WNT signaling in development and disease /

WNT signaling in development and disease /

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Bibliographic Details
Imprint:Cambridge, MA : Academic Press, 2023.
Description:1 online resource
Language:English
Series:Current topics in developmental biology ; v. 153
Current topics in developmental biology ; v. 153.
Subject:
Wnt proteins.
Cellular signal transduction.
Cellular signal transduction.
Wnt proteins.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/13565425
Hidden Bibliographic Details
Other authors / contributors:Yamaguchi, Terry P.
Willert, Karl.
ISBN:9780128201640
0128201649
9780128201671
0128201673
Notes:Print version record.
Other form:Original 0128201673 9780128201671
Print version: WNT SIGNALING IN DEVELOPMENT AND DISEASE. [S.l.] : ELSEVIER ACADEMIC PRESS, 2023 0128201673
Table of Contents:
  • Intro
  • Wnt Signaling in Development and Disease
  • Copyright
  • Contents
  • Contributors
  • Preface
  • References
  • Chapter One: The logistics of Wnt production and delivery
  • 1. Wnt production and delivery: A complex logistical problem
  • 2. Lipidation
  • 2.1. An unusual lipid modification
  • 2.2. Porcupine: An enzyme dedicated to Wnt lipidation
  • 3. Glycosylation
  • 4. Progression through the secretory pathway
  • 4.1. Wntless escorts Wnts through the secretory pathway
  • 4.2. Binding of Wnts to Wntless
  • 4.3. Other players acting in the ER and Golgi
  • 5. Beyond Wls
  • 5.1. Wnt trafficking in epithelial cells
  • 5.2. Let Wnt go
  • 6. Transport and gradient formation
  • 6.1. Juxtacrine signaling
  • 6.2. Evidence for long range signaling
  • 6.3. Long range signaling by cytonemes
  • 6.4. Long range signaling by diffusion
  • 7. Wnt interactions with HSPGs and glypicans
  • 7.1. HSPGs modulate multiple signaling pathways
  • 7.2. The role of glypicans in Wnt transport
  • 8. Other means of shielding the Wnt lipid in the extracellular space
  • 9. Wnts reach their receptors: Handover and initiation of signaling
  • 10. How a lipidated morphogen came to be during evolution
  • Acknowledgments
  • References
  • Chapter Two: Visualizing WNT signaling in mammalian systems
  • 1. Introduction
  • 2. Imaging individual players at the molecular level
  • 2.1. The signalosome
  • 2.1.1. WNT ligands
  • 2.1.2. Frizzled/LRP and disheveled
  • 2.2. The CTNNB1 destruction complex and enhanceosome
  • 2.2.1. Destruction complex
  • 2.2.2. CTNNB1
  • 2.2.3. TCF/LEF
  • 3. Imaging signaling output at the cellular level
  • 3.1. A brief history of TCF/LEF reporters
  • 3.2. 7x TCF-GFP in cell lines
  • 3.3. WNT reporters in mice
  • 3.3.1. TCF/LEF reporters in mice
  • 3.3.2. Axin2 reporter strains
  • 4. Discussion and outlook
  • Acknowledgments
  • References.
  • 3.3. Developmental transitions through pluripotency stages are regulated by Wnt signaling
  • 4. Role of Wnts in gastrulation
  • 4.1. The primitive streak (PS) and early gastrulation
  • 4.2. Axial progenitors
  • 4.3. The trunk-to-tail transition
  • 4.4. Axial progenitors and retinoic acid
  • 5. Closing remarks
  • References
  • Chapter Six: Role of Wnt signaling and planar cell polarity in left-right asymmetry
  • 1. Canonical Wnt signaling regulates the formation of the node, the left-right organizer
  • 2. Non-canonical Wnt signaling and planar cell polarity determines the tilt of motile cilia at the node
  • 2.1. Motile and immotile cilia are required for establishing L-R asymmetry
  • 2.2. The tilt of motile cilia is determined by the position of the basal body in node cells
  • 2.3. Correct positioning of the basal body by planar cell polarity genes
  • 2.4. Graded distribution of Wnt5a activity along the antero-posterior axis of the mouse embryo polarizes node cells
  • 2.5. Microtubules and actomyosin provide pushing force for shifting the basal body position
  • 3. Canonical Wnt signaling in establishing asymmetric nodal activity at the node
  • 4. Conclusions
  • Acknowledgments
  • References
  • Chapter Seven: Non-canonical WNT5A-ROR signaling: New perspectives on an ancient developmental pathway
  • 1. A brief history of canonical and non-canonical WNT pathways
  • 2. Emergence of WNT5A-ROR signaling as a major non-canonical WNT pathway
