Molecular genetics of coronary artery disease : candidate genes and processes in atherosclerosis /
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| Imprint: | Basel ; New York : Karger, 1992. |
|---|---|
| Description: | xvii, 453 p. : ill. ; 25 cm. |
| Language: | English |
| Series: | Monographs in human genetics ; vol. 14 Monographs in human genetics v. 14. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/1383723 |
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| 245 | 0 | 0 | |a Molecular genetics of coronary artery disease : |b candidate genes and processes in atherosclerosis / |c volume editors, Aldons J. Lusis, Jerome I. Rotter, Robert S. Sparkes. |
| 260 | |a Basel ; |a New York : |b Karger, |c 1992. | ||
| 263 | |a 9209 | ||
| 300 | |a xvii, 453 p. : |b ill. ; |c 25 cm. | ||
| 336 | |a text |b txt |2 rdacontent |0 http://id.loc.gov/vocabulary/contentTypes/txt | ||
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| 490 | 1 | |a Monographs in human genetics ; |v vol. 14 | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | 0 | |t Pathology of Atherogenesis / |r J. A. Berliner and R. G. Gerrity. |t The Normal Vessel. |t The Pre-Fatty Streak Stage. |t The Fatty Streak. |t The Fibro-Fatty Lesion. |t The Fibrous Plaque. |t Thrombus Formation and Complicated Plaques. |t Comparison of Atherogenesis in the Swine Aorta with That Seen in Other Animal Models and in Human Lesions. |t Coronary Atherosclerosis -- |t Cellular Interactions of the Arterial Wall / |r M. C. Territo, J. A. Berliner and M. Navab. |t Adhesion of the Blood Cells to the Endothelium. |t Factors Involved in the Recruitment of Cells in the Vessel Wall. |t Growth Factors. |t Possible Candidate Genes -- |t Modified Low-Density Lipoproteins: Diversity and Biological Relevance in Atherogenesis / |r M. E. Haberland and U. P. Steinbrecher. |t The Dynamics of Low-Density Lipoprotein in the Arterial Wall. |t Classic Concept of Modified Low-Density Lipoprotein: Role in Cholesteryl Ester Deposition in Macrophages. |t NeoClassic Concepts of Modified Low-Density Lipoprotein: Roles in Cellular Activation. |t Candidate Genes for the Role of Modified Low-Density Lipoprotein in Atherogenesis -- |t Viral Genes and Atherogenesis / |r R. J. Kaner and D. P. Hajjar. |t Epidemiology. |t Pathobiology. |t Cellular and Molecular Effects. |t Molecular Genetics. |t Herpesvirus Entry into Vascular Cells. |t Viral Activation of the Immune System -- |t Mechanical Factors in Artery Wall Function and Atherogenesis / |r L. L. Demer. |t Lesion Distribution. |t Mechanical Forces Acting on the Artery Wall. |t Effects of Shear in vivo. |t Effects of Shear in vitro. |t Internal Wall Stretch/Stress. |t Effects of Pressure. |t Other Mechanical Forces -- |t Lipoprotein Metabolism: Chylomicrons, Very-Low-Density Lipoproteins and Low-Density Lipoproteins / |r V. Schumaker and A. Lembertas. |t Exogenous and Endogenous Pathways of Lipid Transport. |t Molecular Biology of Apolipoprotein B. |t Molecular Biology of Apolipoprotein E. |t Molecular Biology of the Low-Density Lipoprotein Receptor. |t Abetalipoproteinemia and Hypobetalipoproteinemia. |t Familial Defective Apolipoprotein B100. |t Familial Combined Hyperlipidemia. |t Familial Dysbetalipoproteinemia. |t Familial Hypercholesterolemia -- |t Lipoprotein Metabolism: High-Density Lipoprotein / |r S. K. Karathanasis. |t Overview of the Lipid Transport System. |t Definition of High-Density Lipoprotein. |t Structural Heterogeneity of High-Density Lipoprotein. |t Functional Diversity of High-Density Lipoprotein. |t Structure-Function Relationships of High-Density Lipoprotein. |t Origin of High-Density Lipoprotein. |t Metabolic Relationships: The Concept of Functional States of High-Density Lipoprotein. |t High-Density Lipoprotein-Cell Interactions. |t Cholesterol Efflux: The Aqueous Diffusion