Mechanisms of vascular disease : a textbook for vascular specialists /
Saved in:
Edition: | 3rd edition. |
---|---|
Imprint: | Cham, Switzerland : Springer, 2020. |
Description: | 1 online resource |
Language: | English |
Subject: | |
Format: | E-Resource Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12606838 |
Table of Contents:
- Intro
- Contents
- Abbreviations
- Chapter 1: Vascular Endothelium in Health and Disease
- 1.1 Introduction
- 1.2 Endothelium-Dependent Regulation of Vascular Tone
- 1.2.1 Gaseous Mediators
- 1.2.2 Endothelium-Dependent Hyperpolarisation
- 1.2.3 Metabolites of Arachidonic Acid
- 1.2.4 Endothelins
- 1.3 Angiogenesis
- 1.4 Haemostasis
- 1.5 Inflammation
- 1.6 Conclusions
- References
- Further Reading
- Chapter 2: Pathophysiology of Atherosclerosis
- 2.1 Introduction
- 2.2 Normal Vessel Wall
- 2.3 Stages of Atherosclerosis
- 2.3.1 Intimal Xanthomas or Fatty Streaks
- 2.3.2 Fibroatheroma
- 2.3.3 Thin-Cap Fibroatheroma
- 2.3.4 Plaque Rupture
- 2.3.5 Fibrous Calcified Plaque
- 2.3.6 Plaque Erosion
- 2.4 Pathophysiology of Atherosclerosis and Atherothrombosis
- 2.4.1 Endothelial Dysfunction
- 2.4.2 Lipoprotein Entry and Modification
- 2.4.3 Leukocyte Recruitment
- 2.4.4 Foam Cell Formation
- 2.4.5 Lymphocyte Responses
- 2.4.6 Smooth Muscle Cell Migration and Fibrous Cap Formation
- 2.4.7 Macrophage Apoptosis and Necrotic Core Formation
- 2.4.8 Calcification
- 2.4.9 Neovascularisation and Intraplaque Haemorrhage
- 2.4.10 Fibrous Cap Degradation and Plaque Rupture
- 2.4.11 Plaque Erosion
- 2.5 The Role of Inflammation in Atherosclerosis
- 2.6 Risk Factors
- 2.6.1 Genetic Risk Factors
- 2.6.2 Traditional Risk Factors
- 2.7 Conclusion
- References
- Further Reading
- Chapter 3: Mechanisms of the Vulnerable Atherosclerotic Plaque and Imaging
- 3.1 Introduction
- 3.2 Plaque Rupture
- 3.2.1 Thin Cap Fibroatheromas
- 3.2.2 Plaque Size and Positive Luminal Remodeling
- 3.2.3 Lipid-Rich Necrotic Core
- 3.2.4 Neovascularisation and Plaque Haemorrhage
- 3.2.5 Calcification
- 3.3 Plaque Erosion
- 3.4 Calcified Nodules
- 3.5 Effect of Diabetes on Plaque Morphology
- 3.6 Carotid Imaging
- 3.6.1 Carotid Ultrasound
- 3.6.2 Carotid Computed Tomography
- 3.6.3 Carotid Magnetic Resonance Imaging
- 3.7 Molecular Imaging
- 3.7.1 Imaging Inflammation: Fluorodeoxyglucose (18F-FDG)
- 3.7.2 Imaging Microcalcification: Sodium Fluoride (18F-NaF)
- 3.8 Intravascular Imaging
- 3.8.1 Intravascular Ultrasound (IVUS)
- 3.8.2 Optical Coherence Tomography (OCT)
- 3.8.3 Intravascular Molecular Imaging
- 3.9 Conclusion: Vulnerable Plaques and Vulnerable Patients
- References
- Further Reading
- Chapter 4: Current and Emerging Therapies for Atherosclerosis
- 4.1 Introduction
- 4.2 Risk Stratification
- 4.3 Lifestyle Measures
- 4.4 Anti-platelet and Anti-thrombotic Therapies
- 4.5 Blood Pressure Therapies
- 4.6 LDL Cholesterol Lowering Therapies
- 4.7 Additional Lipid Modifying Therapies
- 4.8 Glucose Lowering Therapies
- 4.9 Anti-Inflammatory Therapies
- 4.10 Obesity Targeted Therapies
- 4.11 Cardiac Rehabilitation
- 4.12 Conclusion
- References
- Further Reading
- Chapter 5: Pathophysiology of Angiogenesis and Its Role in Vascular Disease
- 5.1 Introduction