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|g I.
|t Introduction: Organizational Principles /
|r V. J. Desmet --
|g II.
|t The Cells.
|g A.
|t The Hepatocyte: Organization.
|g 1.
|t Biology and Pathobiology of Actin in the Liver /
|r M. James Phillips.
|g 2.
|t Cytoskeleton: Intermediate Filaments /
|r Samuel W. French.
|g 3.
|t Motor Molecules of the Cytoskeleton: Possible Functions in the Hepatocyte /
|r Peter Satir.
|g 4.
|t Genetic Control of Hepatocyte Differentiation /
|r Kenneth S. Zaret.
|g 5.
|t mRNA Metabolism in Higher Eukaryotes /
|r Joe B. Harford.
|g 6.
|t Gene Expression During Pathophysiologic States /
|r Antonello Pietrangelo and David A. Shafritz.
|g 7.
|t Hormonal Control of Gene Expression /
|r Johanna M. Beekman, Lawrence Chan and Ming-Jer Tsai.
|g 8.
|t Cytokines and the Acute Phase Response of the Liver /
|r Georg H. Fey, Gertrud M. Hocke, Deborah R. Wilson, Juergen A. Ripperger, Todd S.-C. Juan, Mei-Zhen Cui and Gretchen J. Darlington.
|g 9.
|t The Hepatocyte Plasma Membrane: Organization and Differentiation /
|r David Schachter.
|g 10.
|t Plasma Membrane: Biogenesis and Turnover /
|r Mamadi Yilla and Darrell Doyle.
|g 11.
|t Hepatocyte Basolateral Membrane Organic Anion Transporters /
|r Allan W. Wolkoff.
|g 12.
|t Hepatocyte Surface Polarity /
|r Ann L. Hubbard, Valarie A. Barr and Laura J. Scott.
|g 13.
|t The Endoplasmic Reticulum-Golgi Membrane System /
|r Jennifer Lippincott-Schwartz.
|g 14.
|t Degradation of Cytoplasmic Proteins /
|r Ronald M. Skurat and J. Fred Dice.
|g 15.
|t Mechanisms of Nuclear Entry /
|r John A. Hanover.
|g 16.
|t Receptor-Mediated Endocytosis /
|r Guojun Bu and Alan L. Schwartz.
|g 17.
|t Lysosomes /
|r G. Gary Sahagian and Phyllis M. Novikoff.
|g 18.
|t Peroxisomes /
|r Paul B. Lazarow.
|g 19.
|t Mitochondria /
|r Peter C. Hinkle.
|t The Hepatocyte: Metabolism /
|r William B. Jakoby.
|g 20.
|t Energy Metabolism /
|r Sam Seifter and Sasha Englard.
|g 21.
|t The Urea Cycle: Enzymes and Defects /
|r Mary G. Ampola.
|g 22.
|t Hepatic Cholesterol Metabolism /
|r Z. Reno Vlahcevic, Phillip B. Hylemon and John Y. L. Chiang.
|g 23.
|t Lipoprotein Metabolism /
|r Robert M. Glickman and Seymour M. Sabesin.
|g 24.
|t Detoxication: Oxidation and Reduction /
|r Daniel M. Ziegler.
|g 25.
|t Detoxication: Conjugation and Hydrolysis /
|r William B. Jakoby.
|g 26.
|t Protective Mechanism Against Reactive Oxygen Species /
|r Masayasu Inoue.
|g 27.
|t S-Adenosylmethionine and the Liver /
|r Jose M. Mato, Luis Alvarez, Fernando J. Corrales and Maria A. Pajares.
|g 28.
|t Heme and Bile Pigment Metabolism /
|r Jayanta Roy Chowdhury, Namita Roy Chowdhury, Allan W. Wolkoff and Irwin M. Arias.
|g 29.
|t Heme Biosynthesis, the Porphyrias, and the Liver /
|r Elizabeth E. Wyckoff and James P. Kushner.
|g 30.
|t Retinoid (Vitamin A) Metabolism and the Liver /
|r William S. Blaner.
|g 31.
