Bone cancer : bone sarcomas and bone metastases - from bench to bedside /

Bone cancer : bone sarcomas and bone metastases - from bench to bedside /

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Bibliographic Details
Edition:Third edition.
Imprint:Amsterdam : Academic Press, 2021.
Description:1 online resource : illustrations (black and white, and color).
Language:English
Subject:
Bones -- Cancer.
Bone metastasis.
Bone Neoplasms.
Bone Neoplasms -- therapy.
Bone metastasis.
Bones -- Cancer.
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/12659809
Hidden Bibliographic Details
Other authors / contributors:Heymann, Dominique, editor.
ISBN:9780128216668
0128216662
Notes:Print version record.
Summary:Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.
Other form:Print version: Bone cancer. Third edition. Amsterdam : Academic Press, 2021 9780128216668
Table of Contents:
  • Front Cover
  • Bone Cancer
  • Bone Cancer: Bone Sarcomas and Bone Metastases
  • From Bench to Bedside
  • Copyright
  • Contents
  • Contributors
  • Foreword I
  • Foreword II
  • Foreword III
  • Preface
  • I
  • Basic Aspects of Bone Cancers
  • I
  • Epidemiology of Bone Cancers
  • 1
  • Cancer: lessons to learn from the past
  • Introduction
  • Who studies cancer(s) in ancient people(s)?
  • How do we recognize cancer in the past?
  • What do we know about the past of cancer? a global perspective
  • Documental evidence
  • Bioarchaeological evidence
  • Lessons from case-driven research
  • Lessons from population-driven research
  • Limits and pitfalls of paleo-oncology
  • Conclusion and perspectives
  • Acknowledgments
  • References
  • 2
  • Epidemiology of primary bone tumors and economical aspects of bone metastases
  • Incidence of primary bone tumors
  • Age
  • Gender
  • Site distribution
  • Incidence of bone tumors as a secondary event
  • Racial differences in incidence of primary bone tumors
  • Incidence of bone metastases
  • Pathology of bone metastases
  • Cost of illness
  • Economic burden of bone metastasis
  • Conclusions
  • Acknowledgments
  • References
  • II
  • Animal Models of Bone Cancers
  • 3
  • Mammalian models of bone sarcomas
  • Introduction
  • Models based on the inoculation of cancer cells and the implantation of tumor fragments
  • Genetically engineered animal models
  • Conclusion
  • Acknowledgments
  • References
  • 4
  • In vivo models used in studies of bone metastases
  • Introduction
  • Models used in the studies of breast cancer bone metastases (Table 4.1)
  • Xenograft models
  • Intracardiac injection
  • Mechanisms of bone metastasis formation
  • Effects of therapies
  • Intravenous/intra-arterial injection
  • Mechanisms of bone metastasis formation
  • Effects of therapies
  • Intraosseous implantation
  • Mechanisms of bone metastasis formation
  • Effects of therapies
  • Syngeneic models
  • Mechanisms of bone metastasis formation
  • Effects of therapies
  • In vivo models of prostate cancer bone metastases (Table 4.2)
  • Xenograft models
  • Intracardiac injection
  • Mechanisms of bone metastasis formation
  • Effects of therapies
  • Intratibial implantation
  • Mechanisms of metastasis
  • Effects of therapies
  • Orthotopic implantation
  • Syngeneic models
  • Modeling metastasis to/in human bone (Table 4.3)
  • Murine models of myeloma-induced bone disease (Table 4.4)
  • Syngeneic murine models of MM
  • The 5T series of MM models
  • The 5T2 syngeneic model of MM
  • Tumor homing, colonization, and development
  • The effects of therapies
  • The 5T33 syngeneic model of MM (reduce)
  • Tumor homing, colonization, and development
  • The effects of therapies
  • The 5TGM1 syngeneic model of MM
  • Tumor homing, colonization, and development
  • The effects of therapies
  • Transgenic models of MM
  • Xenograft models of MM
  • SCID-xenograft models of MM
  • Tumor homing, colonization, and development

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