Molecular genetics of coronary artery disease : candidate genes and processes in atherosclerosis /
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| Imprint: | Basel ; New York : Karger, 1992. |
|---|---|
| Description: | xvii, 453 p. : ill. ; 25 cm. |
| Language: | English |
| Series: | Monographs in human genetics ; vol. 14 Monographs in human genetics v. 14. |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/1383723 |
Table of Contents:
- Pathology of Atherogenesis / J. A. Berliner and R. G. Gerrity. The Normal Vessel. The Pre-Fatty Streak Stage. The Fatty Streak. The Fibro-Fatty Lesion. The Fibrous Plaque. Thrombus Formation and Complicated Plaques. Comparison of Atherogenesis in the Swine Aorta with That Seen in Other Animal Models and in Human Lesions. Coronary Atherosclerosis
- Cellular Interactions of the Arterial Wall / M. C. Territo, J. A. Berliner and M. Navab. Adhesion of the Blood Cells to the Endothelium. Factors Involved in the Recruitment of Cells in the Vessel Wall. Growth Factors. Possible Candidate Genes
- Modified Low-Density Lipoproteins: Diversity and Biological Relevance in Atherogenesis / M. E. Haberland and U. P. Steinbrecher. The Dynamics of Low-Density Lipoprotein in the Arterial Wall. Classic Concept of Modified Low-Density Lipoprotein: Role in Cholesteryl Ester Deposition in Macrophages. NeoClassic Concepts of Modified Low-Density Lipoprotein: Roles in Cellular Activation. Candidate Genes for the Role of Modified Low-Density Lipoprotein in Atherogenesis
- Viral Genes and Atherogenesis / R. J. Kaner and D. P. Hajjar. Epidemiology. Pathobiology. Cellular and Molecular Effects. Molecular Genetics. Herpesvirus Entry into Vascular Cells. Viral Activation of the Immune System
- Mechanical Factors in Artery Wall Function and Atherogenesis / L. L. Demer. Lesion Distribution. Mechanical Forces Acting on the Artery Wall. Effects of Shear in vivo. Effects of Shear in vitro. Internal Wall Stretch/Stress. Effects of Pressure. Other Mechanical Forces
- Lipoprotein Metabolism: Chylomicrons, Very-Low-Density Lipoproteins and Low-Density Lipoproteins / V. Schumaker and A. Lembertas. Exogenous and Endogenous Pathways of Lipid Transport. Molecular Biology of Apolipoprotein B. Molecular Biology of Apolipoprotein E. Molecular Biology of the Low-Density Lipoprotein Receptor. Abetalipoproteinemia and Hypobetalipoproteinemia. Familial Defective Apolipoprotein B100. Familial Combined Hyperlipidemia. Familial Dysbetalipoproteinemia. Familial Hypercholesterolemia
- Lipoprotein Metabolism: High-Density Lipoprotein / S. K. Karathanasis. Overview of the Lipid Transport System. Definition of High-Density Lipoprotein. Structural Heterogeneity of High-Density Lipoprotein. Functional Diversity of High-Density Lipoprotein. Structure-Function Relationships of High-Density Lipoprotein. Origin of High-Density Lipoprotein. Metabolic Relationships: The Concept of Functional States of High-Density Lipoprotein. High-Density Lipoprotein-Cell Interactions. Cholesterol Efflux: The Aqueous Diffusion Model. Cholesterol Efflux: The High-Density Lipoprotein Receptor. Cholesterol Efflux: The Role of Intracellular Phospholipids and Protein Kinase C. Cloning of the High-Density Lipoprotein Receptor? Cholesterol Efflux: The Role of Apolipoprotein E. Catabolism of High-Density Lipoprotein. Environmental Factors Influencing Plasma Levels of High-Density Lipoprotein. Genetic Factors Influencing Plasma Levels of High-Density Lipoprotein. High-Density Lipoprotein and Atherosclerosis. Perspective
- Triglyceride Lipases, Hypertriglyceridemia and Atherosclerosis / M. H. Doolittle, A. Durstenfeld, A. S. Garfinkel and M. C. Schotz. Lipases and Triglyceride Metabolism. Molecular Genetics of Lipase-Based Hypertriglyceridemia. Triglycerides and Atherosclerosis
- Lp(a) Lipoprotein: An Important Genetic Risk Factor for Atherosclerosis / K. Berg. Discovery of the Lp(a) Lipoprotein System and Studies in the Early Years. Quantitative Lp(a) Lipoprotein Variation. A Distinct Class of Lipoprotein Particles. Relationship between Lp(a) Phenotypes and Lp(a) Lipoprotein Concentration. Methodological Problems in Lp(a) Lipoprotein Studies. Genetics of the Lp(a) Lipoprotein. Isoforms of the Lp(a) Polypeptide Chain. Lp(a) Lipoprotein and Atherosclerosis. Linkage Studies of Lp(a) Lipoprotein. Primary Structure of the Polypeptide Chain Carrying the Lp(a) Antigen(s). Possible Bridge between Atherogenesis and Thrombogenesis. Studies on the LPA Gene. Concerning the Control of Lp(a) Lipoprotein Levels
