HIV and the pathogenesis of AIDS /
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| Author / Creator: | Levy, Jay A. |
|---|---|
| Edition: | 2nd ed. |
| Imprint: | Washington, D.C. : ASM Press, c1998. |
| Description: | xxii, 588 p. : ill. (some col.), maps ; 26 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/2906207 |
Table of Contents:
- Discovery and Origin of HIV
- Discovery of the AIDS Virus
- The HIV Virion
- Origin of HIV
- Features of HIV Transmission
- HIV in Blood
- HIV in Genital Fluids
- HIV in Saliva and Other Body Fluids
- HIV Transmission by Blood and Blood Products
- Sexual Transmission of HIV
- Maternal-Child Transmission of HIV
- Steps Involved in HIV: Cell Interaction and Virus EntryCD4 Receptor
- Post-Binding Steps in Virus Entry
- Virus: Cell Fusion
- Other Possible Virus: Cell Surface Interactions Involved in Entry
- Down-modulation of the CD4 Protein
- Presence of other Cellular Receptors: Infection of Cells lacking CD4 Expression
- Cell to Cell Transfer of HIV
- Overview of early steps in HIV Infection
- Other potential mechanisms involved in HIV entry into cells
- Recombination
- Acute HIV Infection and Cells Susceptible to HIV Infection
- Acute HIV Infection
- Cells and Tissues infected by HIV
- The Number of CD4 and Lymphocytes infected by HIV
- Interference and Superinfection
- Intracellular Control of HIV Replication
- Early intracellular events in HIV Infection
- Differences in Virus production: Role of intracellular factors
- Effect of other viruses on HIV Replication
- Virus infection of Quiescent Cells
- Latency
- Cytopathic Properties of HIV
- HIV Induction of Cell Fusion
- Viral extrachromosomal DNA accumulation and cell death
- Toxicity of the Virus and Viral Proteins
- Apoptosis
- Role of Superantigens
- Heterogeneity of HIV and its Relation to PathogenesisHIV-2
- Cellular host range differences among HIV-1 strains
- Modulation of CD4 Protein Expression
- Cytopathology
- Latency
- Molecular features
- Serologic properties
- Sensitivity to cell-mediated immune responses
- Relation of HIV Heeterogeneity to Pathogenesis
- Viral Regions Determining Biologic Features of HIV-1Envelope region and cell Tropism
- Regulatory proteins and virus replication
- Envelope region and cytopathicity, CD4 Modulation, and sCD4 Neutralization
- Conclusions
- Effect of HIV on Different tissues and Organ Systems in the Host
- Hematopoietic System: Immune Function
- Central nervous system
- Gastrointestinal system
- Effect of HIV on the function of other organ systems
- Humoral Immune Responses to HIV Infection
- Detection of Anti-HIV Antibodies
- Neutralizing antibodies
- Enhancing antibodies
- Antibody-directed Cellular Cytotoxicity and Antibody-dependent Cytotoxicity
- Complement fixing antiviral antibodies
- Complement
- Autoimmunity
- Cell-Mediated Immune Responses in HIV Infection
- General observations
- Cytotoxic NK Cells
- CD4 and Cell Function
- Cytotoxic CD8 and Cells
- CD8 and Cell suppressing activity
- Cell-mediated antiviral immune responses in uninfected HIV-exposed high-risk individuals
- Antiviral responses at Mucosal surfaces
- HIV Infection and Development of Cancer
- Introduction
- Kaposi's Sarcoma
- B Cell lymphomas
- Anal Carcinoma
- Cervical Carcinoma
- Other Lymphomas
- Summary
- Overall Features of HIV Pathogenesis: Prognosis for Long-term Survival
- Co-factors in HIV Infection and disease progression
- Features of HIV Pathogenesis
- Prognosis
- Difference in clinical outcomes of infected individuals
- Factors involved in long-term survival
- High-risk exposed Seronegative individuals
- Conclusions: Viral and Immunologic features of HIV Pathogenesis
- Antiviral Therapies
- Anti-HIV Therapies
- Effect of Aniretroviral therapy on virus present in other tissues
- Immunologic effects of antiretroviral therapy
- Immune based therapies
- Immune restoration
- Post-infection immunization
- Passive immunotherapy and use of antibody-based approaches
- Vaccine Development
- Introduction
- Inactivated and attenuated viruses
- Vaccines using purified Enveloped gp120 alone or in association with an Expression Vector
- Viral cores as vaccines
- Viral DNA inoculation
- Cytokine enhancement
- Induction of Mucosal immunity
- Human vaccine trials
- Other anti-HIV prevention approaches
