Structure, function and regulation of Tor complexes from yeasts to mammals. Part A /

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Bibliographic Details
Edition:	1st ed.
Imprint:	Amsterdam ; Boston : Academic Press, 2010.
Description:	1 online resource (xii, 404 pages, 4 unnumbered pages of plates) : illustrations (some color).
Language:	English
Series:	The enzymes ; v. 27 Enzymes ; v. 27.
Subject:	Rapamycin. Immunosuppressive agents. Immunosuppressive agents. Rapamycin. Sirolimus. Immunosuppressive Agents. TOR Serine-Threonine Kinases.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/12616284

Hidden Bibliographic Details
Other authors / contributors:	Hall, Michael N. Tamanoi, Fuyuhiko.
ISBN:	9780123815408 0123815401 9780123815392 0123815398
Notes:	Includes bibliographical references and indexes. Print version record.
Summary:	Cell growth is highly regulated and is controlled by the TOR signaling network. Dysfunction of signaling pathways controlling cell growth results in cells of altered sizes and in turn causes developmental errors and a wide range of pathological conditions. An understanding of the TOR signaling network may lead to novel drugs for the treatment of, for example, €cancer, diabetes, inflammation, muscle atrophy, learning disabilities, depression, obesity and aging. There has been an explosion of knowledge in this area in recent years and this volume provides an in-depth review of our current knowledge of TOR complexes by the leadersin the field.
Other form:	Print version: Structure, function and regulation of Tor complexes from yeasts to mammals. Part A. 1st ed. Amsterdam ; Boston : Academic Press, 2010 9780123815392

Table of Contents:

TOR Complexes: Composition, Structure, and Phosphorylation
Regulation of TOR Signaling in Mammals
Rheb G-Proteins and the Activation of mTORC1
Regulation of TOR Complex 1 by Amino Acids Through Small GTPases
Rag GTPases in TORC1 Activation and Nutrient Signaling
Amino Acid Regulation of hVps34 and mTORC1 Signaling
AGC Kinases in mTOR Signaling
mTORC1 and Cell Cycle Control
TORC1 Signaling in Budding Yeast
TORC2 and Sphingolipid Biosynthesis and Signaling: Lessons from Budding Yeast
TORC1 Signaling in the Budding Yeast Endomembrane System and Control of Cell-Cell Adhesion in Pathogenic Fungi
TOR and Sexual Development in Fission Yeast
Fission Yeast TOR and Rapamycin
Structure of TOR Complexes in Fission Yeast
Stucture of TOR Complexes in Fission Yeast
The TOR Complex and Signaling Pathway in Plants
Dysregulation of TOR Signaling in Tuberous Sclerosis and Lymphangioleiomyomotosis
Chemistry and Pharmacology of Rapamycin and Its Derivatives.

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