Molecular diagnostics : for the clinical laboratorian /
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| Imprint: | Totowa, N.J. : Humana Press, c1997. |
|---|---|
| Description: | x, 390 p. : ill. ; 26 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/3184109 |
Table of Contents:
- Dedication
- Foreword
- Preface
- Color Plates
- Contributors
- Value Added eBook Instructions
- Part I. Introduction
- 1. An Historical Perspective on the Clinical Diagnostic Laboratory
- Part II. Basic Molecular Biology
- 2. An Overview of Nucleic Acid Chemistry, Structure, and Function: The Foundations of Molecular Biology
- 3. Extraction of Nucleic Acids
- 4. Nucleic Acid Blotting Techniques: Theory and Practice
- 5. The Polymerase Chain Reaction
- 6. Bioinformatics: Computer-Based Approaches to Genetic Analysis
- Part III. Molecular Diagnostic Technologies
- 7. PCR-Based Methods for Mutation Detection
- 8. Alternative Methods for Amplified Nucleic Acid Testing
- 9. Electrophoretic Methods for Mutation Detection and DNA Sequencing
- 10. Single-Nucleotide Polymorphisms: Testing DNA Variation for Disease Association
- 11. Microarray Approaches to Gene Expression Analysis
- 12. Methods for Analysis of DNA Methylation
- Part IV. Other Clinical Diagnostic Technologies
- 13. Flow Cytometry
- 14. Medical Cytogenetics
- 15. Fluorescence In Situ Hybridization: A Major Milestone in Luminous Cytogenetics
- 16. Immunohistochemistry
- 17. Laser Capture Microdissection
- Part V. Quality Assurance in the Molecular Diagnostics Laboratory
- 18. Framework for Quality Assurance in Molecular Diagnostics
- 19. Verification of Molecular Assays
- 20. Standards and Standardization of Molecular Diagnostics
- 21. Laboratory-Developed Tests in Molecular Diagnostics
- Part VI. Applications of Molecular Diagnostics for Genetic Diseases
- 22. An Overview of Molecular Genetics
- 23. Genetic Basis of Neurologic and Neuromuscular Diseases
- 24. Molecular Mechanisms of Endocrine Disorders
- 25. Molecular Pathogenesis of Cardiovascular Disease
- 26. Molecular Diagnostics in Coagulation
- 27. Cystic Fibrosis
- 28. Prenatal Genotyping for Identification of Fetuses at Risk for Immune Cytopenic Disorders
- 29. Personalized Medicine
- Part VII. Applications of Molecular Diagnostics for Human Cancers
- 30. Molecular Pathogenesis of Human Cancer
- 31. Application of Molecular Diagnostics to Hereditary Nonpolyposis Colorectal Cancer
- 32. Molecular Genetic Applications to the Diagnosis of Lymphoma
- 33. Molecular Genetic Abnormalities in Acute and Chronic Leukemias
- Part VIII. Applications of Molecular Diagnostics for Infectious Diseases
- 34. Molecular Testing for Chlamydia trachomatis and Neisseria gonorrhoeae
- 35. Human Papillomavirus
- 36. Molecular Diagnosis for HIV-1
- 37. Hepatitis C
- 38. Cytomegalovirus
- Part IX. Applications of Molecular Diagnostics for Identity-Based Testing
- 39. HLA Typing Using Molecular Methods
- 40. Molecular Analysis for Forensic Casework and Parentage Testing
- 41. Molecular Assessment of Bone Marrow Transplant Engraftment
- 42. Use of DNA-Based Identity Testing for Specimen Identification
- Part X. Issues for the Clinical Molecular Pathology Laboratory
- 43. Genetic Counseling Considerations in Molecular Diagnosis
- 44. Ethical, Social, and Legal Issues Related to Molecular Genetic Testing
- Index
