Chromosome architecture : methods and protocols /

Chromosome architecture : methods and protocols /

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Bibliographic Details
Edition:	Second edition.
Imprint:	New York : Humana Press, [2022]
Description:	1 online resource (1 PDF file (xi, 330 pages)) : illustrations (chiefly color).
Language:	English
Series:	Methods in molecular biology, 1940-6029 ; 2476 Springer protocols Methods in molecular biology (Clifton, N.J.) ; v. 2476. Springer protocols (Series)
Subject:	Chromosomes -- Laboratory manuals. Chromatin. Chromosomes -- chemistry Chromatin Chromatin Assembly and Disassembly Genomics -- methods Chromosomes Laboratory Manual Laboratory manuals Laboratory manuals.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/13437718

Hidden Bibliographic Details
Other authors / contributors:	Leake, Mark C., editor.
ISBN:	9781071622216 1071622218 9781071622209 107162220X
Digital file characteristics:	text file PDF
Notes:	Includes bibliographical references and index. Description based on online resource; title from PDF title page (SpringerLink, viewed February 15, 2023).
Summary:	This detailed new edition collects cutting-edge laboratory protocols, techniques, and applications in use by some of the leading international experts in the broad field of chromosome architecture. The book emphasizes the increasing physiological relevance of chromosome architecture investigation, manifest both through application of more complex bottom-up assays in vitro as well as through maintaining the native physiological context through the investigation of living, functional cells. In addition, the chapters reflect the dramatic improvement in the length scale of precision by utilizing single-molecule approaches, both for imaging the DNA content of chromosome and proteins that bind to DNA as well as using methods that can controllably manipulate single DNA molecules, and the use of advanced computational methods and mathematical analysis is also featured. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Chromosome Architecture: Methods and Protocols, Second Edition is an ideal guide for researchers working in this dynamic area of study.
Other form:	Print version: Chromosome architecture. Second edition. New York : Humana Press, [2022] 107162220X 9781071622209
Standard no.:	10.1007/978-1-0716-2221-6

Description
Physical Description:	1 online resource (1 PDF file (xi, 330 pages)) : illustrations (chiefly color).
Bibliography:	Includes bibliographical references and index.
ISBN:	9781071622216 1071622218 9781071622209 107162220X
ISSN:	1940-6029 ;