Searching for a mechanism : a history of cell bioenergetics /

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Bibliographic Details
Author / Creator:	Prebble, J. N. (John N.), author.
Imprint:	New York, NY : Oxford University Press, 2018.
Description:	1 online resource : illustrations
Language:	English
Subject:	Bioenergetics -- History. Energy metabolism. Cell physiology. Energy Metabolism Cell Physiological Phenomena Biochemistry -- history Bioenergetics. History.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/13541245

Hidden Bibliographic Details
ISBN:	9780190866150 0190866152 9780190866143 0190866144
Notes:	Includes bibliographical references and index. Print version record.
Summary:	Searching for a Mechanism traces the history of cell bioenergetics from the early notions of science in the Enlightenment through to the end of the twentieth century. Author John N. Prebble's treatment of this history falls into five periods, from the 1600's to the present day. The "bioenergetics revolution" has long been overlooked because it occurred simultaneously as the other major biological revolution of the twentieth century: the development of molecular biology. This book aims to provide the first thorough history of bioenergetics. The story of cell bioenergetics is primarily concerned with the synthesis of ATP (adenosine triphosphate), sometimes referred to as the energy currency of the cell. In fact the term 'bioenergetics' was probably not introduced into the field until Albert Szent-Gyorgyi published a small book under that title in 1957. 0Despite the twentieth century focus of the subject matter, the history of this field commences with the work of those in the seventeenth century who sought to understand the process of breathing and passes through metabolic biochemistry concluding with the elucidation of the molecular mechanisms of key enzymes in bioenergetics. Although the story of metabolic biochemistry (which is often taken to include bioenergetics) essentially belongs to the twentieth century, progress in this area cannot be understood without recourse to previous centuries. Thus from the seventeenth century onwards it is possible to trace a path of early thinking which eventually laid the ground work for the dramatic success of twentieth century studies
Other form:	Print version: Prebble, J.N. (John N.). Searching for a mechanism. New York, NY : Oxford University Press, 2018 9780190866143

Table of Contents:

Cover; Searching for a Mechanism; Copyright; Dedication; Contents; Preface; Acknowledgments; List of Abbreviations; 1. Introduction: Respiration, phosphorylation, and mechanism; 1.1 Respiration, photosynthesis, and bioenergetics; 1.2 Vitalism; 1.3 Historical questions; 1.4 Phosphorylation; 1.5 Mechanisms; 1.6 The relevance of cell bioenergetics to the question of mechanism; 2. From physiology to biochemistry: Respiration and oxidation from 1600 to 1900; 2.1 Initiation of the experimental study of respiration; 2.2 John Mayow's Tractatus Quinque; 2.3 Stephen Hales's Vegetable Staticks
2.4 Respiration and combustion2.5 The location of respiration; 2.6 Thermodynamic questions; 2.7 Bernard's criticism of slow combustion; 2.8 Hofmeister's integration of cell biology; 2.9 O2 and oxidation; 2.10 Spectroscopy, hemoglobin, and animal pigments; 2.11 Cell-free systems; 3. Relating phosphorylation, respiration, and oxidation: 1900-1945; 3.1 Resolving nineteenth-century questions; 3.2 Achievements of the first half of the twentieth century; 3.3 Yeast and animal juices: The importance of phosphate; 3.4 Thunberg, Wieland, and the nature of biological oxidation
3.5 Warburg's Atmungsferment3.6 Keilin's cytochrome; 3.7 DPN (NAD) and its oxidation; 3.8 Muscle, lactic acid, and energy; 3.9 Adenosine triphosphate and muscle phosphates; 3.10 Aerobic ATP synthesis: Engelhardt and Kalckar; 3.11 Phosphorylation linked to respiration: Belitzer and Ochoa; 3.12 Lipmann: The significance of phosphorylation; 4. Emergence of the field of cell bioenergetics: 1945-1960; 4.1 Emergence of a new field; 4.2 The mitochondrion as the location of respiratory activity; 4.3 Further elucidation of the respiratory chain; 4.4 Phosphorylation; 4.5 Sites for phosphorylation
4.6 Seeking to understand the mechanism of phosphorylation4.7 The phosphorylating enzyme; 4.8 Fragmenting mitochondria; 4.9 Physiological aspects of mitochondria; 5. Defining the mechanism: 1960-1977; 5.1 What mechanism?; 5.2 The first proton theory: Robert J. P. Williams; 5.3 The chemiosmotic hypothesis of Peter Mitchell; 5.4 Revising the respiratory chain; 5.5 Exploring the ATP synthase; 5.6 Reconstituting oxidative phosphorylation; 5.7 Bacteriorhodopsin; 5.8 Conformational theories; 5.9 Mitochondrial membranes; 5.10 Ion movements across the mitochondrial membrane
5.11 Resolving the mechanism6. Discovering photosynthesis; 6.1 The development of ideas on photosynthesis; 6.2 Initial studies of photosynthesis; 6.3 The importance of water and CO2; 6.4 Energy; 6.5 Discovering chlorophyll and chloroplasts; 6.6 Understanding the nature of photosynthesis; 6.7 Photosynthetic bacteria and an oxidation-reduction mechanism; 6.8 Light and dark reactions; 6.9 O2 evolution and the Hill reaction; 6.10 CO2 assimilation; 6.11 Discovering photophosphorylation; 7. Elucidating the photosynthetic light reaction; 7.1 The fourth period of photosynthetic history

Searching for a mechanism : a history of cell bioenergetics /

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