Human heredity : principles and issues /
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| Author / Creator: | Cummings, Michael R. |
|---|---|
| Edition: | 3rd ed. |
| Imprint: | St. Paul, MN : West Pub., c1994. |
| Description: | xxiii, 601 p. : ill. (some col.) ; 27 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/1695964 |
Table of Contents:
- Chapter 1. Genetics as a Human Endeavor
- Welcome to Genetics
- What Are Genes and How do They Work?
- How Are Genes Transmitted from Parents to Offspring?
- How do Scientists Study Genes?
- What Is the Historical Impact of Genetics on Society?
- When Did Human Genetics Get Started?
- Where Is Human Genetics Going in the Future?
- Chapter 2. Cells, Chromosomes, and Cell Division
- There Are Two Main Cell Types: Prokaryotic and Eukaryotic
- Cell Structure Reflects Function
- The Cell Cycle Describes the Life History of a Cell
- Mitosis Is Essential for Growth and Cell Replacement
- Cell Division by Meiosis: the Basis of Sex
- Spermatogenesis and Oogenesis Are Processes That form Gametes
- Chapter 3. Transmission of Genes from Generation to Generation
- Heredity: How Are Traits Inherited?
- Mendel's Experimental Design Resolved Many Unanswered Questions
- Crossing Pea Plants: Mendel's Study of Single Traits
- More Crosses with Pea Plants: the Principle of Independent Assortment
- Meiosis Explains Mendel's Results: Genes Are on Chromosomes
- Many Genes Have More Than Two Alleles
- Variations on a Theme by Mendel
- Mendelian Inheritance in Humans
- Chapter 4. Pedigree Analysis in Human Genetics
- Studying the Inheritance of Traits in Humans
- Pedigree Analysis is a Basic Method in Human Genetics
- There Is a Catalog of Human Genetic Traits
- Pedigree Analysis for Autosomal Recessive Traits
- Pedigree Analysis for Autosomal Dominant Traits
- Sex-Linked Inheritance Involves Genes on the X and Y Chromosomes
- Pedigree Analysis for X-Linked Dominant Traits
- Pedigree Analysis for X-Linked Recessive Traits
- Y-Linked Inheritance Involves Transmission from Male to Male
- Mitochondrial Genes Are Transmitted from Mother to Offspring
- Pedigree Analysis and Variations in Gene Expression
- Genes on the Same Chromosome Are Linked
- Chapter 5. Polygenes and Multifactorial Inheritance
- Some Traits Are Controlled by Two or More Genes
- Polygenes and Variations in Phenotype
- Polygenes and the Environment: Multifactorial Traits
- Heritablilty Measures the Genetic Contribution to Phenotypic Variation
- Twin Studies and Multifactorial Traits
- A Survey of Some Multifactorial Traits
- Chapter 6. Cytogenetics: Karyotypes and Chromosome Aberrations
- The Human Chromosome Set
- Analyzing Chromosomes and Karyotypes
- Variations in Chromosomal Number
- What Are the Risks for Autosomal Trisomy?
- Aneuploidy of the Sex Chromosomes
- Structural Alterations within Chromosomes
- What Are Some Consequences of Aneuploidy?
- Other Forms of Chromosomal Abnormalities
- Chapter 7. Development and Sex Determination
- A Survey of Human Development: Fertilization to Birth
- Teratogens Are a Risk to the Developing Fetus
- Controlling Reproduction: Contraception and Assisted Reproductive Technologies (Art)
- How Is Sex Determined?
