TGFβ and cancer /
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| Author / Creator: | Benson, John R., 1959- |
|---|---|
| Imprint: | Austin, Tex. : R.G. Landes, c1998. |
| Description: | 171 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Medical intelligence unit |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/3694512 |
Table of Contents:
- 1.. Growth Factors and Carcinogenesis
- i). Introduction
- ii). Positive Growth Factors
- iii). Negative Growth Factors
- iv). Growth Factor Receptors
- v). Growth Factors and Regulation of Tumor Growth
- 2.. The TGF[beta] Family
- i). Introduction
- ii). Structure of the TGF[beta] Molecule
- iii). Mechanisms of Activation of TGF[beta]
- iv). TGF[beta] Receptors
- v). Intracellular Transduction Mechanisms
- vi). Control of TGF[beta] Gene Expression
- 3.. Biological Functions of TGF[beta]
- i). Introduction
- ii). Extracellular Matrix Effects
- iii). Cell Proliferation Effects
- iv). Angiogenesis
- v). Immunological Effects
- vi). Tumor Promotion/Progression
- vii). Metastasis
- viii). Conclusions and Future Directions
- 4.. Stromal-Epithelial Interactions
- i). Introduction
- ii). Stromal-Epithelial Interactions During Development
- iii). Stromal-Epithelial Interactions in Adult Tissues
- iv). Stromal-Epithelial Interactions and Malignancy
- v). Mechanisms of Stromal-Epithelial Interaction in Carcinogenesis
- 5.. TGF[beta]s in the Developing Organism
- i). Introduction
- ii). Evidence for a Role in Embryogenesis
- iii). Expression of TGF[beta] Isoforms in Embryonic and Developing Tissues
- iv). Role in Mammary Development
- v). TGF[beta] in the Developing Mammalian Mammary Gland
- vi). Role in Reproductive Function and Embryogenic Development
- vii). Implications and Conclusions
- 6.. TGF[beta] and Colonic Neoplasia
- i). Introduction to Colorectal Neoplasia
- ii). Growth Regulation In the Colorectum
- iii). Mechanisms of TGF[beta]1 Growth Regulation in the Colon
- iv). TGF[beta] Receptors and HNPCC
- v). TGF[beta]1 and the Regulation of Apoptosis in the Colon
- vi). TGF[beta] and Metastatic Competence
- vii). Future Applications, New Researches and Anticipated Developments
- 7.. Role of TGF[beta] in Carcinogenesis and Mediation of Therapeutic Response in Breast Cancer
- i). Introduction
- ii). Anti-Estrogens
- iii). Progestins
- iv). Retinoids
- v). Chemoprevention
- vi). TGF[beta] and Carcinogenesis
- vii). Prospects for Therapy
- 8.. TGFb and Cancer in Other Organs
- i). Introduction
- ii). Gastric Cancer
- iii). Lung Cancer
- iv). Prostate Cancer
