Basic & clinical endocrinology /
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| Edition: | 5th ed. |
|---|---|
| Imprint: | Stamford, Conn. : Appleton & Lange, c1997. |
| Description: | xv, 823 p. : ill. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/3158754 |
Table of Contents:
- Authors
- Preface
- 1.. Introduction to Endocrinology
- The Endocrine System
- Hormones: Endocrine, Paracrine, & Autocrine Actions
- Chemical Composition of Hormones
- Relationships between Hormones & Other Signaling Molecules
- Neurotransmitters & Hormones
- Vitamins & Hormones
- Oncogenes & Hormones
- The Immune System & Hormones
- Eicosanoids: Prostaglandins & Related Compounds
- Mechanisms of Hormone Action
- Hormone Receptors
- Hormone Effects on Receptor Activity
- Classes of Hormone Action
- Classification of Hormone Action by Receptor Type
- Classification of Hormone Action by Ligand Type
- Mechanisms of Ligand Action
- Regulation of Hormone Responsiveness
- Hormone Responses Can Be Self-Limiting
- Different Signals Influence Hormone Responsiveness
- Modulation of Hormone Levels
- Hormone Synthesis
- Regulation of Hormone Production
- Hormone Transport in the Circulation
- Transport of Hormones across the Membrane
- Metabolism & Elimination of Hormones
- Recombinant DNA, Genomics, Proteomics, & Endocrinology
- Sequencing of the Human Genome
- Genomics & Patterns of Transcription
- Proteomics
- Molecular Basis of Genetic Endocrine Disease
- Evolution of the Endocrine System
- The Origins of Regulatory Chemicals & the Metabolic Code
- Evolution of Hormones & Receptors
- Evolution of Multiple Hormone Response Systems
- Evolution of Endocrine Glands
- Integrative Networks
- Endocrine & Nervous System Relationships: Neuroendocrinology
- Hypothalamic-Pituitary Relationships
- Endocrine Organs & Hormone Production
- Actions of Hormones
- Hormone Release
- Fetal Development
- Cell Growth & Cancer
- Hormonal Effects on Intermediary Metabolism
- Hormonal Effects on Mineral & Water Metabolism
- Hormonal Effects on Cardiovascular & Renal Function
- Hormonal Effects on Skeletal Function
- Hormonal Effects on Reproductive Function
- Hormonal Effects on the Immune System
- Hormonal Effects on the Central Nervous System
- Selective Modulation
- Disorders of the Endocrine System
- Endocrine Hypofunction
- Endocrine Hyperfunction
- Defects in Sensitivity to Hormones
- Syndromes of Hormone Excess Due to Administration of Exogenous Hormone
- Nonendocrine Problems Associated with Endocrine Disease
- Approach to the Patient with Endocrine Disease
- Evidence-Based Endocrinology
- History & Physical Examination
- Laboratory Studies
- Screening for Endocrine Diseases
- Clinical Interpretation of Laboratory Tests
- Treatment of Endocrine Diseases
- Uses of Hormones & Selective Modulators in Therapy of Nonendocrine Disease
- 2.. Hormone Synthesis & Release
- Compartmentation of Eukaryotic Cells in Relation to Hormone Synthesis & Release
- Overview of Hormone Biosynthesis
- Membrane Vesicle-Mediated Hormone Export
- Hormone Export Not Mediated by Membrane Vesicles
- Metabolism, Transport, Elimination, & Regulation of Hormones
- 3.. Mechanisms of Hormone Action
- Receptors
- Neurotransmitter & Peptide Hormone Receptors
- G Protein-Coupled Receptors
- G Protein Transducers
- G Protein Disorders
- Effectors
- G Protein-Coupled Receptors & Human Disease
- Growth Factor Receptors
- Cytokine Receptors
- Guanylyl Cyclase-Linked Receptors
- Nuclear Action of Peptide Hormones
- Nuclear Receptors
