Evaluating evidence of mechanisms in medicine : principles and procedures /
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Author / Creator: | Parkkinen, Veli-Pekka. |
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Imprint: | Cham, Switzerland : Springer Open, [2018] |
Description: | 1 online resource (xviii, 125 pages) : illustrations |
Language: | English |
Series: | Springer briefs in philosophy, SpringerBriefs in philosophy. |
Subject: | |
Format: | E-Resource Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/13397430 |
Table of Contents:
- 1 Introduction
- 1.1 What is a mechanism?
- 1.2 Where does evidence of a mechanism come from?
- 1.3 Why consider evidence of mechanisms?
- 1.3.1 Evaluating efficacy
- 1.3.2 Evaluating external validity
- 1.3.3 Other questions
- 1.3.4 Importance of considering evidence of mechanisms
- 2 How to consider evidence of mechanisms: a summary
- 2.1 Questions to address
- 2.2 Quality level of evidence and status of claim
- 2.3 Identifying evidence of mechanisms in the literature
- 2.4 Evaluating evidence of mechanisms
- 2.5 Using evidence of mechanisms to evaluate causal claims
- 2.6 Overall approach
- 3 Identifying evidence of mechanisms in the literature
- 3.1 Hypothesize a mechanism
- 3.2 Search the literature
- 3.3 Identify the evidence most relevant to the mechanism hypothesis
- 3.4 Presenting the evidence of mechanisms
- 4 Evaluating evidence of mechanisms
- 4.1 Considerations for evaluating evidence of mechanism
- 4.2 Presenting quality of evidence of mechanisms
- 5 Using evidence of mechanisms to evaluate efficacy and external validity
- 5.1 Efficacy
- 5.2 External validity
- 6 Glossary
- 7 References
- 8 Acknowledgements
- 9 Appendix A.A critical appraisal tool for evidence of mechanisms
- 10 Appendix B. GRADE tables with mechanism assessment
- 11 Appendix C: Databases for evidence of mechanisms
- 12 Appendix D: Assessing exposures
- 12.1 Example: carcinogenicity of benzo[a]pyrene
- 12.2 Comparison to IARC
- 12.3 Molecular epidemiology
- 12.4 Comparison to SYRINA.