Bacterial pathogenesis : a molecular approach /
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| Author / Creator: | Salyers, Abigail A. |
|---|---|
| Imprint: | Washington, D.C. : ASM Press, c1994. |
| Description: | xxvii, 418 p. : ill. (some col.) ; 28 cm. |
| Language: | English |
| Subject: | |
| Format: | E-Resource Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/1625355 |
Table of Contents:
- Preface
- Foreword
- Part I. Basic Principles
- Chapter 1. The Uneasy Truce: Never Underestimate the Power of Bacteria
- Why Bacteria Are Once Again in the Public Health Spotlight
- Ancient History Takes a Toll on Today's Human Health
- Pressing Current Issues
- New Solutions, New Hope
- And Now for the Really Good News--You've Got a Bacterial Infection
- Chapter 2. Approaching and Studying Bacterial Diseases
- Microbes and Disease
- Measuring Infectivity and Virulence
- Chapter 3. Molecular Approaches to the Diagnosis and Characterization of Bacterial Infections
- Seeking Insights into Virulence
- Molecular Microbe Hunting
- Identifying Virulence Factors Experimentally
- Chapter 4. The First Line of Defense against Infection: Prevention and the Phagocytic Cell Response
- An Ounce of Prevention
- Nonspecific and Specific Defenses
- Epithelia
- Defenses of Skin
- Defenses of Mucosal Surfaces
- Phagocytes and Nonspecific Cytotoxic Cells: Defenders of Blood and Tissue
- Chapter 5. The First Line of Defense, Continued: Complement, Chemokines, and Cytokines
- Characteristics and Roles of Complement
- Steps in Complement Activation
- Role of Cytokines and Chemokines in Directing the Phagocyte Response
- Other Activities of Cytokines
- Stress and Resistance to Disease: Connections between the Nervous System and the Immune System
- The Dark Side of the Nonspecific Defenses: Septic Shock
- Chapter 6. The Second Line of Defense: Antibodies and Cytotoxic T Cells
- Antibodies
- Cytotoxic T Cells
- Production of Activated Cytotoxic T Cells and Antibodies
- Mucosal Immunity
- Development of the Specific Response System from Infancy to Adulthood
- The Dark Side of the Specific Defenses--Autoimmune Disease
- Chapter 7. Vaccination--an Underappreciated Component of the Modern Medical Armamentarium
- Vaccines--a Major Health Care Bargain
- A New Form of Child Abuse (as if We Needed One)
- The Success Stories
- The Less-than-Success Stories
- New Directions
- Passive Immunization
- Chapter 8. Bacterial Strategies for Evading or Surviving the Defense Systems of the Human Body
- Overview of Bacterial Defense Strategies
- Colonization and Invasion of Host Surfaces
- Evading Complement, Phagocytes, and the Antibody Response
- Chapter 9. Bacterial Exotoxins: Important but Still a Mystery
- Exotoxins, Toxic Proteins Produced by Bacteria
- Examples of Diseases Caused by Toxins
- Chapter 10. Antimicrobial Compounds
- Antimicrobial Compounds: the Safety Net of Modern Medicine
- Antiseptics and Disinfectants
- Antibiotics
- Mechanisms of Antibiotic Action
- The Continuing Challenge
- Chapter 11. How Bacteria Become Resistant to Antibiotics
- The Dawning of Awareness
- Mechanisms of Antibiotic Resistance
- Antibiotic Tolerance
- Transfer of Resistance Genes
- Will We Return to the Preantibiotic Era?
