Genetic factors in drug therapy : clinical and molecular pharmacogenetics /
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| Author / Creator: | Price Evans, David A. |
|---|---|
| Imprint: | Cambridge [England] ; New York : Cambridge University Press, 1993. |
| Description: | xxiii, 657 p. : ill. ; 26 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/1624769 |
Table of Contents:
- Preface
- Part I. Introduction
- 1. The arrangement of the information in this volume
- 2. General introduction
- 3. Classification of pharmacogenetic phenomena
- Part II. Cytochrome P450 Based Phenomen
- 4. Cytochrome P450 - general features
- 5. Artlhydrocarbon hydroxylase (cytochrome P450 1A1 and 1A2)
- 6. The mephenytoin hydroxylation polymorphism (cytochrome P450 2C18)
- 7. The debrisoquine/sparteine polymorphism (cytochrome P450 2D6)
- 8. The cytochrome P450 3A subfamily
- 9. Tolbutamide
- 10. Phenytoin
- 11. Some other drugs of special interest
- 12. Cytochrome P450 reductase
- 13. General conclusions
- Part III. Cholinesterase
- 14. Cholinesterase
- Part IV. Alcohol and Alcoholism
- 15. Alcohol and alcoholism
- Part V. N-Acetyltransferase
- 16. N-Acetyltransferase
- Part VI. Miscellaneous Phase II Reactions Showing Genetic Variability in Drug Metabolism
- 17. The glucosidation of amobarbital
- 18. Glucuronosyltransferases
- 19. Glutathione-S-transferase
- 20. Methylation reactions
- 21. Paraoxonase
- 22. Sulphotransferases
- 23. Sulphoxidation deficiency
- 24. Halothane hepatitis and other topics
- Part VII. Glucose-6-Phosphate Dehydrogenase Deficiency
- 25. Glucose-6-phosphate dehydrogemase deficiency
- Part VIII. The Hepatic Porphyrias
- 26. The hepatic porphyrias
- Part IX. Malignant Hyperthermia
- 27. Malignant hyperthermia
- Part X. Miscellaneous Systems Showing Genetic Variability in Response to Drugs
- 28. Chlorpropamide-alcohol flushing
- 29. Glucocorticosteroids and intraocular pressure
- 30. Unstable haemoglobins
- 31. Human lymphocyte antigens and adverse reactions to drugs
- 32. The polymorphism for tasting phenylthiocarbamide (PTC syn phenylthiourea)
- 33. Hereditary anticoagulant resistance
- 34. NADH-cytochrome b5 reductase
- 35. Catalase
- 36. Antibiotic-induced deafness, chloramphenicol toxicity and other topics
- Part XI. Polygenic Effects in Pharmacogenetics
- 37. Polygenic effects in pharmacogenetics
- Part XII. Common Themes
- 38. Common themes
- Part XIII. Conclusions
- 39. Conclusions
- Part XIV. Appendices: Index
