Human gene evolution /

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Bibliographic Details
Author / Creator:Cooper, David N. (David Neil), 1957-
Imprint:Oxford : Bios Scientific Publishers ; San Diego, CA : distributed exclusively throughout the United States by Academic Press, 1999.
Description:xvii, 490 p. : ill. ; 24 cm.
Language:English
Series:Human molecular genetics series
Subject:
Format: Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/4252663
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ISBN:0121878708
Notes:Includes bibliographical references and indexes.

MARC

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300 |a xvii, 490 p. :  |b ill. ;  |c 24 cm. 
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440 4 |a Human molecular genetics series 
504 |a Includes bibliographical references and indexes. 
505 0 0 |g Pt. 1.  |t Introduction and Overview.  |g 1.  |t Structure and function in the human genome.  |t Chromosome structure and function.  |t Gene organization and transcriptional regulation.  |t DNA methylation.  |t Repetitive sequence elements.  |t Genes, mutations and disease.  |g 2.  |t Evolution of the human genome.  |t Ancient genome duplications at the dawn of vertebrate evolution.  |t Mammalian genome evolution.  |t Primate evolution.  |t Sequencing the genomes of model organisms and humans --  |g Pt. 2.  |t Evolution of Gene Structure.  |g 3.  |t Introns, exons, and evolution.  |t Intron structure, function and evolution.  |t The evolution of alternative processing.  |t Exon structure and evolution.  |t Introns early or introns late?  |t Mechanisms of intron insertion and deletion.  |t Exon shuffling.  |t Pseudoexons.  |g 4.  |t Genes and gene families.  |t The origins of human genes.  |t Multigene families.  |t Convergent evolution.  |t Coevolution.  |g 5.  |t Promoters and transcription factors.  |t Promoters and enhancers.  |t Transcription factors.  |g 6.  |t Pseudogenes and their formation.  |t Pseudogene formation.  |t Gene loss/inactivation in primates --  |g Pt. 3.  |t Mutational Mechanisms in Evolution.  |g 7.  |t Single base-pair substitutions.  |t Single base-pair substitutions in evolution.  |t Mutations in pathology and evolution; two sides of the same coin.  |t The importance of evolutionary conservation in the study of pathological mutations at the protein level using human factor IX as a model.  |t Equilibrium of synonymous codon substitutions.  |t Single base-pair substitutions in gene regions.  |g 8.  |t Contractions and expansions in gene size and number.  |t Gross gene deletions in evolution.  |t Microdeletions in evolution.  |t Microinsertions in evolution.  |t Insertion of transposable elements in evolution.  |t Gross gene duplications in evolution.  |t Intragenic gene duplications in evolution.  |t Coding sequence expansion and contraction resulting from the introduction or removal of initiation and termination codons.  |t Minisatellites, microsatellites and telomeric repeats.  |t Expansion of unstable repeat sequences.  |g 9.  |t Gross gene rearrangements.  |t Inversions.  |t Translocations and transpositions.  |t Gene fusion.  |t Recombination.  |t Gene conversion.  |t Gene creation by retrotransposition.  |g 10.  |t Molecular reconstruction of ancient genes/proteins.  |t Molecular reconstruction and homology modelling of the catalytic domain of the common ancestor of the hemostatic vitamin K-dependent serine proteases.  |t Indices of Human Gene Symbols used in the text. 
650 0 |a Human genetics.  |0 http://id.loc.gov/authorities/subjects/sh85062875 
650 0 |a Molecular genetics.  |0 http://id.loc.gov/authorities/subjects/sh00006394 
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650 7 |a Molecular evolution.  |2 fast  |0 http://id.worldcat.org/fast/fst01024792 
650 7 |a Mutagenesis.  |2 fast  |0 http://id.worldcat.org/fast/fst01031137 
650 7 |a Transcription factors.  |2 fast  |0 http://id.worldcat.org/fast/fst01154564 
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