|t Vitamin D: Photobiology, Metabolism, and Clinical Application /
|r Michael F. Holick.
|g 32.
|t Liver in Relation to Water-Soluble Vitamins /
|r Donald B. McCormick and Hamish N. Munro.
|g 33.
|t Copper and Zinc /
|r Irmin Sternlieb.
|g 34.
|t The Liver and Iron /
|r Stephen P. Young and Philip Aisen.
|g B.
|t Bile Secretion /
|r David Schachter.
|g 35.
|t The Biology of Biliary Epithelia /
|r Gianfranco Alpini, John O. Phillips and Nicholas F. LaRusso.
|g 36.
|t Vesicular Trafficking in the Hepatocyte /
|r Michael H. Nathanson and James L. Boyer.
|g 37.
|t The Biology of the Bile Canaliculus /
|r Zenaida C. Gatmaitan, Cynthia R. Leveille-Webster and Irwin M. Arias.
|g 38.
|t Bile Acids /
|r Alan F. Hofmann.
|g 39.
|t Enterohepatic Circulation /
|r Martin C. Carey and William C. Duane.
|g 40.
|t Bile Flow /
|r Serge Erlinger.
|g C.
|t Sinusoidal Cells /
|r Irwin M. Arias.
|g 41.
|t Kupffer and Sinusoidal Endothelial Cells /
|r Johan Kuiper, Adriaan Brouwer, Dick L. Knook and Theo J. C. van Berkel.
|g 42.
|t Fat-Storing (Ito) Cell Biology /
|r Albert Geerts, Pieter De Bleser, Marc L. Hautekeete, Toshiro Niki and Eddie Wisse.
|g D.
|t Extracellular Matrix /
|r Nelson Fausto.
|g 43.
|t The Extracellular Matrix of the Liver /
|r Marcos Rojkind and Patricia Greenwel.
|g 44.
|t Extracellular Matrix Regulation of Growth and Gene Expression in Liver Cell Lineages and Hepatomas /
|r Shlomo Brill, Patricia A. Holst, Isabel Zvibel, Anthony S. Fiorino, Samuel H. Sigal, Usha Somasundaran and Lola M. Reid.
|g 45.
|t Cell-Extracellular Matrix Interactions /
|r Erkki Ruoslahti, Michael D. Pierschbacher and Wayne A. Border --
|g III.
|t Interrelated Cell Functions /
|r Nelson Fausto.
|g 46.
|t Signal Transduction and Growth Control /
|r Lewis Cantley.
|g 47.
|t G Protein Function and Diversity: Regulation of cAMP as a Model System /
|r David R. Manning and Marilyn J. Woolkalis.
|g 48.
|t Role of Inositol Trisphosphate and Diacylglycerol in the Regulation of Liver Function /
|r John H. Exton.
|g 49.
|t Intracellular Calcium Signals in Hepatocytes /
|r Colin W. Taylor.
|g 50.
|t Gap Junctions in Liver: Composition, Function, and Regulation /
|r David C. Spray, Juan C. Saez, Elliot L. Hertzberg and Rolf Dermietzel.
|g 51.
|t Insulin, Insulin-Like Growth Factors, and their Receptors /
|r Neil Ruderman, Alan C. Moses and David E. Moller.
|g 52.
|t Interleukin-1 and Related Cytokines /
|r Charles A. Dinarello.
|g 53.
|t Leukotrienes and Other Eicosanoids in Liver Pathophysiology /
|r Dietrich Keppler.
|g 54.
|t Nitric Oxide and the Liver /
|r Paul D. Freeswick, David A. Geller, Jack R. Lancaster, Jr. and Timothy R. Billiar.
|g 55.
|t Hepatocyte Growth Factor: Its Role in Hepatic Growth and Pathobiology /
|r Reza Zarnegar, Marie C. DeFrances and George K. Michalopoulos.
|g 56.
|t Liver Regeneration /
|r Nelson Fausto and Eric M. Webber --
|g IV.
|t The Organ /
|r David Schachter.
|g 57.
|t The Hepatic Microvascular System /
|r Robert S. McCuskey.
