HIV and the pathogenesis of AIDS /

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Bibliographic Details
Author / Creator:Levy, Jay A.
Edition:2nd ed.
Imprint:Washington, D.C. : ASM Press, c1998.
Description:xxii, 588 p. : ill. (some col.), maps ; 26 cm.
Language:English
Subject:
Format: Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/2906207
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ISBN:1555811221
Notes:Includes bibliographical references (p. 405-578) and index.
Table of Contents:
  • Discovery and Origin of HIV
  • Discovery of the AIDS Virus
  • The HIV Virion
  • Origin of HIV
  • Features of HIV Transmission
  • HIV in Blood
  • HIV in Genital Fluids
  • HIV in Saliva and Other Body Fluids
  • HIV Transmission by Blood and Blood Products
  • Sexual Transmission of HIV
  • Maternal-Child Transmission of HIV
  • Steps Involved in HIV: Cell Interaction and Virus EntryCD4 Receptor
  • Post-Binding Steps in Virus Entry
  • Virus: Cell Fusion
  • Other Possible Virus: Cell Surface Interactions Involved in Entry
  • Down-modulation of the CD4 Protein
  • Presence of other Cellular Receptors: Infection of Cells lacking CD4 Expression
  • Cell to Cell Transfer of HIV
  • Overview of early steps in HIV Infection
  • Other potential mechanisms involved in HIV entry into cells
  • Recombination
  • Acute HIV Infection and Cells Susceptible to HIV Infection
  • Acute HIV Infection
  • Cells and Tissues infected by HIV
  • The Number of CD4 and Lymphocytes infected by HIV
  • Interference and Superinfection
  • Intracellular Control of HIV Replication
  • Early intracellular events in HIV Infection
  • Differences in Virus production: Role of intracellular factors
  • Effect of other viruses on HIV Replication
  • Virus infection of Quiescent Cells
  • Latency
  • Cytopathic Properties of HIV
  • HIV Induction of Cell Fusion
  • Viral extrachromosomal DNA accumulation and cell death
  • Toxicity of the Virus and Viral Proteins
  • Apoptosis
  • Role of Superantigens
  • Heterogeneity of HIV and its Relation to PathogenesisHIV-2
  • Cellular host range differences among HIV-1 strains
  • Modulation of CD4 Protein Expression
  • Cytopathology
  • Latency
  • Molecular features
  • Serologic properties
  • Sensitivity to cell-mediated immune responses
  • Relation of HIV Heeterogeneity to Pathogenesis
  • Viral Regions Determining Biologic Features of HIV-1Envelope region and cell Tropism
  • Regulatory proteins and virus replication
  • Envelope region and cytopathicity, CD4 Modulation, and sCD4 Neutralization
  • Conclusions
  • Effect of HIV on Different tissues and Organ Systems in the Host
  • Hematopoietic System: Immune Function
  • Central nervous system
  • Gastrointestinal system
  • Effect of HIV on the function of other organ systems
  • Humoral Immune Responses to HIV Infection
  • Detection of Anti-HIV Antibodies
  • Neutralizing antibodies
  • Enhancing antibodies
  • Antibody-directed Cellular Cytotoxicity and Antibody-dependent Cytotoxicity
  • Complement fixing antiviral antibodies
  • Complement
  • Autoimmunity
  • Cell-Mediated Immune Responses in HIV Infection
  • General observations
  • Cytotoxic NK Cells
  • CD4 and Cell Function
  • Cytotoxic CD8 and Cells
  • CD8 and Cell suppressing activity
  • Cell-mediated antiviral immune responses in uninfected HIV-exposed high-risk individuals
  • Antiviral responses at Mucosal surfaces
  • HIV Infection and Development of Cancer
  • Introduction
  • Kaposi's Sarcoma
  • B Cell lymphomas
  • Anal Carcinoma
  • Cervical Carcinoma
  • Other Lymphomas
  • Summary
  • Overall Features of HIV Pathogenesis: Prognosis for Long-term Survival
  • Co-factors in HIV Infection and disease progression
  • Features of HIV Pathogenesis
  • Prognosis
  • Difference in clinical outcomes of infected individuals
  • Factors involved in long-term survival
  • High-risk exposed Seronegative individuals
  • Conclusions: Viral and Immunologic features of HIV Pathogenesis
  • Antiviral Therapies
  • Anti-HIV Therapies
  • Effect of Aniretroviral therapy on virus present in other tissues
  • Immunologic effects of antiretroviral therapy
  • Immune based therapies
  • Immune restoration
  • Post-infection immunization
  • Passive immunotherapy and use of antibody-based approaches
  • Vaccine Development
  • Introduction
  • Inactivated and attenuated viruses
  • Vaccines using purified Enveloped gp120 alone or in association with an Expression Vector
  • Viral cores as vaccines
  • Viral DNA inoculation
  • Cytokine enhancement
  • Induction of Mucosal immunity
  • Human vaccine trials
  • Other anti-HIV prevention approaches