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00000cam a22000004a 4500 |
| 001 |
4403170 |
| 003 |
ICU |
| 005 |
20031020143400.0 |
| 008 |
000627s2000 enkaf b 001 0 eng |
| 010 |
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|a 00058032
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| 020 |
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|a 0198506333 (alk. paper)
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| 035 |
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|a 58032
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| 040 |
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|a DLC
|c DLC
|d DLC
|d OCoLC
|d OrLoB-B
|
| 042 |
|
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|a pcc
|
| 050 |
0 |
0 |
|a QP625.A29
|b F76 2000
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| 082 |
0 |
0 |
|a 572/.7921
|2 21
|
| 245 |
0 |
0 |
|a From DNA damage and stress signalling to cell death :
|b poly ADP-ribosylation reactions /
|c edited by Gilbert de Murcia and Sydney Shall.
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| 260 |
|
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|a Oxford ;
|a New York :
|b Oxford University Press,
|c 2000.
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| 300 |
|
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|a xxii, 238 p., [8] p. of colored plates :
|b ill. ;
|c 24 cm.
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| 336 |
|
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|a text
|b txt
|2 rdacontent
|0 http://id.loc.gov/vocabulary/contentTypes/txt
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| 337 |
|
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|a unmediated
|b n
|2 rdamedia
|0 http://id.loc.gov/vocabulary/mediaTypes/n
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| 338 |
|
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|a volume
|b nc
|2 rdacarrier
|0 http://id.loc.gov/vocabulary/carriers/nc
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| 504 |
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|a Includes bibliographical references and index.
|
| 505 |
0 |
0 |
|g 1.
|t ADP-ribose polymer metabolism --
|t Introduction to ADP-ribose transfer reactions --
|t Poly (ADP-ribose) --
|t Biosynthesis of poly (ADP-ribose) --
|t Poly (ADP-ribose) catabolism --
|g 2.
|t Poly (ADP-ribose) polymerase: structure and function --
|t The PARP gene and its tissue expression --
|t Subcellular location of PARP --
|t PARP is a modular enzyme, highly conserved during evolution --
|t The various DNA binding strategies of PARP --
|t The bipartite nuclear localization signal (NLS) contains a cleavage site for caspase-3 --
|t The automodification domain (module D) contains a BRCT motif: an interface for protein-protein contacts --
|t The catalytic domain and the connection with ADP-ribosylating toxins --
|t Plant PARPs and mammalian PARP homologues --
|g 3.
|t Biological significance of poly (ADP-ribosylation) reactions: molecular and genetic approaches --
|t PARP-deficient cell lines established by random mutagenesis --
|t PARP antisense strategies --
|t Expression of truncated and full-length PARPs in various systems --
|t Knockout mice: the survival role of PARP in mammals under genotoxic stress --
|t Searching for partners: the multiple facets of PARP function --
|t Future directions --
|g 4.
|t Poly (ADP-ribose) polymerase in cell death --
|t PARP as a survival factor for the cellular recovery from DNA damage --
|t Role of PARP in apoptosis --
|t PARP as a mediator of necrosis following excessive DNA damage --
|g 5.
|t Activation of poly (ADP-ribose) polymerase in the pathogenesis of ischaemia-reperfusion injury --
|t The poly (ADP-ribose) polymerase suicide hypothesis --
|t Tissue damage caused by nitric oxide-derived oxidant species --
|t Stroke and brain injury --
|t Myocardial ischaemia-reperfusion --
|t Splanchnic ischaemia-reperfusion --
|t Haemorrhagic shock --
|t Other pathophysiological conditions - conclusions --
|g 6.
|t New PARP inhibitors for radio- and chemotherapy of cancer --
|t Development of PARP inhibitors --
|t Biological activity of PARP inhibitors --
|t Conclusions and future directions --
|g 7.
|t Perspectives --
|t PARP and DNA damage signalling --
|t A function of poly (ADP-ribose) in controlling telomere length?
|
| 650 |
|
0 |
|a ADP-ribosylation.
|0 http://id.loc.gov/authorities/subjects/sh89006797
|
| 650 |
|
7 |
|a ADP-ribosylation.
|2 fast
|0 http://id.worldcat.org/fast/fst00793793
|
| 700 |
1 |
|
|a Murcia, Gilbert de
|0 http://id.loc.gov/authorities/names/n00013673
|1 http://viaf.org/viaf/61728231
|
| 700 |
1 |
|
|a Shall, S.
|q (Sydney),
|d 1932-
|0 http://id.loc.gov/authorities/names/n85236819
|1 http://viaf.org/viaf/109509253
|
| 901 |
|
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|a ToCBNA
|
| 903 |
|
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|a HeVa
|
| 903 |
|
|
|a Hathi
|
| 035 |
|
|
|a (OCoLC)44579017
|
| 929 |
|
|
|a cat
|
| 999 |
f |
f |
|i 837de20b-8742-526e-8300-cdcb326ef2f7
|s c51b6f61-d657-5df0-9bd7-64770c01a048
|
| 928 |
|
|
|t Library of Congress classification
|a QP625.A29 F76 2000
|l ASR
|c ASR-SciASR
|i 4501977
|
| 927 |
|
|
|t Library of Congress classification
|a QP625.A29 F76 2000
|l ASR
|c ASR-SciASR
|e CRERAR
|b 57280367
|i 6992547
|
