
  • 2.2.3 Drug Administration
  • 2.2.4 Methods for Spectrophotometric Assessment of the Number of Living Cells in Suspension
  • 2.3 Effect of Short Peptides on Expression of Markers of Differentiation of Retinal Neurons and Pigment Epithelium
  • 2.4 Effect of Short Peptides on the Nature of the Course of Hereditary Retinal Pigment Degeneration in Campbell Rats
  • References
  • Chapter 3: Results of the Clinical Study of Short Peptides (Cytogens) in Ophthalmology
  • 3.1 Evaluation of the Effectiveness of Short Peptides (Cytogens) in Patients with Age-Related Macular Degeneration
  • 3.2 Evaluation of the Effectiveness of Short Peptides (Cytogens) in Patients with Retinitis Pigmentosa
  • 3.3 Conclusion
  • References
  • Conclusion
  • References

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