- Defining Sex in Stages: Chromosomes, Gonads, and Hormones
- Mutations Can Uncouple Chromsomal Sex from Phenotypic Sex
- Equalizing X Chromosomes in Males and Females
- Sex-Influenced and Sex-Limited Traits
- Chapter 8. DNA Structure and Chromosomal Organization
- DNA Carries Genetic Information
- Watson, Crick, and the Structure of DNA
- DNA Is a Double Helix
- RNA Is a Single-Stranded Nucleic Acid
- From DNA Molecules to Chromosomes
- DNA Replication Depends on Complementary Base Pairing
- Chapter 9. Gene Expression: How Proteins Are Made
- The Link Between Genes and Proteins
- Genetic Information Is Stored in DNA
- The Genetic Code: The Key to Life
- Tracing the Flow of Genetic Information from Nucleus to Cytoplasm
- Translation Requires the Interaction of Several Components
- Converting Polypeptides into Proteins
- Protein Structure and Function Are Related
- Chapter 10. From Proteins to Phenotypes
- Proteins Are the Link Between Genes and the Phenotype
- Enzymes and Metabolic Pathways
- Phenylketonuria: A Mutation That Affects an Enzyme
- Other Metabolic Diseases in the Phenylalanine Pathway
- Genes and Enzymes of Carbohydrate Metabolism
- Mutations in Receptor Proteins
- Mutations That Affect Transport Proteins
- Pharmacogenetics
- Ecogenetics
- Chapter 11. Mutation: The Source of Genetic Variation
- Mutations Are Heritable Changes
- Mutations Can Be Detected in Several Ways
- Measuring Mutation Rates
- Environmental Factors Influence Mutation Rates
- Mutation at the Molecular Level: DNA as a Target
- Mutations and DNA Damage Can Be Repaired
- Mutation, Genotypes, and Phenotypes
- Mutations Can Cause a Range of Phenotypes
- Genomic Imprinting Is a Reversible Alteration of the Genome
- Chapter 12. An Introduction to Cloning and Recombinant DNA
- What Are Clones?
- Cloning Genes Is a Multistep Process
- Cloned Libraries
- Finding a Specific Clone in a Library
- A Revolution in Cloning: The Polymerase Chain Reaction
- Analyzing Cloned Sequences
- Chapter 13. Biotechnology and Genomics
- Recombinant DNA Techniques Have Revolutionized Human Gene Mapping
- DNA Fingerprinting
- The Human Genome Project Is an International Effort
- Gene Transfer Technology Has Many Applications
- Ethical Questions About Cloning and Recombinant DNA
- Chapter 14. Genes and Cancer
- Cancers Are Malignant Tumors
- Mutations in Specific Genes Can Predispose to Cancer
- Tumor Suppressor Genes, Oncogenes, and the Cell Cycle
- Oncogenes and Cancer
- A Genetic Model for Cancer: Colon Cancer
- Chromosome Changes and Cancer
- Cancer and the Environment
- Chapter 15. Genetics of the Immune System
- The Immune System Defends the Body Against Infection
- The Inflammatory Response Is a General Reaction
- The Immune Response Is a Specific Defense Against Infection
- Blood Types Are Determined by Cell-Surface Antigens
- Organ Transplants Must Be Immunologically Matched
- Disorders of the Immune System
- Chapter 16. Genetics of Behavior
- Models, Methods, and Phenotypes in Studying Behavior
- Animal Models: The Search for Behavior Genes
- Single Genes Affect the Nervous System and Behavior
- Single Genes Control Aggressive Behavior and Brain Metabolism
- The Genetics of Mood Disorders and Schizophrenia
- Genetics and Social Behavior
- Summing up: The Current Status of Human Behavior Genetics
- Chapter 17. Genes in Populations
- The Population as a Genetic Reservoir
- How Can We Measure Allele Frequencies in Populations
- The Hardy-Weinberg Law: Measuring Allele and Genotype Frequencies
- Using the Hardy-Weinberg Law in Human Genetics
- Population Genetics Can Help Determine the Age and Origin of Human Genetic Diseases
- Chapter 18. Human Diversity and Evolution
- Measuring Genetic Diversity in Human Populations
- Natural Selection Affects the Frequency of Genetic Disorders
- Human Activity Can Change Allele Frequencies
- Genetic Variation in Human Populations
- What Are Races?
- Primate Evolution and Human Origins
- The Appearance and Spread of Homo Sapiens
- Chapter 19. Genetic Testing, Gene Therapy, and Counseling
- Genetic Testing and Genetic Screening
- Prenatal and Presymptomatic Genetic Testing
- Prenatal Testing for Genetic Disorders
- Presymptomatic Testing for Genetic Disorders
- Gene Therapy Promises to Correct Many Disorders
- Genetic Counseling
- Appendix A. Probability
- Appendix B. Answers to Selected Questions and Problems
- Glossary
- Credits
- Index