- Steroid Receptor Family
- Thyroid Receptor Family
- Nongenomic Effects of the Steroid Hormones
- Steroid & Thyroid Hormone Receptor Resistance Syndromes
- 4.. Endocrine Autoimmunity
- Basic Immune Components & Mechanisms
- Immune Recognition & Response
- Tolerance
- Autoimmunity Is Multifactorial
- Genetic Factors in Autoimmunity
- Environmental Factors in Autoimmunity
- Single Gland Autoimmune Syndromes
- Autoimmune Aspects of Thyroid Disease
- Autoimmune Aspects of Type 1 Diabetes
- Autoimmune Aspects of Other Endocrinopathies
- Autoimmune Polyglandular Syndromes
- Autoimmune Polyglandular Syndrome I (APS-I)
- Autoimmune Polyglandular Syndrome II (APS-II)
- Management of Autoimmune Polyglandular Syndromes
- 5.. Hypothalamus & Pituitary Gland
- Hypothalamic Hormones
- Anterior Pituitary Hormones
- ACTH & Related Peptides
- Growth Hormone
- Prolactin
- Thyrotropin
- Gonadotropins: Luteinizing Hormone, Follicle-Stimulating Hormone
- Endocrinologic Evaluation of the Hypothalamic-Pituitary Axis
- Evaluation of ACTH
- Evaluation of Growth Hormone
- Evaluation of Prolactin
- Evaluation of TSH
- Evaluation of LH & FSH
- Problems in Evaluation of the Hypothalamic-Pituitary Axis
- Effects of Pharmacologic Agents on Hypothalamic-Pituitary Function
- Endocrine Tests of Hypothalamic-Pituitary Function
- Neuroradiologic Evaluation
- Pituitary & Hypothalamic Disorders
- Empty Sella Syndrome
- Hypothalamic Dysfunction
- Hypopituitarism
- Pituitary Adenomas
- Posterior Pituitary
- Antidiuretic Hormone (ADH; Vasopressin)
- Oxytocin
- Control of Water Balance
- Diabetes Insipidus
- Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)
- 6.. Growth
- Normal Growth
- Intrauterine Growth
- The Placenta
- Classic Hormones of Growth & Fetal Growth
- Growth Factors & Oncogenes in Fetal Growth
- Insulin-Like Growth Factors, Receptors, & Binding Proteins
- Insulin
- Epidermal Growth Factor
- Fetal Origins of Adult Disease
- Postnatal Growth
- Measurement of Growth
- Skeletal (Bone) Age
- Disorders of Growth
- Short Stature Due to Nonendocrine Causes
- Short Stature Due to Endocrine Disorders
- The Diagnosis of Short Stature
- Tall Stature Due to Nonendocrine Causes
- Beckwith-Wiedemann Syndrome
- Tall Stature Due to Endocrine Disorders
- 7.. The Thyroid Gland
- Anatomy & Histology
- Physiology
- Structure of Thyroid Hormones
- Iodine Metabolism
- Thyroid Hormone Synthesis & Secretion
- Abnormalities in Thyroid Hormone Synthesis & Release
- Thyroid Hormone Transport
- Metabolism of Thyroid Hormones
- Control of Thyroid Function
- The Action of Thyroid Hormones
- Physiologic Changes in Thyroid Function
- Thyroid Autoimmunity
- Tests of Thyroid Function
- Tests of Thyroid Hormones in Blood
- Evaluation of the Hypothalamic-Pituitary-Thyroid Axis
- Iodine Metabolism & Biosynthetic Activity
- Thyroid Imaging
- Thyroid Ultrasonography or Magnetic Resonance Imaging
- Thyroid Biopsy
- Effects of Thyroid Hormones on Peripheral Tissues
- Measurement of Thyroid Autoantibodies
- Summary: Clinical Use of Thyroid Function Tests
- Disorders of the Thyroid
- Hypothyroidism
- Hyperthyroidism & Thyrotoxicosis
- Thyroid Hormone Resistance Syndromes
- Nontoxic Goiter
- Thyroiditis
- Effects of Ionizing Radiation on the Thyroid Gland
- Thyroid Nodules & Thyroid Cancer
- 8.. Metabolic Bone Disease
- Cellular & Extracellular Calcium Metabolism
- Parathyroid Hormone
- Calcitonin
- Vitamin D
- Integrated Control of Mineral Homeostasis
- Medullary Thyroid Carcinoma
- Hypercalcemia
- Disorders Causing Hypercalcemia
