Hyperpolarized carbon-13 magnetic resonance imaging and spectroscopy /
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| Imprint: | [Place of publication not identified] : Academic Press, 2021. |
|---|---|
| Description: | 1 online resource |
| Language: | English |
| Series: | Advances in magnetic resonance technology and applications ; v. 3 Advances in magnetic resonance technology and applications ; v. 3. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12874149 |
Table of Contents:
- Front Cover
- HYPERPOLARIZED CARBON-13 MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY
- HYPERPOLARIZED CARBON-13 MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY
- Copyright
- Series list
- Contents
- Contributors
- Preface
- Organization
- Prerequisites
- Acknowledgments
- 1
- The physics of dissolution Dynamic Nuclear Polarization
- 1.1 Introduction
- 1.2 Polarization, magnetization, sensitivity, and hyperpolarization
- 1.3 Methods of hyperpolarization
- 1.4 Dynamic Nuclear Polarization
- 1.4.1 Solid effect
- 1.4.2 Cross-effect and thermal mixing
- 1.5 The DNP sample: formulation of the imaging agent and the electron paramagnetic agent
- 1.6 Dissolution and relaxation
- 1.7 Conclusion
- References
- 2
- Hardware for preparing HP 13C-molecules: from polarizer to patient
- 2.1 Requirements for DNP
- 2.1.1 The magnet
- 2.1.2 Cryogenic environment
- 2.1.3 Microwaves
- 2.1.4 The sample
- 2.2 Monitoring of solid-state 13C polarization
- 2.3 Rapid state change
- 2.4 Preclinical dDNP
- 2.5 Postdissolution
- 2.6 Clinical dDNP
- 2.6.1 Quality control
- 2.7 Future developments
- 2.8 Conclusions
- Acknowledgments
- References
- 3
- HP acquisition methods: pulse sequences, reconstruction, and RF coils
- 3.1 Introduction
- 3.2 Hyperpolarized imaging considerations
- 3.2.1 T1 decay and nonrecoverable magnetization
- 3.2.2 RF decay and metabolism
- 3.2.3 Chemical shift displacement
- 3.3 Pulse sequences and reconstruction
- 3.3.1 Nonselective spectroscopy and CSI
- 3.3.2 Fast spectroscopic imaging
- 3.3.3 IDEAL CSI
- 3.3.4 Metabolite-selective imaging
- 3.3.5 Pulse sequence summary
- 3.4 RF coils
- 3.4.1 Surface and volume coils
- 3.4.2 Multichannel arrays and coil combination
- 3.5 Summary
- References
- 4
- HP experimental methods: cells and animals
- 4.1 Introduction
- 4.2 Dissolution-What is in it?
- 4.3 Transfer to the magnet-how fast can you run?
- 4.4 Delivery-how much and how to?
- 4.4.1 How much of the hyperpolarized agent is sufficient?
- 4.4.2 How to deliver the hyperpolarized agent?
- 4.5 Preclinical model systems for testing of hyperpolarized 13C agents
- 4.5.1 Models used for feasibility testing
- 4.5.2 Models used for HP agent development for a predetermined biomedical application
- 4.5.3 Preclinical animal models used in hyperpolarized NMR
- 4.6 Understanding and interpreting the hyperpolarized signals to shed light on the underlying biochemistry of the pathology
- Acknowledgments
- References
- Further study
- 5
- HP agents and biochemical interactions
- 5.1 Introduction
- 5.1.1 Main differences between 1H MRI and HP 13C spectroscopy and imaging
- 5.1.2 Ideal characteristics of an HP 13C agent
- 5.1.3 Carbon-13 magnetic resonance and labeled metabolic substrates
- 5.2 Overview of biological HP agents
- 5.2.1 [1-13C]pyruvate
- 5.2.2 [1,4-13C2]Fumarate
- 5.2.3 Carbohydrates
- 5.2.4 Fatty acids and ketone bodies