  • 3. Robinow syndrome as a disorder of WNT5A-ROR signaling
  • 4. Molecular insights from Robinow syndrome and related disease mutations
  • 4.1. WNT5A
  • 4.2. ROR2
  • 4.3. Dishevelleds
  • 4.4. Frizzled 2
  • 5. Growing connections to cancer metastasis
  • 6. Cell biological functions of WNT5A-ROR signaling
  • 7. Concluding remarks
  • Acknowledgments
  • References.
  • Chapter Eight: The role of Wnt signaling in Xenopus neural induction
  • 1. Introduction
  • 1.1. Neural induction from newt to frog
  • 1.2. The anatomy of the Xenopus gastrula/neurula embryo
  • 2. The arising of embryonic signaling centers
  • 2.1. The Nieuwkoop center and the formation of the Spemann organizer
  • 3. The Wnt pathway discovery and its impact on X. laevis embryogenesis
  • 3.1. How cancer biology and the Wnt pathway discovery impacted the understanding of Xenopus embryogenesis
  • 3.2. Revealing molecular induction properties: Is there room for one more organizer?
  • 4. The BMP signaling pathway and the neural default model
  • 5. WNT morphogen activity and its impact on Xenopus AP embryonic neural patterning
  • 5.1. Wnt inhibitors are involved in neural induction and head formation
  • 5.2. Wnt antagonists secreted from Spemann organizer
  • 5.3. Wnt antagonists secreted in Naïve ectoderm
  • 6. Concluding remarks
  • Acknowledgments
  • References
  • Chapter Nine: Wnt regulation of hematopoietic stem cell development and disease
  • 1. Hematopoietic stem cells-The source of our blood and immune cell pool
  • 2. In vivo models for hematopoietic stem cell development
  • 3. Wnt signaling
  • 4. Wnt signaling in HSC development and homeostasis
  • 5. Wnt signaling and hematological malignancies
  • 6. Epigenetic regulation in HSCs and Wnt signaling
  • 7. Conclusion
  • References
  • Chapter Ten: Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium
  • 1. Introduction
  • 2. Overview of the Wnt pathway
  • 3. Organization of the intestinal epithelium
  • 3.1. The organoid model
  • 4. Wnt pathway in intestinal homeostasis and regeneration
  • 4.1. Modulation of Wnt signaling during homeostasis
  • 4.2. Determination of the stem cell state
  • 4.3. Reconstituting the stem cell pool after injury.
  • 5. Regulation of Wnt signaling by the intestinal niche
  • 5.1. Paneth cells
  • 5.2. Deep crypt secretory cells
  • 5.3. Stromal cells
  • 5.4. Immune and lymphatic cells
  • 5.5. Nervous system
  • 5.6. Extracellular matrix
  • 5.7. Flora
  • 5.8. Nutrition
  • 6. Discussion
  • References
  • Chapter Eleven: Got WNTS? Insight into bone health from a WNT perspective
  • 1. Bone development
  • 2. Wnt signaling in limb development
  • 3. Wnt signaling and human skeletal malformations
  • 4. Wnt signaling and bone homeostasis
  • 5. Therapeutics and future directions
  • Acknowledgments
  • References
  • Chapter Twelve: Wnt signaling in whole-body regeneration
  • 1. Introduction
  • 2. Planarian regeneration is supported by pluripotent adult stem cells
  • 3. Planarians have constitutive Wnt positional information specified from muscle
  • 4. Injury-induced Wnt signals regulate the polarity of blastema outgrowth
  • 5. Constitutive Wnt gradients pattern the AP axis in homeostasis and regeneration
  • 6. Wnts control reestablishment of tissue proportionality in planarian regeneration
  • 7. Wnt signaling from muscle controls AP regeneration of the Acoel Hofstenia miamia
  • 8. Wnt signaling controls oral-aboral identity in whole-body regeneration of Cnidarians
  • 9. Concluding remarks
  • Acknowledgments
  • References
  • Chapter Thirteen: From injury to patterning-MAPKs and Wnt signaling in Hydra
  • 1. Introduction
  • 2. Wnt signaling in Hydra axis formation
  • 3. Autocatalytic Wnt activation and Wnt inhibitors in Hydra pattern formation
  • 4. Cell cycle dynamics of Hydra regeneration
  • 5. Transcriptomic and (phospho-) proteomic profiles of Hydra regeneration
  • 6. A dual role of Wnt signaling in regeneration
  • 7. The injury signal in Hydra
  • 7.1. ROS and calcium
  • 7.2. Mitogen activated protein kinases ERK, JNK, and p38
  • 7.3. Cell competition and apoptosis.

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