Cancer chemotherapy and biotherapy : principles and practice /

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Bibliographic Details
Edition:	Fifth edition.
Imprint:	Philadelphia : Wolters Kluwer Health/Lippincott Williams & Wilkins, [2011] ©2011
Description:	1 online resource (836 pages) : illustrations (some color)
Language:	English
Subject:	Cancer -- Chemotherapy. Cancer -- Immunotherapy. Antineoplastic agents. Biological response modifiers. Immunologic Factors Antineoplastic agents Biological response modifiers Cancer -- Chemotherapy Cancer -- Immunotherapy
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/13441441

Hidden Bibliographic Details
Other authors / contributors:	Chabner, Bruce. Longo, Dan L. (Dan Louis), 1949- ProQuest (Firm)
ISBN:	9781605474311
Notes:	Includes bibliographical references and index.
Summary:	"Updated to include the newest drugs and those currently in development, Cancer Chemotherapy and Biotherapy, Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents--their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Chapters emphasize pharmacology and mechanisms of action at the molecular and cellular levels, followed by clinical activity and toxicity, both acute and delayed. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. The previous edition was one of "Doody's Core Titles 2009." This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised"--Provided by publisher.
Other form:	Print version: Cancer chemotherapy and biotherapy : principles and practice. Philadelphia : Wolters Kluwer Health/Lippincott Williams & Wilkins, [2011] xv, 812 pages, 4 unnumbered pages of plates ; 29 cm 9781605474311

Table of Contents:

Section 1. Basic Principles Of Cancer Treatment
1. Clinical Strategies for Cancer Treatment: The Role of Drugs
2. Target Identification and Drug Discovery
3. Clinical Drug Development and Approval for Marketing
4. Principles of Pharmacokinetics
5. Special Aspects of Brain Tumor Chemotherapy
6. Pharmacogenetics
7. Barriers to Drug Delivery
Section 2. Cytotoxic Agents
8. Antifolates
9. Fluoro-pyrimidines
10. Cytidine Analogues
11. Purine Analogues
12. Hydroxyurea
13. Antimitotic Drugs
14. Alkylating Agents (Including Methylating Agents)
15. Platinum Analogues
16. Antitumor Antibiotics (Including Bleomycin)
17. Topoisomerase I Inhibitors
18. Topoisomerase II Inhibitors: Anthracyclines
19. Topoisomerase II Inhibitors: Etoposide, Teniposide
20. L-Asparaginase
Section 3. Molecularly Targeted Therapies
21. Proteosome Inhibitors
22. HDAC Inhibitors
23. Differentiating Agents (Retinoids)
24. Arsenic Trioxide
25. Monoclonal Antibodies: Discovery & Development
26. Anti-angiogenic Agents (Including MonAB)
27. Anti-EGFR Therapies (Including MonAB)
28. Anti-her 2 Therapies
29. Intracellular Signal Inhibitors (bcr-abl)
30. Signal Transduction Inhibitors in Development
31. Inhibitors of the PI3k Pathway & Mitotic Kinase
Section 4. Immunologic Agents
32. Interferon and Cytokines
33. Vaccines
34. Adoptive Cellular Therapies
35. Immuno-modulatory Drugs (IMIDS, Anti-CTLA4)
Section 5. Hormonal Therapy
36. Hormonal Therapy of Breast Cancer
37. GNRH Agonists and Anti-Androgens
Section 6. Supportive Care
38. Pain Management in Cancer Patients
39. Colony Stimulating Factors
40. Anti-nausea Medications
41. Bone Loss Modulators
42. Intravenous Access and Catheter Management
Section 7. Survivorship
43. Monitoring for Late Side Effects of Chemotherapy

Cancer chemotherapy and biotherapy : principles and practice /

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