- Treatment of Hypercalcemia
- Hypocalcemia
- Causes of Hypocalcemia
- Treatment of Hypocalcemia
- Bone Anatomy & Remodeling
- Functions of Bone
- Structure of Bone
- Bone Remodeling
- Osteoporosis
- Treatment of Osteoporosis
- Nonpharmacologic Aspects of Osteoporosis Management
- Glucocorticoid-Induced Osteoporosis
- Osteomalacia & Rickets
- Nephrotic Syndrome
- Hepatic Osteodystrophy
- Drug-Induced Osteomalacia
- Hypophosphatemic Disorders
- Calcium Deficiency
- Primary Disorders of the Bone Matrix
- Inhibitors of Mineralization
- Paget's Disease of Bone (Osteitis Deformans)
- Renal Osteodystrophy
- 9.. Glucocorticoids & Adrenal Androgens
- Embryology & Anatomy
- Biosynthesis of Cortisol & Adrenal Androgens
- Circulation of Cortisol & Adrenal Androgens
- Metabolism of Cortisol & Adrenal Androgens
- Biologic Effects of Adrenal Steroids
- Glucocorticoids
- Adrenal Androgens
- Laboratory Evaluation
- Disorders of Adrenocortical Insufficiency
- Primary Adrenocortical Insufficiency (Addison's Disease)
- Secondary Adrenocortical Insufficiency
- Diagnosis of Adrenocortical Insufficiency
- Treatment of Adrenocortical Insufficiency
- Prognosis of Adrenocortical Insufficiency
- Cushing's Syndrome
- Hirsutism & Virilism
- Incidental Adrenal Mass
- Glucocorticoid Therapy for Nonendocrine Disorders
- 10.. Endocrine Hypertension
- Hypertension of Adrenal Origin
- Synthesis, Metabolism, & Action of Mineralocorticoid Hormones
- Pathogenesis of Mineralocorticoid Hypertension
- Aldosterone & the Heart
- Primary Aldosteronism
- Syndromes Due to Excess Deoxycorticosterone Production
- Cushing's Syndrome
- Pseudohyperaldosteronism
- Type II Pseudohypoaldosteronism (Arnold-Healy-Gordon Syndrome)
- Hypertension of Renal Origin
- The Renin-Angiotensin System
- The Renin-Angiotensin System & Hypertension
- Other Hormone Systems & Hypertension
- Insulin
- Natriuretic Peptides
- Endothelium-Derived Relaxing Factor
- Endothelin
- Kallikrein-Kinin System
- Other Hormones & Autacoids
- Sympathetic Nervous System
- 11.. Adrenal Medulla
- History
- Anatomy
- Hormones of the Adrenal Medulla
- Catecholamines
- Other Hormones
- Disorders of Adrenal Medullary Function
- Adrenal Medullary Hypofunction
- Adrenal Medullary Hyperfunction
- Pheochromocytoma
- 12.. Testes
- Anatomy & Structure-Function Relationships
- Testes
- Accessory Structures
- Physiology of the Male Reproductive System
- Gonadal Steroids
- Control of Testicular Function
- Evaluation of Male Gonadal Function
- Clinical Evaluation
- Laboratory Tests of Testicular Function
- Pharmacology of Drugs Used to Treat Male Gonadal Disorders
- Androgens
- Gonadotropins
- Gonadotropin-Releasing Hormone
- Clinical Male Gonadal Disorders
- Klinefelter's Syndrome (XXY Seminiferous Tubule Dysgenesis)
- Bilateral Anorchia (Vanishing Testes Syndrome)
- Cryptorchidism
- Noonan's Syndrome (Male Turner's Syndrome)
- Myotonic Dystrophy
- Adult Leydig Cell Failure (Andropause)
- Male Infertility
- Erectile Dysfunction (Impotence)
- Gynecomastia
- Testicular Tumors
- 13.. Female Reproductive Endocrinology & Infertility
- Embryology & Anatomy
- Ovarian Steroidogenesis
- Physiology of the Menstrual Cycle
- Menstrual Disturbances
- Hypothalamic Amenorrhea
- Pituitary Amenorrhea
- Ovarian Amenorrhea
- Adrenal Causes of Amenorrhea
- Outflow Tract Disorders
- Menopause
- Oocyte Depletion
- Endocrine System Changes with Aging
- Menopausal Consequences
- Infertility
- Diagnosis of Infertility
- Management of the Infertile Couple
- Contraception
- Oral Contraceptives
