Recent advances in endometrial cancer /

Recent advances in endometrial cancer /

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Bibliographic Details
Imprint:Singapore : Springer, 2020.
Description:1 online resource (306 p.)
Language:English
Subject:
Endometrium -- Cancer -- Diagnosis.
Endometrium -- Cancer -- Treatment.
Endometrium -- Cancer -- Surgery.
Oncology.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/12606699
Hidden Bibliographic Details
Other authors / contributors:Mehta, Sumita.
Gupta, Bindiya.
ISBN:9789811553172
9811553173
9811553165
9789811553165
Notes:Description based upon print version of record.
3.7.2.6 Genistein
Summary:This book discusses in detail the recent advances in the management of endometrial cancer, including the latest therapies and diagnostic methods. The book focuses on treatment-oriented topics such as the role of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in endometrial cancer, and also explores treatment options in advanced disease stages, including hormonal therapy and targeted therapy. Providing insights into the evidence-based management guidelines for endometrial cancer, this book is a valuable resource for students, trainees and practitioners in the field of gynecology and gyne-oncology.
Other form:Print version: Mehta, Sumita Recent Advances in Endometrial Cancer Singapore : Springer Singapore Pte. Limited,c2020 9789811553165
Standard no.:10.1007/978-981-15-5317-2
10.1007/978-981-15-5
Table of Contents:
  • Intro
  • Preface
  • Contents
  • About the Editors
  • Contributors
  • Part I: Trends and Etiology of Endometrial Cancer
  • 1: Changing Trends in the Epidemiology of Endometrial Cancer
  • 1.1 Introduction
  • 1.2 Type I and II Carcinomas
  • 1.2.1 Pathophysiologic and Molecular Distinctions
  • 1.2.2 Type II-Specific Epidemiologic Factors
  • 1.3 Age
  • 1.4 Race/Ethnicity
  • 1.4.1 Blacks
  • 1.4.2 Hispanics
  • 1.4.3 Asians/Pacific Islanders
  • 1.4.4 American Indians/Alaska Natives
  • 1.4.5 Global Trends
  • 1.5 Endogenous Estrogen Exposure
  • 1.5.1 Pathophysiologic Mechanisms of Disease
  • 1.5.2 Chronic Anovulation
  • 1.5.3 Obesity
  • 1.5.4 Early Menarche and Late Menopause
  • 1.5.5 Estrogen-Secreting Tumors
  • 1.6 Exogenous Estrogen Exposure
  • 1.6.1 Unopposed Estrogen Therapy
  • 1.6.2 Postmenopausal Hormone Replacement Therapy
  • 1.6.3 Tamoxifen, Other SERMs, and Aromatase Inhibitors
  • 1.7 Genetic Syndromes
  • 1.7.1 Family History
  • 1.7.2 Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome)
  • 1.7.3 Cowden Syndrome
  • 1.7.4 BRCA1 and BRCA2 Mutations
  • 1.8 Fertility-Associated Factors
  • 1.8.1 Nulliparity and Infertility
  • 1.8.2 Breastfeeding
  • 1.8.3 Contraceptives
  • 1.8.4 Tubal Ligation
  • 1.9 Other Associated Factors
  • 1.9.1 Diet and Phytoestrogens
  • 1.9.2 Ultraviolet Radiation, Calcium, and Vitamin D
  • 1.9.3 Exercise
  • 1.9.4 Diabetes and Hypertension
  • 1.9.5 Cigarette Smoking
  • 1.9.6 Alcohol
  • 1.9.7 Coffee and Tea
  • 1.9.8 Aspirin
  • 1.10 Summary
  • References
  • 2: Cytogenetic Mechanisms in Endometrial Cancer
  • 2.1 Introduction
  • 2.2 Classification of EC
  • 2.2.1 Clinicopathological Classification
  • 2.2.2 Genetic Classification
  • 2.3 Role of Estrogen
  • 2.3.1 Imbalance Between Estrogen-Induced Endometrial Proliferation and Mismatch Repair System
  • 2.3.2 Dysregulation of Different Genetic Factors by Estrogen
  • 2.4 Mechanisms Involved in Genesis of EC at Cytogenetic Level
  • 2.4.1 Epigenetics
  • 2.4.2 Abnormal Mismatch Repair (MMR) System
  • 2.4.3 Gene Mutation
  • 2.4.3.1 Tumor Suppressor Genes
  • 2.4.3.2 Oncogenes
  • 2.4.4 MicroRNA
  • 2.5 Cytogenetic Basis of Different Characteristics of EC
  • 2.5.1 Myometrial Invasion
  • 2.5.2 Apoptosis Resistance
  • 2.5.3 Resistance to Ionizing Radiation Treatment
  • 2.6 Conclusion
  • References
  • 3: Endometrial Precancers: Diagnosis and Management
  • 3.1 Introduction
  • 3.2 Etiology
  • 3.3 Classification
  • 3.3.1 Endometrial Intraepithelial Neoplasia
  • 3.4 Comparison Between WHO and EIN Classification
  • 3.5 Clinical Features
  • 3.6 Diagnosis
  • 3.6.1 Ultrasound
  • 3.6.2 Office Endometrial Biopsy
  • 3.6.3 Hysteroscopy and Targeted Biopsy
  • 3.6.4 CT/MRI/Biomarkers
  • 3.7 Management
  • 3.7.1 Observation
  • 3.7.2 Medical Management
  • 3.7.2.1 Progestin
  • 3.7.2.2 Clomiphene or Aromatase Inhibitors
  • 3.7.2.3 Metformin
  • 3.7.2.4 GnRH Agonist
  • 3.7.2.5 Danazol

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