The blood-brain barrier and drug delivery to the CNS /
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| Imprint: | New York : Dekker, ©2000. |
|---|---|
| Description: | x, 248 pages : illustrations ; 24 cm |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4352121 |
Table of Contents:
- Preface
- Contributors
- 1.. History and Physiology of the Blood-Brain Barrier in Relation to Delivery of Drugs to the Brain
- 2.. Physicochemical Factors that Influence Brain Uptake
- 3.. The Development of In Vitro Models for the Blood-Brain and Blood-CSF Barriers
- 4.. In Vitro Models of the Blood-Brain Barrier and Their Use in Drug Development
- 5.. The Application of Microdialysis Techniques to the Study of Drug Transport Across the Blood-Brain Barrier
- 6.. The Role of Brain Extracellular Fluid Production and Efflux Mechanisms in Drug Transport to the Brain
- 7.. The Relevance of P-Glycoprotein in Drug Transport to the Brain: The Use of Knockout Mice as a Model System
- 8.. Specific Mechanisms for Transporting Drugs Into Brain
- 9.. Drug Metabolism in the Brain: Benefits and Risks
- 10.. Targeting Macromolecules to the Central Nervous System
- 11.. Using Nanoparticles to Target Drugs to the Central Nervous System
- 12.. Basic CNS Drug Transport and Binding Kinetics In Vivo
- Index