- Contraception: Long-Acting Contraceptives
- Emergency Contraception
- 14.. Abnormalities of Sexual Determination & Differentiation
- Normal Sex Differentiation
- Testicular & Ovarian Differentiation
- Psychosexual Differentiation
- Abnormal Sex Differentiation
- Seminiferous Tubule Dysgenesis: Chromatin-Positive Klinefelter's Syndrome & Its Variants
- Syndrome of Gonadal Dysgenesis: Turner's Syndrome & Its Variants
- True Hermaphroditism
- Female Pseudohermaphroditism
- P450 Aromatase Deficiency
- Maternal Androgens & Progestogens
- Male Pseudohermaphroditism
- Unclassified Forms of Abnormal Sexual Development in Males
- Unclassified Forms of Abnormal Sexual Development in Females
- Management of Patients with Intersex Problems
- 15.. Puberty
- Physiology of Puberty
- Delayed Puberty or Absent Puberty (Sexual Infantilism)
- Precocious Puberty (Sexual Precocity)
- 16.. The Endocrinology of Pregnancy
- Conception & Implantation
- Fetal-Placental-Decidual Unit
- Polypeptide Hormones
- Steroid Hormones
- Maternal Adaptation to Pregnancy
- Fetal Endocrinology
- Endocrine Control of Parturition
- Endocrinology of the Puerperium
- Endocrine Disorders & Pregnancy
- Pituitary Disorders
- Pregnancy & Breast Cancer
- Hypertensive Disorders of Pregnancy
- Hyperthyroidism in Pregnancy
- Hypothyroidism in Pregnancy
- 17.. Pancreatic Hormones & Diabetes Mellitus
- The Endocrine Pancreas
- Anatomy & Histology
- Hormones of the Endocrine Pancreas
- Diabetes Mellitus
- Classification
- Type 1 Diabetes Mellitus
- Type 2 Diabetes
- Other Specific Types of Diabetes
- Clinical Features of Diabetes Mellitus
- Type 1 Diabetes
- Type 2 Diabetes
- Urinalysis
- Blood Glucose Testing
- Serum Ketone Determinations
- Glycated Hemoglobin Assays
- Lipoproteins in Diabetes
- Diagnosis of Diabetes Mellitus
- Oral Glucose Tolerance Test
- Insulin Levels
- Intravenous Glucose Tolerance Test
- Treatment of Diabetes Mellitus
- Diet
- Oral Agents for the Treatment of Hyperglycemia
- Insulin
- Steps in the Management of the Diabetic Patient
- Acute Complications of Diabetes Mellitus
- Hypoglycemia
- Coma
- Chronic Complications of Diabetes Mellitus
- Specific Chronic Complications of Diabetes Mellitus
- Surgery in the Diabetic Patient
- Diabetics Regulated by Diet Alone
- Diabetics Taking Oral Hypoglycemic Agents
- Diabetics Taking Insulin
- Diabetes Mellitus & Pregnancy (by John L. Kitzmiller, MD)
- Prognosis for Patients with Diabetes Mellitus
- 18.. Hypoglycemic Disorders
- Pathophysiology of the Counterregulatory Response to Neuroglycopenia
- Classification of Hypoglycemic Disorders
- Clinical Presentation of Hypoglycemia
- Specific Hypoglycemic Disorders
- Symptomatic Fasting Hypoglycemia with Hyperinsulinism
- Symptomatic Fasting Hypoglycemia without Hyperinsulinism
- Nonfasting Hypoglycemia (Reactive Hypoglycemia)
- 19.. Disorders of Lipoprotein Metabolism
- Atherosclerosis
- Overview of Lipid Transport
- Differentiation of Disorders of Lipoprotein Metabolism
- Clinical Descriptions of Primary & Secondary Disorders of Lipoprotein Metabolism
- The Hypertriglyceridemias
- Primary Hypertriglyceridemia
- Secondary Hypertriglyceridemia
- The Primary Hypercholesterolemias
- Familial Hypercholesterolemia
- Familial Combined Hyperlipidemia
- LP(a) Hyperlipoproteinemia
- Familial Ligand-Defective APO B
- Cholesterol 7-[alpha]-Hydroxylase Deficiency
- Secondary Hypercholesterolemia
- Hypothyroidism
- Nephrosis
- Immunoglobulin Disorders
- Anorexia Nervosa
- Cholestasis
- The Primary Hypolipidemias
