Review by Choice Review
Genomics technology can successfully edit the DNA of human germ line cells, allowing a manipulated genome to be passed down to subsequent generations. While germline editing can be used to eradicate some inheritable diseases, it could also accidentally and permanently write unintended features--good, bad, or even ugly ones--into the genome of whole human lineages. Such capability raises apprehension and moral concerns. This book represents the official report of an international commission of notables on the acceptability of heritable human genome editing (HHGE) and on determining the kind of knowledge that will be needed before considering HHGE to be safe. Although the text is written in dry, technocratic language, making few concessions to engaging style, it is clear and precise. The report comprises four substantive sections addressing the state of the science, potential applications, translational paths toward controlled clinical applications, and national and international governance. Each section incorporates the essential definitions and facts, also establishing the general criteria that should govern pertinent discussion, and each concludes with a set of recommendations. Didactic images and diagrams addressing the nonexpert consumer and a glossary are included. This report is a must-have for anyone working on genetics, biomedical ethics, or related public policy, and also provides an accessible resource for the general reader. Summing Up: Highly recommended. All readers. --Pablo Rodriguez del Pozo, Weill Cornell Medical College
Copyright American Library Association, used with permission.
Review by Choice Review