- Part II. Specific Bacterial Pathogens
- Chapter 12. The Spirochetes: Borrelia burgdorferi and Treponema pallidum
- Lyme Disease
- Features of B. burgdorferi
- The Borrelia Genome Sequence--Some Clues but Still Many Mysteries
- The Tick-Mammal Cycle
- Response of B. burgdorferi to Its Arthropod and Mammalian Hosts
- Studying Virulence Factors of B. burgdorferi
- Diagnosis and Prevention of Lyme Disease
- Syphilis and Lyme Disease: Two Spirochetal Diseases with a Similar Pathology but a Different Ecology
- Taking Stock
- Chapter 13. Yersinia pestis, the Cause of Plague, and Its Relatives
- The Rich and Terrible History of Yersinia pestis
- Virulence Factors of Y. pestis, Y. enterocolitica, and Y. pseudotuberculosis
- Future Directions
- Chapter 14. Staphylococcus Species
- The Many Types of Staphylococcal Infections
- Characteristics of Staphylococci
- Virulence Factors of S. aureus
- Virulence Factors of the Coagulase-Negative Staphylococci
- Future Directions
- Chapter 15. Group A and Group B Streptococci and Enterococci
- A Closer Look at Diseases Caused by Streptococci
- Group B Streptococci and Enterococci--Emerging Human Pathogens
- Virulence Factors
- Chapter 16. Pseudomonas aeruginosa and Related Species, a Lesson in Versatility
- A Consummate Opportunist
- Characteristics of P. aeruginosa
- Types of Infections
- Virulence Factors
- Future Directions
- Chapter 17. Bordetella pertussis
- Whooping Cough
- Virulence Factors
- Regulation of Virulence Genes
- Prevention and Treatment
- Chapter 18. Streptococcus pneumoniae
- Pneumococcal Disease
- Virulence Factors of S. pneumoniae
- Prevention and Treatment
- Chapter 19. Tuberculosis
- A Disease of the Past Returns To Haunt the Future
- Spread and Progression of Tuberculosis
- Mycobacterium tuberculosis and Its Unusual Cell Wall--a Case of Fat Making for Lean and Mean
- Treatment of TB and the Challenge Posed by Drug-Resistant Strains
- Diagnosis of TB
- Virulence Factors
- Immunity to TB
- Chapter 20. Legionella pneumophila and Legionnaires' Disease
- The Dark Side of Modern Comforts: Air-Conditioning Turns Ugly
- Legionnaires' Disease
- The Natural Host?--a Free-Living Macrophage Equivalent
- Virulence Factors
- Prevention and Treatment
- Legionella as a Paradigm for Intracellular Pathogens
- Chapter 21. Mycoplasma pneumoniae and Chlamydia pneumoniae
- Lifestyles of Mycoplasma pneumoniae and Chlamydia pneumoniae
- Characteristics of Mycoplasma and Chlamydia Species
- Virulence Factors
- Chapter 22. Bacillus anthracis, the Cause of Anthrax
- Features of the Disease
- Virulence Factors
- Prevention of Anthrax
- Chapter 23. Helicobacter pylori, a Resourceful Gastric Pathogen
- A Revolution in Gastroenterology
- Characteristics of H. pylori
- Virulence Factors
- Prevention and Treatment
- H. pylori Mysteries
- Chapter 24. Clostridium difficile and Pseudomembranous Colitis
- Pseudomembranous Colitis--a Disease Caused by Antibiotics
- Characteristics of C. difficile
- Development and Ecology of the Disease
- Virulence Factors
- Prevention and Treatment
- Chapter 25. Vibrio cholerae, the Cause of Cholera
- Pathogenesis and Epidemiology of Cholera
- Virulence Factors
- Transcriptional Regulation of Virulence Genes
- Prevention and Treatment
- Future Directions
- Chapter 26. Salmonella Species
- Salmonella Species and Serogroups
- Diseases Caused by Salmonella Species
- Virulence Factors
- Prevention and Treatment
- Future Directions
- Chapter 27. Listeria monocytogenes, a Doubly Motile Pathogen
- Listeriosis
- Virulence Factors
- Organization and Regulation of Virulence Genes
- Prevention and Treatment
- Chapter 28. Diarrheagenic Escherichia coli Strains
- Different Types of Diarrheagenic Escherichia coli Strains
- Classification of Pathogenic E. coli Strains
- Virulence Factors
- Prevention and Treatment
- Chapter 29. Escherichia coli Extraintestinal Infections
- Epidemiology of Urinary Tract Infections
- Virulence Factors of E. coli Strains That Cause Urinary Tract Infections
- Meningitis and Other Disseminated Infections
- Prevention and Treatment
- Chapter 30. Neisseria Species
- The Two Pathogenic Neisseria Species
- Gonorrhea
- Meningococcal Meningitis
- Virulence Factors
- Prevention and Treatment
- Chapter 31. Chlamydia trachomatis
- The Hidden Epidemic
- C. trachomatis--a Lot of Pathogenic Potential in a Very Small Package
- Virulence Factors
- Prevention and Treatment
- Closing Observations
- Appendix 1. Overview of Bacterial Secretion Systems, Bacterial Adhesins and Their Mechanisms of Assembly, and Major Bacterial Toxins
- A.. Secretion Systems of Bacteria
- B.. Adhesins and Mechanisms of Assembly
- C.. Major Bacterial Toxins
- Appendix 2. Answers to End-of-Chapter Questions
- Glossary
- Index