- Primary Hypolipidemia Due to Deficiency of High-Density Lipoproteins
- Primary Hypolipidemia Due to Deficiency of APO B-Containing Lipoproteins
- Secondary Hypolipidemia
- Other Disorders of Lipoprotein Metabolism
- The Lipodystrophies
- Rare Disorders
- Treatment of Hyperlipidemia
- Dietary Factors in the Management of Lipoprotein Disorders
- Drugs Used in Treatment of Hyperlipoproteinemia
- Bile Acid Sequestrants
- Niacin (Nicotinic Acid)
- Fibric Acid Derivatives
- HMG-CoA Reductase Inhibitors
- Combined Drug Therapy
- Possible Untoward Consequences of Lipid-Lowering Therapy
- 20.. Obesity & Overweight
- Controversies & Uncertainties Regarding the Pathogenesis of Obesity
- Survey of Treatment Approaches & Their Efficacy
- Dietary Therapies
- Surgical Treatment of Obesity
- Pharmacologic Therapies
- Other Conditions Affected by Treatment of Obesity or Overweight
- Type 2 Diabetes Mellitus
- Hyperlipidemia
- Polycystic Ovarian Syndrome
- Hypertension
- Gallstones
- Osteoarthritis & Other Weight-Sensitive States
- A Systematic Approach to the Treatment of Obesity
- 21.. Humoral Manifestations of Malignancy
- Ectopic Hormone & Receptor Syndromes
- Hypercalcemia of Malignancy
- Ectopic Cushing's Syndrome
- Syndrome of Inappropriate ADH (SIADH) Secretion
- Non-Islet Cell Tumors & Hypoglycemia
- Other Hormones Secreted by Tumors
- Oncogenic Osteomalacia
- Gut Hormones
- 22.. Multiple Endocrine Neoplasia
- Multiple Endocrine Neoplasia Type 1 (MEN 1)
- Multiple Endocrine Neoplasia Type 2 (MEN 2)
- Other Disorders Characterized by Multiple Endocrine Organ Involvement
- 23.. Geriatric Endocrinology
- Thyroid Function & Disease
- Disorders of the Thyroid Gland
- Carbohydrate Intolerance & Diabetes Mellitus
- Aging & the Physiology of Carbohydrate Intolerance
- Diabetes Mellitus
- Nonketotic Hyperosmolar Coma
- Osteoporosis & Calcium Homeostasis
- Osteoporosis
- Hyperparathyroidism
- Changes in Water Balance
- Hypernatremia
- Hyponatremia
- Hyporeninemic Hypoaldosteronism
- Glucocorticoids & Stress
- Disorders of the Hypothalamic-Pituitary-Adrenal Axis
- Changes in Reproductive Function in Men
- Benign Prostatic Hyperplasia
- 24.. Endocrine Emergencies
- Myxedema Coma
- Thyroid Storm
- Thyrotoxic Periodic Paralysis
- Amiodarone Induced Thyrotoxicosis
- Acute Adrenal Insufficiency
- Pituitary Apoplexy
- Diabetic Ketoacidosis
- Nonketotic Hyperosmolar Coma
- Hypercalcemic Crisis
- Acute Hypocalcemia
- Hyponatremia
- Diabetes Insipidus
- 25.. AIDS Endocrinopathies
- Thyroid Disorders
- Adrenal Disorders
- Bone & Mineral Disorders
- Gonadal Disorders
- Pituitary Disorders
- Pancreatic Disorders
- Lipid Disorders
- Conclusion
- 26.. Endocrine Surgery
- Introduction
- The Thyroid Gland
- Developmental Thyroid Abnormalities
- Hyperthyroidism
- Thyroiditis
- Nodular Goiter
- Thyroid Nodules
- Thyroid Cancer
- Conduct of Thyroidectomy
- The Parathyroid Gland
- Primary Hyperparathyroidism
- Persistent & Recurrent Primary Hyperparathyroidism
- Secondary Hyperparathyroidism
- Special Consideration: Familial Hyperparathyroidism
- Complications of Parathyroid Surgery
- The Adrenal (Suprarenal) Gland
- Primary Hyperaldosteronism
- Hypercortisolism
- Sex Steroid Excess
- Pheochromocytoma
- Adrenal Cortical Carcinoma
- Adrenal Incidentaloma
- Technique of Adrenalectomy
- The Endocrine Pancreas
- Insulinoma
- Gastrinoma (Zollinger-Ellison Syndrome)
- Vipoma (Verner-Morrison) Syndrome
- Glucagonoma
- Somatostatinoma
- Nonfunctioning Pancreatic Tumors
- Appendix. Normal Hormone Reference Ranges
- Index
