DNA alterations in cancer : genetic and epigenetic changes /

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Bibliographic Details
Imprint:Natick, MA : Eaton Pub., c2000.
Description:xvii, 508 p. : ill. ; 27 cm.
Language:English
Subject:
Format: Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/4259038
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Other authors / contributors:Ehrlich, Melanie, 1945-
ISBN:1881299198
Notes:Includes bibliographical references and index.
Table of Contents:
  • Section I.. Introduction
  • 1. Introduction to Cancer Genes and Growth Control
  • Section II.. Tumor Suppressor Genes and Cancer Modifier Loci
  • 2. Rb and Other Pocket Proteins, Chromatin Remodeling, and Cancer
  • 3. The Hedgehog/Patched Signaling Pathway: The Role of Tumor Suppressor Genes in Development
  • 4. Structure-Function Relationship of the INK4 Family of Tumor Suppressors
  • 5. The Role of Genetic Modifiers, Both Mutations and Polymorphisms, and Environmental Factors in Cancer Susceptibility
  • Section III.. Activation of the Oncogenic Function of Proto-Oncogenes and Other Cancer-Promoting Genes by Mutation or Rearrangement
  • 6. Multiple Roles for Deregulated MYC Expression in Oncogenesis
  • 7. Misregulation of a Signal Transduction Pathway: The Role of Rel/NF-[kappa]B Transcription Factors in Oncogenesis
  • 8. Fusion Oncoproteins Resulting from Chromosomal Translocations and Leukemogenesis
  • 9. Dissecting the Genetics of the RET Proto-Oncogene: Paradigm for Molecular Medicine
  • Section IV.. DNA Repair and Cancer
  • 10. DNA Repair Pathways and Changes in Cancer
  • 11. Mutagenesis and Tumor Development in DNA Mismatch Repair-Deficient Mice
  • 12. LOH and Mitotic Recombination
  • Section V.. Inherited Mutations Contributing to Oncogenesis
  • 13. Cancer Susceptibility Genes: Germline Mutations and Polymorphisms Conferring High Risks of Neoplasia
  • 14. ATM: At the Crossroads of DNA Damage Response, Cell-Cycle Control, Genome Stability, and Cancer
  • 15. Molecular Basis of Predisposition to Colon Cancer
  • 16. Inherited Susceptibility to Breast Cancer in Women: High-Penetrance and Low-Penetrance Genes
  • Section VI.. DNA Methylation, Imprinting, and Cancer
  • 17. DNA Hypomethylation and Cancer
  • 18. Epigenetics and Loss of Gene Function in Cancer
  • 19. Hypermethylator Phenotypes in Aging and Cancer
  • 20. 5-Methylcytosine and Human Cancer Mutations: Lessons from p53
  • 21. Genomic Imprinting and Human Neoplasia
  • 22. DNA Methylation and Methyltransferases
  • Section VII.. The Contribution of Karyotypic Instability to Cancer Formation and Tumor Progression
  • 23. Chromosome and Karyotype Instability in Human Cancers and Cancer-Predisposing Syndromes
  • 24. Clonal Evolution of Neoplastic Cell Populations: Lessons from Solid Tumor Cytogenetics
  • 25. The Role of Fragile Sites in Gene Amplification and Genome Remodeling
  • 26. p53 and the Development of Genomic Instability: Possible Role of Topoisomerase I Interaction
  • Section VIII.. New Strategies for Cancer Therapies
  • 27. Telomerase as a Potential Target for Anticancer Therapies
  • 28. New p53-Based Strategies for Cancer Therapy
  • 29. Therapeutic Resistance of erbB-2--Overexpressing Cancers and Strategies to Overcome This Resistance
  • 30. The DNA Repair Protein O[superscript 6]-Alkylguanine-DNA Alkyltransferase as a Target for Cancer Chemotherapy
  • 31. Acquired Drug Resistance Driven by Tumor Cell Genetic Instability: Circumvention by Direct-Acting Anti-Angiogenic Vascular Targeting Agents