|g 58.
|t Flow, Cell Entry, Metabolic Disposal, and Product Formation in the Liver /
|r Carl A. Goresky, Andreas J. Schwab and K. Sandy Pang.
|g 59.
|t The Biology of the Liver Cell Plate /
|r Jorge J. Gumucio, Bahri M. Bilir, Richard H. Moseley and Caryn M. Berkowitz --
|g V.
|t Relation of the Liver to Other Organs /
|r James L. Boyer.
|g 60.
|t Interaction of Liver, Muscle, and Adipose Tissue in the Regulation of Metabolism in Response to Nutritional and Other Factors /
|r Marc K. Hellerstein and Hamish N. Munro.
|g 61.
|t Hepatic Encephalopathy /
|r Roger F. Butterworth.
|g 62.
|t The Hypothalamic-Pituitary-Liver Axis: Growth Hormone Controls Liver Sex /
|r Jan-Ake Gustafsson.
|g 63.
|t Vitamin K-Dependent Blood Coagulation Proteins /
|r Barbara C. Furie and Bruce Furie.
|g 64.
|t The Hemopoietic Functions of the Liver /
|r Allan J. Erslev.
|g 65.
|t The Kidney in Liver Disease /
|r Murray Epstein.
|g 66.
|t Hepatobiliary Influences on the Skeletal System /
|r Joel B. Mason and Irwin H. Rosenberg.
|g 67.
|t Molecular Aspects of Autoimmune Liver Disease /
|r Ian R. Mackay --
|g VI.
|t Pathobiologic Analysis of Disease Mechanisms /
|r Nelson Fausto.
|g 68.
|t Cholestasis /
|r Jurg Reichen and Francis R. Simon.
|g 69.
|t The Biology of Portal Hypertension /
|r Paul Genecin and Roberto J. Groszmann.
|g 70.
|t Portal Hypertension: Clinical Pathobiology /
|r Jaume Bosch, Joan Carles Garcia-Pagan, Faust Feu and Juan Rodes.
|g 71.
|t [alpha[subscript 1]]-Antirypsin: Molecular Defects /
|r Richard N. Sifers, Milton J. Finegold and Savio L. C. Woo.
|g 72.
|t Liver Fibrosis /
|r Patricia Greenwel, Albert Geerts, Itsuro Ogata, Jose-Antonio Solis-Herruzo and Marcos Rojkind.
|g 73.
|t Ethanol and the Liver /
|r Francis R. Weiner, Silvia Degli Esposti and Mark A. Zern.
|g 74.
|t Immune Mechanisms of Cellular Injury in Viral Hepatitis /
|r Carlo Ferrari and Francis V. Chisari.
|g 75.
|t Viral Mechanisms in Hepatic Oncogenesis /
|r Sanjeev Gupta and David A. Shafritz.
|g 76.
|t The Woodchuck Model of Hepatitis B Virus Infection /
|r Bud C. Tennant and John L. Gerin.
|g 77.
|t Chemical Induction of Hepatic Neoplasia /
|r Henry C. Pitot and Yvonne P. Dragan --
|g VII.
|t Horizons /
|r Irwin M. Arias.
|g 78.
|t Liver Stem Cells /
|r Nelson Fausto.
|g 79.
|t Hepatocyte Transplantation /
|r Sanjeev Gupta and Jayanta Roy Chowdhury.
|g 80.
|t Gene Therapy by Targeting Nucleic Acids to Hepatocytes /
|r George Y. Wu and Catherine H. Wu.
|g 81.
|t Apoptosis: A Widespread Process Involved in Liver Adaptation and Carcinogenesis /
|r Franziska A. Oberhammer and Ruth A. Roberts.
|g 82.
|t Regulation of the Eukaryotic Cell Cycle /
|r Helen M. Piwnica-Worms.
|g 83.
|t The Immunosuppressants, Cyclosporin A and FK-506, and their Mechanisms of Action /
|r Francis J. Dumont.
|g 84.
|t Transgenic Mice: Designing Genes for Molecular Models /
|r Glenn Merlino.
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