DNA alterations in cancer : genetic and epigenetic changes /
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| Imprint: | Natick, MA : Eaton Pub., c2000. |
|---|---|
| Description: | xvii, 508 p. : ill. ; 27 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4259038 |
Table of Contents:
- Section I.. Introduction
- 1. Introduction to Cancer Genes and Growth Control
- Section II.. Tumor Suppressor Genes and Cancer Modifier Loci
- 2. Rb and Other Pocket Proteins, Chromatin Remodeling, and Cancer
- 3. The Hedgehog/Patched Signaling Pathway: The Role of Tumor Suppressor Genes in Development
- 4. Structure-Function Relationship of the INK4 Family of Tumor Suppressors
- 5. The Role of Genetic Modifiers, Both Mutations and Polymorphisms, and Environmental Factors in Cancer Susceptibility
- Section III.. Activation of the Oncogenic Function of Proto-Oncogenes and Other Cancer-Promoting Genes by Mutation or Rearrangement
- 6. Multiple Roles for Deregulated MYC Expression in Oncogenesis
- 7. Misregulation of a Signal Transduction Pathway: The Role of Rel/NF-[kappa]B Transcription Factors in Oncogenesis
- 8. Fusion Oncoproteins Resulting from Chromosomal Translocations and Leukemogenesis
- 9. Dissecting the Genetics of the RET Proto-Oncogene: Paradigm for Molecular Medicine
- Section IV.. DNA Repair and Cancer
- 10. DNA Repair Pathways and Changes in Cancer
- 11. Mutagenesis and Tumor Development in DNA Mismatch Repair-Deficient Mice
- 12. LOH and Mitotic Recombination
- Section V.. Inherited Mutations Contributing to Oncogenesis
- 13. Cancer Susceptibility Genes: Germline Mutations and Polymorphisms Conferring High Risks of Neoplasia
- 14. ATM: At the Crossroads of DNA Damage Response, Cell-Cycle Control, Genome Stability, and Cancer
- 15. Molecular Basis of Predisposition to Colon Cancer
- 16. Inherited Susceptibility to Breast Cancer in Women: High-Penetrance and Low-Penetrance Genes
- Section VI.. DNA Methylation, Imprinting, and Cancer
- 17. DNA Hypomethylation and Cancer
- 18. Epigenetics and Loss of Gene Function in Cancer
- 19. Hypermethylator Phenotypes in Aging and Cancer
- 20. 5-Methylcytosine and Human Cancer Mutations: Lessons from p53
- 21. Genomic Imprinting and Human Neoplasia
- 22. DNA Methylation and Methyltransferases
- Section VII.. The Contribution of Karyotypic Instability to Cancer Formation and Tumor Progression
- 23. Chromosome and Karyotype Instability in Human Cancers and Cancer-Predisposing Syndromes
- 24. Clonal Evolution of Neoplastic Cell Populations: Lessons from Solid Tumor Cytogenetics
- 25. The Role of Fragile Sites in Gene Amplification and Genome Remodeling
- 26. p53 and the Development of Genomic Instability: Possible Role of Topoisomerase I Interaction
- Section VIII.. New Strategies for Cancer Therapies
- 27. Telomerase as a Potential Target for Anticancer Therapies
- 28. New p53-Based Strategies for Cancer Therapy
- 29. Therapeutic Resistance of erbB-2--Overexpressing Cancers and Strategies to Overcome This Resistance
- 30. The DNA Repair Protein O[superscript 6]-Alkylguanine-DNA Alkyltransferase as a Target for Cancer Chemotherapy
- 31. Acquired Drug Resistance Driven by Tumor Cell Genetic Instability: Circumvention by Direct-Acting Anti-Angiogenic Vascular Targeting Agents