Model. |t Cholesterol Efflux: The High-Density Lipoprotein Receptor. |t Cholesterol Efflux: The Role of Intracellular Phospholipids and Protein Kinase C. |t Cloning of the High-Density Lipoprotein Receptor? |t Cholesterol Efflux: The Role of Apolipoprotein E. |t Catabolism of High-Density Lipoprotein. |t Environmental Factors Influencing Plasma Levels of High-Density Lipoprotein. |t Genetic Factors Influencing Plasma Levels of High-Density Lipoprotein. |t High-Density Lipoprotein and Atherosclerosis. |t Perspective -- |t Triglyceride Lipases, Hypertriglyceridemia and Atherosclerosis / |r M. H. Doolittle, A. Durstenfeld, A. S. Garfinkel and M. C. Schotz. |t Lipases and Triglyceride Metabolism. |t Molecular Genetics of Lipase-Based Hypertriglyceridemia. |t Triglycerides and Atherosclerosis -- |t Lp(a) Lipoprotein: An Important Genetic Risk Factor for Atherosclerosis / |r K. Berg. |t Discovery of the Lp(a) Lipoprotein System and Studies in the Early Years. |t Quantitative Lp(a) Lipoprotein Variation. |t A Distinct Class of Lipoprotein Particles. |t Relationship between Lp(a) Phenotypes and Lp(a) Lipoprotein Concentration. |t Methodological Problems in Lp(a) Lipoprotein Studies. |t Genetics of the Lp(a) Lipoprotein. |t Isoforms of the Lp(a) Polypeptide Chain. |t Lp(a) Lipoprotein and Atherosclerosis. |t Linkage Studies of Lp(a) Lipoprotein. |t Primary Structure of the Polypeptide Chain Carrying the Lp(a) Antigen(s). |t Possible Bridge between Atherogenesis and Thrombogenesis. |t Studies on the LPA Gene. |t Concerning the Control of Lp(a) Lipoprotein Levels -- |t Bile Acid Synthesis and the Enterohepatic Circulation: Processes Regulating Total Body Cholesterol Homeostasis / |r R. A. Davis, S. Dueland and J. D. Trawick. |t Enterohepatic Circulation of Bile Salts. |t Quantitative Importance of the Bile Acid Excretion in Whole-Body Cholesterol Homeostasis. |t Mechanisms to Regulate Cholesterol Homeostasis in Response to Dietary Cholesterol. |t Biochemical Description and Co-Factors. |t The Enterohepatic Circulation of Bile Acids. |t Physiologic Regulation. |t Candidate Genes That May Affect Cholesterol Homeostasis -- |t Molecular Genetics of Hypertension / |r W. Burke and A. G. Motulsky. |t Cation Transport Mechanisms. |t The Renin-Angiotensin System. |t Kallikreins. |t Atrial Natriuretic Factor. |t Other Approaches -- |t Hemostatic Factors in Ischemic Heart Disease and Stroke: Pathophysiologic Significance and Molecular Genetics / |r R. B. Francis, Jr. |t Hemostatic Abnormalities and Atherosclerotic Cardiovascular Disease. |t Molecular Genetics of Hemostatic Factors Linked to Atherosclerotic Cardiovascular Disease. |t Future Prospects -- |t Review of the Evidence that Immunogenetic Factors Are Involved in the Etiology of Atherosclerosis / |r R. T. Acton, R. C. P. Go and J. M. Roseman. |t Animal Studies. |t Presence of Immune Components in the Atherosclerotic Plaque. |t Clinical Studies Implicating Immune Factors. |t Population Studies. |t Genetics of the Immune System in Relation to Atherosclerosis. |t Immunogenetic Models of Atherosclerosis -- |t Diabetes mellitus and Coronary Heart Disease Genetics / |r T. Shohat, L. F. Raffel, C. M. Vadhaim and J. I. Rotter. |t Diabetes - Definition and Classification. |t Evidence for a Genetic Role in Diabetes. |t Genetic Studies in Insulin-Dependent Diabetes mellitus. |t Genetics of Non-Insulin-Dependent Diabetes mellitus. |t Diabetes and Atherosclerosis - Epidemiology. |t General Risk Factors for Atherosclerosis in Diabetes. |t Specific Risk Factors for Coronary Artery Disease in Diabetes. |t Role of Genetics in Diabetic Complications. |t Genetic Models for Diabetic Macrovascular Disease. |t Studies of Specific Genes. |t Summary and Future Studies -- |t Homocystinuria and Atherosclerosis / |r D. E. L. Wilcken and N. P. B. Dudman. |t Elevated