Biocatalysis and biodegradation : microbial transformation of organic compounds /
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| Author / Creator: | Wackett, Lawrence Philip. |
|---|---|
| Imprint: | Washington, D.C. : ASM Press, c2001. |
| Description: | xxiii, 228 p. : ill., map ; 29 cm. |
| Language: | English |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4403161 |
Table of Contents:
- Foreword
- Preface
- Chapter 1. General Concepts in Biodegradation and Biocatalysis
- Definition of Terms
- Further Resources in Biocatalysis and Biodegradation
- Chapter 2. A History of Concepts in Biodegradation and Microbial Catalysis
- The Beginnings of Biodegradation on Earth
- Early Human Observations of Biodegradation and Biocatalysis
- Early Scientific Studies on Biodegradation and the Spontaneous-Generation Debate
- Microbial Pure Cultures from Nature
- Early History of the Study of Diverse Metabolic Activities of Microbes
- Unity of Metabolism in Living Things
- Oxygen and Oxygenases
- History of Anaerobic Biocatalysis
- Molecular Genetics and Regulation
- Microbes in Organic Synthesis
- Summary
- Chapter 3. Identifying Novel Microbial Catalysis by Enrichment Culture and Screening
- Why Use Enrichment Culture?
- The General Method
- Selection of Conditions and Medium
- Screening for Specific Biocatalytic Reactions
- Summary
- Chapter 4. Microbial Diversity: Catabolism of Organic Compounds Is Broadly Distributed
- The Importance of Microbial (Bio)diversity
- Fungi in Biocatalysis and Biodegradation
- Distribution in the Prokaryotic World of Biodegradative and Novel Biocatalytic Capabilities
- Specialized Biodegradation by Microorganisms with Specialized Metabolisms
- Aerobic versus Anaerobic Microorganisms in Biodegradation
- Representative Microorganisms with Broad Catabolic Abilities
- Microbial Consortia in Biodegradation
- Global Biodegradation and the Supraorganism Concept
- Summary
- Chapter 5. Organic Functional Group Diversity: the Unity of Biochemistry Is Dwarfed by Its Diversity
- Microbial Global Cycling of the Elements
- Facts and Fallacies: Natural Products versus Synthetic Chemicals and Their Biodegradation
- An Organic Functional Group Classification
- Organic Functional Groups Found in Nature
- Ring Compounds Found in Nature
- Organic Functional Groups: What Is Known with Respect to Biodegradation and Microbial Biocatalysis?
- Summary
- Chapter 6. Physiological Processes: Enzymes, Emulsification, Uptake, and Chemotaxis
- General Physiological Responses to Environmental Chemicals
- Enzymes
- Enzyme Substrate Specificity
- Uptake: Getting Substrates to the Enzymes
- Emulsification: Overcoming Poor Availability of Substrate
- Organic-Solvent Resistance
- Chemotaxis: Getting to the Substrates
- Summary
- Chapter 7. Evolution of Catabolic Enzymes and Pathways
- History
- Major Protein Families in Microbial Biocatalysis
- Principles of Evolution Applied to Microbial Catabolism
- Gene Transfer in the Evolution of Catabolic Pathways
- Case Study: Enzyme Evolution in the Aminohydrolase Protein Superfamily
- Summary
- Chapter 8. Metabolic Logic and Pathway Maps
- Overview
- C[subscript 1] Metamap
- C[subscript 2] Metamap
- Cycloalkane Metamap
- BTEX Metamap: Aerobic Metabolism
- BTEX Metamap: Anaerobic Metabolism
- PAH Metamap
- Heterocyclic-Ring Metamap
- Triazine-Ring Metamap
- Organohalogen Metamap
- Organometallic Metamap
- Summary
- Chapter 9. Predicting Microbial Biocatalysis and Biodegradation
- Why Is It Necessary To Predict Biodegradation Pathways?
- Biodegradation Prediction Systems
- Defining the Trunk Pathways
- Defining the Organic Functional Groups Relevant to Microbial Catabolism
- The Basis for Predicting Microbial Biocatalysis and Biodegradation
- Beyond Two Functional Groups: the Need for Heuristics
- Summary
- Chapter 10. Microbial Biotechnology: Chemical Production and Bioremediation
- Historical and Conceptual Progress
- Recent Trends
- End Products of Fermentation: Pharmaceuticals
- Microbial Catalysis To Produce Chiral Products
- Chiral Synthesis of Dichloroprop
- Biocatalysis for Non-Medicinal, Non-Chiral Specialty Chemicals
- Biotechnological Waste Recycling
- Case Study of Bioremediation: Atrazine in Soil
- Summary
- Chapter 11. The Impact of Genomics on Microbial Catalysis
- Genome Sizes and Organization
- The Present Impact of Genomics
- Functional Genomics in the Context of Microbial Biocatalysis
- Inadvertent Deception in Modern Biochemistry Textbooks
- The Case for Reverse Functional Genomics and New Discovery in Biocatalysis
- Summary
- Chapter 12. The Extent of Microbial Catalysis and Biodegradation: Are Microbes Infallible?
- Microbial Enzyme Diversity
- Experiments Suggest that Novel Biocatalytic Reactions Are Ubiquitous
- Enzyme Plasticity and New Biocatalysts
- Summary
- Chapter 13. Big Questions and Future Prospects
- The Questions and Some Thoughts on Their Ultimate Answers
- Summary
- Appendixes
- A.. Books and Journals Relevant to Biodegradation and Biocatalysis
- B.. Useful Internet Resources in Biodegradation and Biocatalysis
- Index