- Bile Acid Synthesis and the Enterohepatic Circulation: Processes Regulating Total Body Cholesterol Homeostasis / R. A. Davis, S. Dueland and J. D. Trawick. Enterohepatic Circulation of Bile Salts. Quantitative Importance of the Bile Acid Excretion in Whole-Body Cholesterol Homeostasis. Mechanisms to Regulate Cholesterol Homeostasis in Response to Dietary Cholesterol. Biochemical Description and Co-Factors. The Enterohepatic Circulation of Bile Acids. Physiologic Regulation. Candidate Genes That May Affect Cholesterol Homeostasis
- Molecular Genetics of Hypertension / W. Burke and A. G. Motulsky. Cation Transport Mechanisms. The Renin-Angiotensin System. Kallikreins. Atrial Natriuretic Factor. Other Approaches
- Hemostatic Factors in Ischemic Heart Disease and Stroke: Pathophysiologic Significance and Molecular Genetics / R. B. Francis, Jr. Hemostatic Abnormalities and Atherosclerotic Cardiovascular Disease. Molecular Genetics of Hemostatic Factors Linked to Atherosclerotic Cardiovascular Disease. Future Prospects
- Review of the Evidence that Immunogenetic Factors Are Involved in the Etiology of Atherosclerosis / R. T. Acton, R. C. P. Go and J. M. Roseman. Animal Studies. Presence of Immune Components in the Atherosclerotic Plaque. Clinical Studies Implicating Immune Factors. Population Studies. Genetics of the Immune System in Relation to Atherosclerosis. Immunogenetic Models of Atherosclerosis
- Diabetes mellitus and Coronary Heart Disease Genetics / T. Shohat, L. F. Raffel, C. M. Vadhaim and J. I. Rotter. Diabetes - Definition and Classification. Evidence for a Genetic Role in Diabetes. Genetic Studies in Insulin-Dependent Diabetes mellitus. Genetics of Non-Insulin-Dependent Diabetes mellitus. Diabetes and Atherosclerosis - Epidemiology. General Risk Factors for Atherosclerosis in Diabetes. Specific Risk Factors for Coronary Artery Disease in Diabetes. Role of Genetics in Diabetic Complications. Genetic Models for Diabetic Macrovascular Disease. Studies of Specific Genes. Summary and Future Studies
- Homocystinuria and Atherosclerosis / D. E. L. Wilcken and N. P. B. Dudman. Elevated Circulating Homocysteine. Genetically Determined Homocystinuria and Vascular Disease. Cystathionine [beta]-Synthase Deficiency. The Gene. Re-Methylating Disorders. Pathology. Mild Homocysteinaemia and Vascular Disease. Possible Mechanisms Leading to Vascular Disease. Established Facts. Unknowns
- Gene-Diet Interactions in Lipoprotein Metabolism / D. M. Dreon and R. M. Krauss. Low-Density Lipoprotein Receptor in Cholesterol Homeostasis. Apolipoprotein B. Apolipoprotein E. Defective High-Density Lipoprotein Metabolism. Low-Density Lipoprotein Subclass Patterns
- Molecular Geography of Inherited Disorders of Lipoprotein Metabolism: Lipoprotein Lipase Deficiency and Familial Hypercholesterolemia / M. R. Hayden, M. De Braekeleer, H. E. Henderson and J. Kastelein. The Flow of Genes - Molecular Geography. High Gene Frequencies for Disorders of Lipoprotein Metabolism. From France to Quebec: The Story of Lipoprotein Lipase Deficiency. From Bombay to Cape Town: The Origin of the [actual symbol not reproducible] Mutation in the Lipoprotein Lipase Gene in the Indian Population of South Africa. A Recurrent Mutation in the Lipoprotein Lipase Gene in Persons of Different Ancestries. Familial Hypercholesterolemia: The Origins of the Founder Effect in South African Afrikaners. Origins of Mutations Causing Familial Hypercholesterolemia in French Canadians
- Genetic Markers for Studies of Atherosclerosis and Related Risk Factors / M. Mehrabian and A. J.
- Lusis. Approaches. Identification of Polymorphisms. Statistical Considerations. Candidate, Genes. Assessment of Problem
- Identification of New Genes Contributing to Atherosclerosis: The Mapping of Genes Contributing to Complex Disorders in Animal Models / C. H. Warden, A. Daluiski and A. J. Lusis.
- The Difficulty of Identifying New Genes for Complex Diseases Using Human Studies Candidate Gene Approach. Identification of Loci for Complex Genetic Traits: Quantitative Trait Locus Mapping. Animal Models for Quantitative Trait Locus Mapping. From Loci to Genes and Mechanisms.