Circulating Homocysteine. |t Genetically Determined Homocystinuria and Vascular Disease. |t Cystathionine [beta]-Synthase Deficiency. |t The Gene. |t Re-Methylating Disorders. |t Pathology. |t Mild Homocysteinaemia and Vascular Disease. |t Possible Mechanisms Leading to Vascular Disease. |t Established Facts. |t Unknowns -- |t Gene-Diet Interactions in Lipoprotein Metabolism / |r D. M. Dreon and R. M. Krauss. |t Low-Density Lipoprotein Receptor in Cholesterol Homeostasis. |t Apolipoprotein B. |t Apolipoprotein E. |t Defective High-Density Lipoprotein Metabolism. |t Low-Density Lipoprotein Subclass Patterns -- |t Molecular Geography of Inherited Disorders of Lipoprotein Metabolism: Lipoprotein Lipase Deficiency and Familial Hypercholesterolemia / |r M. R. Hayden, M. De Braekeleer, H. E. Henderson and J. Kastelein. |t The Flow of Genes - Molecular Geography. |t High Gene Frequencies for Disorders of Lipoprotein Metabolism. |t From France to Quebec: The Story of Lipoprotein Lipase Deficiency. |t From Bombay to Cape Town: The Origin of the [actual symbol not reproducible] Mutation in the Lipoprotein Lipase Gene in the Indian Population of South Africa. |t A Recurrent Mutation in the Lipoprotein Lipase Gene in Persons of Different Ancestries. |t Familial Hypercholesterolemia: The Origins of the Founder Effect in South African Afrikaners. |t Origins of Mutations Causing Familial Hypercholesterolemia in French Canadians -- |t Genetic Markers for Studies of Atherosclerosis and Related Risk Factors / |r M. Mehrabian and A. J. |
| 505 | 0 | 0 | |t Lusis. |t Approaches. |t Identification of Polymorphisms. |t Statistical Considerations. |t Candidate, Genes. |t Assessment of Problem -- |t Identification of New Genes Contributing to Atherosclerosis: The Mapping of Genes Contributing to Complex Disorders in Animal Models / |r C. H. Warden, A. Daluiski and A. J. Lusis. |
| 505 | 8 | 0 | |t The Difficulty of Identifying New Genes for Complex Diseases Using Human Studies Candidate Gene Approach. |t Identification of Loci for Complex Genetic Traits: Quantitative Trait Locus Mapping. |t Animal Models for Quantitative Trait Locus Mapping. |t From Loci to Genes and Mechanisms. |
| 650 | 0 | |a Atherosclerosis |x Genetic aspects. | |
| 650 | 0 | |a Atherosclerosis |x Pathophysiology. | |
| 650 | 0 | |a Coronary heart disease |x Etiology. |0 http://id.loc.gov/authorities/subjects/sh2009121921 | |
| 650 | 0 | |a Coronary heart disease |x Risk factors. |0 http://id.loc.gov/authorities/subjects/sh2009121922 | |
| 650 | 0 | |a Blood lipoproteins |x Metabolism |0 http://id.loc.gov/authorities/subjects/sh85014997 | |
| 650 | 2 | |a Atherosclerosis |x genetics | |
| 650 | 2 | |a Coronary Arteriosclerosis |x genetics | |
| 650 | 2 | |a Lipoproteins |x metabolism | |
| 650 | 7 | |a Atherosclerosis |x Genetic aspects. |2 fast |0 http://id.worldcat.org/fast/fst00820012 | |
| 650 | 7 | |a Atherosclerosis |x Pathophysiology. |2 fast |0 http://id.worldcat.org/fast/fst00820016 | |
| 650 | 7 | |a Blood lipoproteins |x Metabolism. |2 fast |0 http://id.worldcat.org/fast/fst00834769 | |
| 650 | 7 | |a Coronary heart disease |x Etiology. |2 fast |0 http://id.worldcat.org/fast/fst00879544 | |
| 650 | 7 | |a Coronary heart disease |x Risk factors. |2 fast |0 http://id.worldcat.org/fast/fst00879562 | |
| 700 | 1 | |a Lusis, Aldons J., |d 1947- |0 http://id.loc.gov/authorities/names/n88087884 |1 http://viaf.org/viaf/112901710 | |
| 700 | 1 | |a Rotter, Jerome I. |0 http://id.loc.gov/authorities/names/n80123641 |1 http://viaf.org/viaf/64065545 | |
| 700 | 1 | |a Sparkes, Robert S., |d 1930- |0 http://id.loc.gov/authorities/names/n77006758 |1 http://viaf.org/viaf/112901723 | |
| 830 | 0 | |a Monographs in human genetics |v v. 14. |0 http://id.loc.gov/authorities/names/n84800826 | |
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